Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology¹

The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure

1997 • 5,689 citations

Williams Textbook of Endocrinology

2016 • 3,772 citations

Hypertension : pathophysiology, diagnosis, and management

1995 • 1,895 citations

A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

1992 • 1,126 citations

Principles and Practice of Endocrinology and Metabolism.

1991 • 801 citations

Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone.

1966 • 458 citations

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

1989 • 440 citations

A screening test to identify aldosterone-producing adenoma by measuring plasma renin activity. Results in hypertensive patients

1981 • 356 citations

The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex

1991 • 348 citations

Computed Body Tomography with MRI Correlation.

1991 • 335 citations

Diagnosis and Treatment of Primary Hyperaldosteronism

1994 • 298 citations

A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.

1991 • 264 citations

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

1992 • 263 citations

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

1992 • 236 citations

Normokalemic Primary Aldosteronism

1965 • 236 citations

Diagnosis under Random Conditions of All Disorders of the Renin-Angiotensin-Aldosterone Axis, Including Primary Hyperaldosteronism

1991 • 200 citations

EVIDENCE THAT PRIMARY ALDOSTERONISM MAY NOT BE UNCOMMON: 12% INCIDENCE AMONG ANTIHYPERTENSIVE DRUG TRIAL VOLUNTEERS

1993 • 190 citations

Incidence of hypertension in the Framingham Study.

1988 • 165 citations

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

1990 • 155 citations

A New Genetic Test for Familial Hyperaldosteronism Type I Aids in the Detection of Curable Hypertension

1995 • 154 citations

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

1991 • 142 citations

Missense mutation serine106—-proline causes 17 alpha-hydroxylase deficiency

1991 • 137 citations

ELEVATED URINARY EXCRETION OF 18-OXOCORTISOL IN GLUCOCORTICOID-SUPPRESSIBLE ALDOSTERONISM

1984 • 119 citations

Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism.

1982 • 118 citations

Diagnosis of Glucocorticoid-Remediable Aldosteronism in Primary Aldosteronism: Aldosterone Response to Dexamethasone and Long Polymerase Chain Reaction for Chimeric Gene

1998 • 117 citations

Frequency of surgical treatment for hypertension in adults at the Mayo Clinic from 1973 through 1975.

1977 • 114 citations

A naturally immunogenic virion-associated protein specific for HIV-2 and SIV

1988 • 113 citations

Biosynthesis of 18-oxocortisol by aldosterone-producing adrenal tissue.

1983 • 96 citations

Defective Fasciculata Zone Function as the Mechanism of Glucocorticoid-Remediable Aldosteronism*

1990 • 88 citations

Evaluation of the Dexamethasone Suppression Test for the Diagnosis of Glucocorticoid-Remediable Aldosteronism1

1997 • 85 citations

Dexamethasone-Suppressible Hyperaldosteronism

1973 • 83 citations

Glucocorticoid-remediable aldosteronism (GRA): Diagnosis, variability of phenotype and regulation of potassium homeostasis

1995 • 77 citations

Genetic variation in P450c11AS in Chilean patients with low renin hypertension.

1996 • 74 citations

Plasma aldosterone-plasma renin activity ratio A simple test to identify patients with primary aldosteronism

1986 • 60 citations

Primary Aldosteronism: Issues in Diagnosis and Management

1994 • 59 citations

Primary hyperaldosteronism: A missed diagnosis in ‘essential hypertensives’?

1996 • 58 citations

Molecular Biology of Mineralocorticoid Metabolism

1996 • 58 citations

The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism.

1993 • 55 citations

Primary aldosteronism. Part I. Diagnosis of primary hyperaldosteronism.

1996 • 49 citations

Glucocorticoid-Suppressible Aldosteronism: A Disorder of the Adrenal Transitional Zone*

1988 • 47 citations

Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?

1995 • 30 citations

Biotin-hydrazide derivatives for the development of steroid enzyme-linked immunoassays

1992 • 29 citations

Inappropriate Elevation of the Aldosterone/Plasma Renin Activity Ratio in Hypertensive Patients with Increases of 11-Deoxycorticosterone and 18-Hydroxy-ll-Deoxycorticosterone: A Subtype of Essential Hypertension?

1991 • 22 citations

Value of renin measurement, saralasin test, and acebutolol treatment in hypertension

1979 • 18 citations

Simultaneous measurement of plasma 18-oxocortisol and 18-hydroxycortisol levels in normal man

1994 • 13 citations