Oxysterol biosynthetic enzymes

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Regulation of the Acute Production of Steroids in Steroidogenic Cells*

1996 • 995 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Bile acid biosynthesis

1992 • 790 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

1991 • 479 citations

Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein

1996 • 473 citations

Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages

2000 • 386 citations

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

2000 • 355 citations

Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.

1991 • 353 citations

cDNA Cloning of Mouse and Human Cholesterol 25-Hydroxylases, Polytopic Membrane Proteins That Synthesize a Potent Oxysterol Regulator of Lipid Metabolism

1998 • 330 citations

Inhibition of Sterol Synthesis in Cultured Mouse Cells by Cholesterol Derivatives Oxygenated in the Side Chain

1974 • 330 citations

Disruption of Cholesterol 7α-Hydroxylase Gene in Mice

1996 • 265 citations

Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene

1998 • 263 citations

PLASMA LIPID TRANSFER PROTEINS, HIGH-DENSITY LIPOPROTEINS, AND REVERSE CHOLESTEROL TRANSPORT

1998 • 260 citations

Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids

1998 • 259 citations

Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice

2000 • 238 citations

Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid.

1980 • 221 citations

ON THE UTILIZATION OF ACETIC ACID FOR CHOLESTEROL FORMATION

1942 • 196 citations

The Biology of Cholesterol and Related Steroids

1981 • 196 citations

IMPACT OF VIRUS INFECTION ON HOST CELL PROTEIN SYNTHESIS

1987 • 188 citations

Nuclear receptor regulation of cholesterol and bile acid metabolism

1999 • 185 citations

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

1987 • 180 citations

Expression Cloning of an Oxysterol 7α-Hydroxylase Selective for 24-Hydroxycholesterol

2000 • 179 citations

Identification and Characterization of a Mouse Oxysterol 7α-Hydroxylase cDNA

1997 • 159 citations

Removal of cholesterol from extrahepatic sources by oxidative mechanisms

1999 • 133 citations

Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids.

1984 • 127 citations

Molecular cloning of cDNA for vitamin D₃ 25‐hydroxylase from rat liver mitochondria

1990 • 125 citations

24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis.

1985 • 117 citations

Activities of Recombinant Human Cytochrome P450c27 (CYP27) Which Produce Intermediates of Alternative Bile Acid Biosynthetic Pathways

1998 • 114 citations

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin

1999 • 110 citations

Characterization of Yeast Methyl Sterol Oxidase (ERG25) and Identification of a Human Homologue

1996 • 108 citations

Identification of the Lipophilic Factor Produced by Macrophages That Stimulates Steroidogenesis*

2000 • 97 citations

24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver

1993 • 79 citations

Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans

1999 • 71 citations

THE CONSTITUTION OF CEREBROSTEROL, A HYDROXYCHOLESTEROL ISOLATED FROM HORSE BRAIN

1953 • 63 citations

Sterol metabolism XXVIII. Biosynthesis and accumulation of cholest-5-ene-3β, 24-diol (cerebrosterol) in developing rat brain

1974 • 45 citations

Cytochrome P450 in the brain: 2B or not 2B

1998 • 27 citations

Oxidation of 5β-cholestane-3α,7α,12α-triol into 3α,7α,12α-trihydroxy-5β-cholestanoic acid by cytochrome P-45026 from rabbit liver mitochondria

1990 • 24 citations

Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway.

1996 • 21 citations