The immunobiology of primary sclerosing cholangitis

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

1990 • 1,214 citations

Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress

1994 • 1,178 citations

HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

2004 • 1,175 citations

Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS

2002 • 1,170 citations

Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis.

1996 • 804 citations

PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis

2004 • 738 citations

Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis

1989 • 643 citations

Incidence and Prevalence of Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Hepatitis in a Norwegian Population

1998 • 512 citations

Natural history and prognostic variables in primary sclerosing cholangitis

1991 • 473 citations

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

2004 • 445 citations

Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a united states community

2003 • 433 citations

Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis

2004 • 317 citations

Relationship of Inflammatory Bowel Disease and Primary Sclerosing Cholangitis

1991 • 289 citations

Cutting Edge: Heterozygote Advantage in Autoimmune Disease: Hierarchy of Protection/Susceptibility Conferred by HLA and Killer Ig-Like Receptor Combinations in Psoriatic Arthritis

2004 • 281 citations

KIR and disease: a model system or system of models?

2006 • 279 citations

Association of primary sclerosing cholangitis with HLA-B8.

1983 • 270 citations

Madcam–1 Expressed in Chronic Inflammatory Liver Disease Supports Mucosal Lymphocyte Adhesion to Hepatic Endothelium (Madcam–1 in Chronic Inflammatory Liver Disease)

2001 • 269 citations

Prevalence of autoimmune liver disease in Alaska natives

2002 • 247 citations

Identification of Helicobacter pylori and Other Helicobacter Species by PCR, Hybridization, and Partial DNA Sequencing in Human Liver Samples from Patients with Primary Sclerosing Cholangitis or Primary Biliary Cirrhosis

2000 • 244 citations

Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease

2002 • 239 citations

Induction and function of vascular adhesion protein-1 at sites of inflammation.

1993 • 235 citations

Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells

2002 • 234 citations

Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth

1990 • 211 citations

HLA Antigens and Immunoregulatory T Cells in Ulcerative Colitis Associated with Hepatobiliary Disease

1982 • 207 citations

Vascular Adhesion Protein-1 and ICAM-1 Support the Adhesion of Tumor-Infiltrating Lymphocytes to Tumor Endothelium in Human Hepatocellular Carcinoma

1998 • 181 citations

BSEP andMDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis

2004 • 180 citations

“Atypical p-ANCA” in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines

2000 • 177 citations

HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

1999 • 173 citations

Association of Primary Sclerosing Cholangitis with HLA-DRw52a

1990 • 171 citations

Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline

1991 • 171 citations

Epidemiology of primary sclerosing cholangitis in Spain

1994 • 171 citations

Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

2006 • 170 citations

Circulating Form of Human Vascular Adhesion Protein-1 (VAP-1): Increased Serum Levels in Inflammatory Liver Diseases

1998 • 169 citations

Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease

2002 • 161 citations

Rules of Recruitment for Th1 and Th2 Lymphocytes in Inflamed Liver: A Role for Alpha-4 Integrin and Vascular Adhesion Protein-1

2005 • 157 citations

Etiopathogenesis of Primary Sclerosing Cholangitis

2006 • 154 citations

Amino Acid Substitutions At Position 38 of the Drβ Polypeptide Confer Susceptibility to and Protection From Primary Sclerosing Cholangitis

1992 • 140 citations

Antibody Blockade of CCL25/CCR9 Ameliorates Early but not Late Chronic Murine Ileitis

2006 • 136 citations

Bile duct bacterial isolates in primary sclerosing cholangitis: a study of explanted livers

1998 • 134 citations

Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

2003 • 130 citations

Immunohistochemical Characterization of Hepatic Lymphocytes in Primary Biliary Cirrhosis in Comparison With Primary Sclerosing Cholangitis and Autoimmune Chronic Active Hepatitis

1993 • 128 citations

Biliary tract disease in rats with experimental small bowel bacterial overgrowth

1991 • 124 citations

Protective Effect of the HLA‐Bw4I80 Epitope and the Killer Cell Immunoglobulin‐Like Receptor 3DS1 Gene against the Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection

2005 • 123 citations

High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6

2002 • 120 citations

Risk factors in primary sclerosing cholangitis

1994 • 120 citations

Primary sclerosing cholangitis: clinical presentation, natural history and prognostic variables: an Italian multicentre study. The Italian PSC Study Group.

