Measuring Oxidative mtDNA Damage and Repair Using Quantitative PCR

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

Characterization of PicoGreen Reagent and Development of a Fluorescence-Based Solution Assay for Double-Stranded DNA Quantitation

1997 • 752 citations

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

1998 • 694 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Mitochondrial DNA repair pathways

1999 • 241 citations

Mitochondrial DNA mutations and neuromuscular disease

1989 • 216 citations

8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage

1999 • 209 citations

Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

1993 • 175 citations

Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay

1992 • 166 citations

Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin.

1991 • 153 citations

Repair of DNA damage in mitochondria

1999 • 150 citations

MIPS: a database for protein sequences and complete genomes

1998 • 135 citations

Repair of alkylation and oxidative damage in mitochondrial DNA

1999 • 113 citations

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

1998 • 98 citations

Bcl-2 Facilitates Recovery from DNA Damage after Oxidative Stress

1999 • 96 citations

DNA damage in brain mitochondria caused by aging and MPTP treatment

2000 • 78 citations

An established avian fibroblast cell line without mitochondrial DNA

1986 • 70 citations

Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase μ

1999 • 56 citations

Ubisemiquinone radicals from the cytochrome b−c1 complex of the mitochondrial electron transport chain—Demonstration of QP-S radical formation

1981 • 54 citations

PCR-Based Assays for the Detection and Quantitation of DNA Damage and Repair

1996 • 40 citations

High Resolution Mapping of UV-induced Photoproducts in the Escherichia coli lacI Gene

1994 • 33 citations