Repression of Clostridium difficile toxin gene expression by CodY

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

1995 • 4,806 citations

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

2005 • 1,422 citations

Clostridium difficileToxins: Mechanism of Action and Role in Disease

2005 • 1,103 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

2006 • 866 citations

The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins

1995 • 478 citations

Clostridium difficile Infection

1998 • 421 citations

Effects of Clostridium difficile toxins given intragastrically to animals

1985 • 398 citations

An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins.

1988 • 374 citations

CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria

2005 • 344 citations

Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels

2001 • 335 citations

Definition of the single integration site of the pathogenicity locus in Clostridium difficile

1996 • 315 citations

Regulated transcription of Clostridium difficile toxin genes

1998 • 288 citations

Additional Targets of theBacillus subtilisGlobal Regulator CodY Identified by Chromatin Immunoprecipitation and Genome-Wide Transcript Analysis

2003 • 288 citations

Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins

1996 • 250 citations

Detection and identification of Listeria monocytogenes in cooked sausage products and in milk by in vitro amplification of haemolysin gene fragments

1991 • 250 citations

Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

2001 • 245 citations

Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

2007 • 224 citations

Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched‐chain amino acids

2004 • 213 citations

Shuttle vectors containing a multiple cloning site and a lacZα gene for conjugal transfer of DNA from Escherichia coli to Gram-positive bacteria

1991 • 202 citations

tcdC Genotypes Associated with Severe TcdC Truncation in an Epidemic Clone and Other Strains of Clostridium difficile

2006 • 198 citations

Transcription Analysis of the Genes tcdA‐E of the Pathogenicity Locus of Clostridium Difficile

1997 • 191 citations

The Lactococcus lactis CodY Regulon

2005 • 182 citations

A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon

1995 • 178 citations

Construction and analysis of chromosomal Clostridium difficile mutants

2006 • 164 citations

Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence

2007 • 152 citations

Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile

2001 • 143 citations

Transferable tetracycline resistance in Clostridium difficile

1981 • 137 citations

Suppression of toxin production in Clostridium difficile VPI 10463 by amino acids

1999 • 137 citations

Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression

2002 • 136 citations

Overall control of nitrogen metabolism in Lactococcus lactis by CodY, and possible models for CodY regulation in Firmicutes

2005 • 135 citations

Regulation of Glutamine and Glutamate Metabolism by GlnR and GlnA in Streptococcus pneumoniae

2006 • 133 citations

The toxigenic element of Clostridium difficile strain VPI 10463

1995 • 132 citations

Toxins, Butyric Acid, and Other Short-Chain Fatty Acids Are Coordinately Expressed and Down-Regulated by Cysteine in Clostridium difficile

2000 • 127 citations

Linking the nutritional status of Streptococcus pyogenes to alteration of transcriptional gene expression: The action of CodY and RelA

2006 • 102 citations

Transferable Resistance to Clindamycin, Erythromycin, and Tetracycline in Clostridium difficile

1983 • 102 citations

The Structure of CodY, a GTP- and Isoleucine-responsive Regulator of Stationary Phase and Virulence in Gram-positive Bacteria

2006 • 92 citations

Expression of Clostridium difficile Toxins A and B and Their Sigma Factor TcdD Is Controlled by Temperature

2003 • 86 citations

Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication

2006 • 78 citations

Direct and indirect roles of CcpA in regulation of Bacillus subtilis Krebs cycle genes

2002 • 77 citations

Effect of environmental stress on Clostridium difficile toxin levels during continuous cultivation

1979 • 75 citations

Monoclonal and specific polyclonal antibodies for immunoassay of Clostridium difficile toxin A

1985 • 66 citations

Conjugative Transfer of RP4-oriTShuttle Vectors fromEscherichia colitoClostridium perfringens

1998 • 61 citations

Complex Regulation of the Bacillus subtilis Aconitase Gene

2003 • 58 citations

Transcriptional analysis of the toxigenic element ofClostridium difficile

1997 • 56 citations

A Region ofBacillus subtilisCodY Protein Required for Interaction with DNA

2005 • 48 citations

Toxin production by Clostridium difficile in a defined medium with limited amino acids

1994 • 45 citations

CodY-Regulated Aminotransferases AraT and BcaT Play a Major Role in the Growth of Lactococcus lactis in Milk by Regulating the Intracellular Pool of Amino Acids

2003 • 44 citations

Effect of Arginine on Toxin Production by Clostridium difficile in Defined Medium

1997 • 43 citations

Effect of Isoleucine on Toxin Production by Clostridium difficile in a Defined Medium

1998 • 35 citations

Effect of Clindamycin on Cytotoxin Production by Clostridium difficile

1982 • 32 citations

Inhibition of enhanced toxin production by Clostridium difficile in biotin-limited conditions

1998 • 23 citations