1996 • 120 citations

Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium

1996 • 119 citations

Vascular Adhesion Protein 1 (VAP-1) Mediates Lymphocyte Subtype-specific, Selectin-independent Recognition of Vascular Endothelium in Human Lymph Nodes

1997 • 116 citations

Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis

2001 • 115 citations

Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders

1996 • 113 citations

Analysis of 388 cases of primary sclerosing cholangitis in JapanPresence of a subgroup without pancreatic involvement in older patients

2004 • 112 citations

Autoimmune liver disease: overlap and outliers

2007 • 111 citations

The role of dominant stenoses in bacterial infections of bile ducts in primary sclerosing cholangitis

2005 • 108 citations

Immunologic Analysis of Mononuclear Cells in Liver Tissues and Blood of Patients With Primary Sclerosing Cholangitis

1985 • 107 citations

Mapping MHC-encoded susceptibility and resistance in primary sclerosing cholangitis: The role of MICA polymorphism

2001 • 105 citations

Expression of the mucosal vascular addressin, MAdCAM‐1, in inflammatory liver disease

1999 • 95 citations

Helicobacter species and hepatobiliary diseases

2002 • 94 citations

Elevation of ?? T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases

1996 • 93 citations

Primary sclerosing cholangitis is associated to an extended B8-DR3 haplotype including particular MICA and MICB alleles

2001 • 90 citations

Clinical profile of primary sclerosing cholangitis in Singapore

2002 • 90 citations

Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth.

1992 • 89 citations

Enterohepatic circulation of bacterial chemotactic peptide in rats with experimental colitis

1988 • 82 citations

Identification and characterization of autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis

1998 • 82 citations

Immunogenicity of biliary epithelium: Investigation of antigen presentation to CD4+ T cells

1996 • 80 citations

Progressive development of a Th1-type hepatic cytokine profile in rats with experimental cholangitis

2000 • 77 citations

Epidemiology of primary sclerosing cholangitis

2001 • 77 citations

Distribution of HLA-DR, HLA-DP, HLA-DQ Antigens in Liver Tissue from Patients with Primary Sclerosing Cholangitis

1990 • 75 citations

Induction of colitis in cftr^−/− mice results in bile duct injury

2004 • 75 citations

Anti-neutrophil antibodies in primary sclerosing cholangitis

2001 • 74 citations

CCR5-Δ32 mutation is strongly associated with primary sclerosing cholangitis

2004 • 69 citations

Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease

2004 • 68 citations

Susceptibility to primary sclerosing cholangitis is associated with polymorphisms of intercellular adhesion molecule-1

2003 • 67 citations

Intestinal permeability and bacterial growth of the small bowel in patients with primary sclerosing cholangitis

2005 • 64 citations

Hepatocyte tight-junctional permeability is increased in rat experimental colitis

1997 • 61 citations

Cytokines in Primary Biliary Cirrhosis

1997 • 61 citations

Primary sclerosing cholangitis

2003 • 60 citations

Antineutrophil cytoplasmic antibodies in chronic liver diseases: prevalence, titre, specificity and IgG subclass

1996 • 60 citations

Elevation of activated γδ T cell receptor bearing T lymphocytes in patients with autoimmune chronic liver disease

1992 • 59 citations

Small duct cholangitis induced byn-formyll-methioninel-leucinel-tyrosine in rats

1994 • 58 citations

Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study

1998 • 57 citations

Increased prevalence of seropositivity for non-gastric Helicobacter species in patients with autoimmune liver disease

2003 • 57 citations

Anti‐neutrophil cytoplasmic antibody: A prognostic indicator in primary sclerosing cholangitis

1994 • 56 citations

T-lymphocyte subsets in liver tissues of patients with primary biliary cirrhosis (PBC), patients with primary sclerosing cholangitis (PSC), and normal controls

