New Perspectives On The Role Of Aldosterone Excess In Cardiovascular Disease

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

2000 • 2,991 citations

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.

1990 • 1,151 citations

A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

1992 • 1,126 citations

Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke

1972 • 1,098 citations

Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome.

1955 • 952 citations

Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

2000 • 928 citations

HIGH INCIDENCE OF PRIMARY ALDOSTERONISM IN 199 PATIENTS REFERRED WITH HYPERTENSION

1994 • 498 citations

Myocardial Production of Aldosterone and Corticosterone in the Rat

1998 • 447 citations

Mineralocorticoids, hypertension, and cardiac fibrosis.

1994 • 440 citations

Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology¹

2000 • 418 citations

Activation of Cardiac Aldosterone Production in Rat Myocardial Infarction

1999 • 375 citations

Prevalence of Primary Aldosteronism among Asian Hypertensive Patients in Singapore1

2000 • 343 citations

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

1997 • 342 citations

Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells.

1994 • 314 citations

Changes in Left Ventricular Anatomy and Function in Hypertension and Primary Aldosteronism

1996 • 304 citations

Suppression of Plasma Renin Activity in Primary Aldosteronism

1964 • 301 citations

Prerequisite for Cardiac Aldosterone Action

1995 • 286 citations

Remodeling of the Left Ventricle in Primary Aldosteronism Due to Conn’s Adenoma

1997 • 263 citations

Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology

2000 • 259 citations

Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis

1995 • 254 citations

Aldosterone Excretion Rate and Blood Pressure in Essential Hypertension Are Related to Polymorphic Differences in the Aldosterone Synthase Gene CYP11B2

1999 • 249 citations

Determinants of cardiac fibrosis in experimental hypermineralocorticoid states

1995 • 234 citations

Angiotensin AT ₁ Receptor Subtype as a Cardiac Target of Aldosterone

1999 • 232 citations

Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion

1997 • 228 citations

Associations Between Human Aldosterone Synthase (CYP11B2) Gene Polymorphisms and Left Ventricular Size, Mass, and Function

1998 • 217 citations

Aldosterone Biosynthesis in the Rat Brain¹

1997 • 212 citations

A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)

2000 • 208 citations

Konstitution des Aldosterons, des neuen Mineralocorticoids

1954 • 202 citations

EVIDENCE THAT PRIMARY ALDOSTERONISM MAY NOT BE UNCOMMON: 12% INCIDENCE AMONG ANTIHYPERTENSIVE DRUG TRIAL VOLUNTEERS

1993 • 190 citations

Prevention of Aortic Fibrosis by Spironolactone in Spontaneously Hypertensive Rats

1997 • 187 citations

Biological Determinants of Aldosterone-Induced Cardiac Fibrosis in Rats

1995 • 173 citations

Production of Aldosterone in Isolated Rat Blood Vessels

1995 • 173 citations

Spironolactone in congestive heart failure refractory to high-dose loop diuretic and low-dose angiotensin-converting enzyme inhibitor

1993 • 169 citations

Prevalence of Primary Aldosteronism among Asian Hypertensive Patients in Singapore

2000 • 169 citations

PLASMA RENIN ACTIVITY IN PRIMARY ALDOSTERONISM. IMPORTANCE IN DIFFERENTIAL DIAGNOSIS AND IN RESEARCH OF ESSENTIAL HYPERTENSION.

1964 • 168 citations

A New Genetic Test for Familial Hyperaldosteronism Type I Aids in the Detection of Curable Hypertension

1995 • 154 citations

Association Between Increased Plasma Levels of Aldosterone and Decreased Systemic Arterial Compliance in Subjects With Essential Hypertension

1997 • 152 citations

3 Disorders of the adrenal cortex

1992 • 149 citations

CLINICAL AND PATHOLOGICAL DIVERSITY OF PRIMARY ALDOSTERONISM, INCLUDING A NEW FAMILIAL VARIETY

1991 • 143 citations

Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension

1993 • 137 citations

Effect of Spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy

2000 • 128 citations

Myocardial fibrosis and pathologic hypertrophy in the rat with renovascular hypertension

1990 • 126 citations

Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass.

1997 • 125 citations

HIGH AFFINITY ALDOSTERONE BINDING SITES (TYPE I RECEPTORS) IN RAT HEART

1987 • 121 citations

Aldosterone reduces baroreceptor discharge in the dog.

1992 • 120 citations

Plasma Renin Activity in Primary Aldosteronism

1964 • 112 citations

Aldosterone escape during ACE inhibitor therapy in chronic heart failure

1995 • 109 citations

Aldosterone and cardiac fibrosis: in vitro studies

1994 • 108 citations

The aldosterone/renin ratio as a screening test for primary aldosteronism.

2000 • 96 citations

Hormonal regulation of cardiac fibroblast function

1995 • 96 citations

Primary Aldosteronism: Update on Diagnosis and Treatment

1997 • 95 citations

Short-term and Sustained Renal Effects of Angiotensin II Receptor Blockade in Healthy Subjects

1995 • 95 citations

Aldosterone blunts the baroreflex response in man

1998 • 92 citations

Aldosterone Biosynthesis in the Rat Brain

1997 • 88 citations

Myocardial Fibrosis in the Rat With Mineralocorticoid Excess Prevention of Scarring by Amiloride

1993 • 80 citations

Primary aldosteronism

2000 • 74 citations

Bartter syndrome: unraveling the pathophysiologic enigma

1998 • 72 citations

Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle

1982 • 60 citations

Impact of aldosterone on left ventricular structure and function in young normotensive and mildly hypertensive subjects

2000 • 58 citations

Severity of Hypertension in Familial Hyperaldosteronism Type I: Relationship to Gender and Degree of Biochemical Disturbance¹

2000 • 55 citations

Joint Effects of an Aldosterone Synthase (CYP11B2) Gene Polymorphism and Classic Risk Factors on Risk of Myocardial Infarction

1999 • 49 citations

The role of calcium antagonists in the treatment of chronic heart failure

1993 • 47 citations

Biochemical Evidence of Aldosterone Overproduction and Abnormal Regulation in Normotensive Individuals with Familial Hyperaldosteronism Type I¹

1999 • 43 citations

Severity of Hypertension in Familial Hyperaldosteronism Type I: Relationship to Gender and Degree of Biochemical Disturbance

2000 • 37 citations

Biochemical Evidence of Aldosterone Overproduction and Abnormal Regulation in Normotensive Individuals with Familial Hyperaldosteronism Type I

1999 • 36 citations

Mineralocorticoid modulation of central control of blood pressure

1995 • 35 citations

Familial Forms Broaden the Horizons for Primary Aldosteronism

1998 • 35 citations

Corticosteroid Production by Fetal Rat Hippocampal Neurons

2000 • 34 citations

Captopril and spironolactone therapy for refractory congestive heart failure

1993 • 31 citations

Disorders of the Adrenal Cortex I

1979 • 28 citations

Myocardial scintigraphic characteristics in patients with primary aldosteronism.

1994 • 26 citations

Renovascular hypertension: a paradigm for all hypertension.

1986 • 22 citations

Evidence of exercise-induced myocardial ischemia in patients with primary aldosteronism: the Cross-sectional Primary Aldosteronism and Heart Italian Multicenter Study.

1999 • 15 citations

Genetic Studies in Familial Aldosteronism Not Suppressible by Dexamethasone

2000 • 15 citations

Opposite associations of circulating aldosterone and atrial natriuretic peptide with left ventricular diastolic function in essential hypertension

1998 • 15 citations

Mineralocorticoid receptor blockade in chronic heart failure.

1995 • 10 citations