A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1996 • 444 citations

Spontaneous transformation and immortalization of human endothelial cells

1990 • 428 citations

Statistics of RNA secondary structures

1993 • 304 citations

Selecting effective antisense reagents on combinatorial oligonucleotide arrays

1997 • 267 citations

cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.

1989 • 251 citations

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

1994 • 250 citations

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

1992 • 223 citations

Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries

1998 • 188 citations

An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice.

1997 • 185 citations

Sequence Specific Thermodynamic and Structural Properties for DNA.cntdot.RNA Duplexes

1994 • 164 citations

Combinatorial Screening and Rational Optimization for Hybridization to Folded Hepatitis C Virus RNA of Oligonucleotides with Biological Antisense Activity

1997 • 131 citations

Quantitative Hybridization Kinetics of DNA Probes to RNA in Solution Followed by Diffusional Fluorescence Correlation Analysis

1996 • 126 citations

Probing accessible sites for ribozymes on human acetylcholinesterase RNA.

1997 • 96 citations

Tetranucleotide GGGA Motif in Primary RNA Transcripts

1998 • 95 citations

β2 Integrin/ICAM Expression in Crohn's Disease

1998 • 84 citations

Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts

1998 • 83 citations

In vitro selection of fast-hybridizing and effective antisense RNAs directed against the human immunodeficiency virus type 1

1993 • 80 citations

Theoretical design of antisense RNA structures substantially improves annealing kinetics and efficacy in human cells

1998 • 79 citations

Computer-Aided Search for Effective Antisense RNA Target Sequences of the Human Immunodeficiency Virus Type 1

1993 • 68 citations

Selective cleavage ofbcr-ablchimeric RNAs by a ribozyme targeted to non-contiguous sequences

1994 • 49 citations

X-HUSAR, an X-based graphical interface for the analysis of genomic sequences

1995 • 48 citations

Implications of RNA Structure on the Annealing of a Potent Antisense RNA Directed against the Human Immunodeficiency Virus Type 1

1997 • 28 citations

Efficient Improvement of Hammerhead Ribozyme Mediated Cleavage of Long Substrates by Oligonucleotide Facilitators

1996 • 27 citations

Computational Approaches to the Identification of Ribozyme Target Sites

2003 • 17 citations

Antisense ICAM-1 oligonucleotides block allograft rejection in rats

1997 • 16 citations