1984 • 55 citations

Role of IL-10 in Hepatocyte Tight Junction Alteration in Mouse Model of Experimental Colitis

2002 • 54 citations

Primary sclerosing cholangitis: An experience from India

1996 • 53 citations

Peripheral blood and portal tract lymphocyte populations in primary sclerosing cholangitis

1989 • 52 citations

Biliary secretion of bile acids and lipids in primary sclerosing cholangitis.Influence of cholestasis and effect of ursodeoxycholic acid treatment

1995 • 51 citations

Animal models for primary sclerosing cholangitis

2001 • 51 citations

Accumulation of macrophages in primary sclerosing cholangitis

2001 • 50 citations

Bile duct bacterial isolates in primary sclerosing cholangitis and certain other forms of cholestasis--a study of bile cultures from ERCP.

2001 • 49 citations

Genetic Polymorphisms Associated With Inflammatory Bowel Disease Do Not Confer Risk for Primary Sclerosing Cholangitis

2006 • 49 citations

The endotoxin-binding bactericidal/permeability-increasing protein (BPI): a target antigen of autoantibodies

2001 • 46 citations

Preferential Vβ3 usage by hepatic T lymphocytes in patients with primary sclerosing cholangitis

1997 • 46 citations

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-γ upon mitogen stimulation

1992 • 44 citations

A survey of infectious agents as risk factors for primary sclerosing cholangitis: are Chlamydia species involved?

2002 • 42 citations

Aetiopathogenesis of primary sclerosing cholangitis

2001 • 39 citations

Primary Sclerosing Cholangitis

2015 • 39 citations

HLA antigens in ulcerative colitis and primary sclerosing cholangitis

1995 • 38 citations

Analysis of human common bile duct-associated T cells: evidence for oligoclonality, T cell clonal persistence, and epithelial cell recognition.

1997 • 37 citations

The role ofHelicobacterspp. in the pathogenesis of primary biliary cirrhosis and primary sclerosing cholangitis

2004 • 36 citations

IgA class antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and autoimmune hepatitis

2003 • 31 citations

Expression of CD44 on bile ducts in primary sclerosing cholangitis and primary biliary cirrhosis

1999 • 31 citations

In situ heterogeneity of peroxisomal oxidase activities: An update

1996 • 30 citations

Primary sclerosing cholangitis: Clinical and immunopathological review of 21 cases

1990 • 30 citations

Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population

2003 • 29 citations

CC-Type chemokine receptor 5-Δ32 mutation protects against primary sclerosing cholangitis

2006 • 28 citations

Therapeutic Effect of Repeated Natural Killer T Cell Stimulation in Mouse Cholangitis Complicated by Colitis

2005 • 27 citations

Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis

2006 • 24 citations

The 32‐base pair deletion of the chemokine receptor 5 gene (CCR5‐Δ32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients

2006 • 22 citations

Immune response in mouse experimental cholangitis associated with colitis induced by dextran sulfate sodium

2004 • 21 citations

Radio‐immunoassay for formyl methionyl leucyl phenylalanine. I. Development and application to assessment of chemotactic peptide production by enteric bacteria

1990 • 20 citations

Gene Expression by PBMC in Primary Sclerosing Cholangitis: Evidence for Dysregulation of Immune Mediated Genes

2006 • 20 citations

Inhibition of T cell activation by normal human biliary epithelial cells

1999 • 19 citations

Macrophages are essential for lymphocyte infiltration in formyl peptide‐induced cholangitis in rat liver

1999 • 18 citations

Hepatic leukocyte recruitment in a model of acute colitis

2002 • 13 citations

Cytokine production from colonic T cells in patients with ulcerative colitis with and without primary sclerosing cholangitis

1998 • 10 citations

Hepatobiliary excretion of bacterial formyl-methionyl peptides in rat

1992 • 10 citations

CCR5Δ32 polymorphism in inflammatory bowel disease: Further association with ulcerative colitis and with primary sclerosing cholangitis

2000 • 9 citations

Phenotypic and functional characteristics of colonic lymphocytes isolated from patients with primary sclerosing cholangitis and inflammatory bowel disease.

1995 • 8 citations