Regulation of Nicotinic Acetylcholine Receptor Assembly

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

2001 • 1,088 citations

A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels

1999 • 1,038 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation

2002 • 542 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48

2002 • 530 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

2002 • 470 citations

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

2001 • 463 citations

Specification of Subunit Assembly by the Hydrophilic Amino-Terminal Domain of the Shaker Potassium Channel

1992 • 449 citations

Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone

2001 • 441 citations

Assembly of influenza hemagglutinin trimers and its role in intracellular transport.

1986 • 413 citations

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

2001 • 408 citations

ER quality control: towards an understanding at the molecular level

2001 • 392 citations

Proteasomes: destruction as a programme

1996 • 373 citations

βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis

1996 • 372 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

The T Cell Antigen Receptor: Insights into Organelle Biology

1990 • 361 citations

ER protein quality control and proteasome-mediated protein degradation

1999 • 348 citations

E3 ubiquitin ligase that recognizes sugar chains

2002 • 344 citations

Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum

2000 • 331 citations

Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

1999 • 317 citations

A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System

2002 • 301 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1995 • 263 citations

Deletion analysis of K+ channel assembly

1993 • 239 citations

Rapsyn Mutations in Humans Cause Endplate Acetylcholine-Receptor Deficiency and Myasthenic Syndrome

2002 • 237 citations

Cytosolic Degradation of T-cell Receptor α Chains by the Proteasome

1997 • 220 citations

Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes

1998 • 218 citations

Regulation of Connexin Degradation as a Mechanism to Increase Gap Junction Assembly and Function

2000 • 217 citations

Assembly in vivo of mouse muscle acetylcholine receptor: Identification of an α subunit species that may be an assembly intermediate

1983 • 204 citations

Endoplasmic Reticulum Degradation of a Mutated ATP-binding Cassette Transporter Pdr5 Proceeds in a Concerted Action of Sec61 and the Proteasome

1998 • 188 citations

The nicotinic receptor ligand binding domain

2002 • 159 citations

Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

2000 • 147 citations

Acetylcholine receptor assembly: Subunit folding and oligomerization occur sequentially

1993 • 146 citations

Rapsyn Escorts the Nicotinic Acetylcholine Receptor Along the Exocytic Pathway via Association with Lipid Rafts

2002 • 140 citations

Host Cell‐Specific Folding and Assembly of the Neuronal Nicotinic Acetylcholine Receptor α7 Subunit

1997 • 134 citations

The Proteasome

2001 • 132 citations

Molecular Cloning of the Human Glucose‐Regulated Protein ERp57/GRP58, a Thiol‐Dependent Reductase

1995 • 127 citations

Endoplasmic Reticulum (ER)-associated Degradation of T Cell Receptor Subunits

2001 • 126 citations

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα

1999 • 122 citations

ENaC Degradation in A6 Cells by the Ubiquitin-Proteosome Proteolytic Pathway

2001 • 119 citations

Formation of the alpha-bungarotoxin binding site and assembly of the nicotinic acetylcholine receptor subunits occur in the endoplasmic reticulum.

1987 • 119 citations

Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells.

1991 • 116 citations

Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits.

1988 • 114 citations

Evidence That Endoplasmic Reticulum (ER)-associated Degradation of Cystic Fibrosis Transmembrane Conductance Regulator Is Linked to Retrograde Translocation from the ER Membrane

1999 • 112 citations

The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing

1994 • 108 citations

BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor.

1991 • 108 citations

HRDGene Dependence of Endoplasmic Reticulum-associated Degradation

2000 • 106 citations

Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function.

1988 • 105 citations

Inhibition of Glucose Trimming with Castanospermine Reduces Calnexin Association and Promotes Proteasome Degradation of the α-Subunit of the Nicotinic Acetylcholine Receptor

1998 • 103 citations

Hypothesis: Proteasomal Dysfunction

2002 • 103 citations

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts.

1990 • 102 citations

cDNA Cloning and Baculovirus Expression of the Human Liver Endoplasmic Reticulum P58: Characterization as a Protein Disulfide Isomerase Isoform, but Not as a Protease or a Carnitine Acyltransferase

1995 • 97 citations

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor

1995 • 95 citations

Extracellular domains mediating ɛ subunit interactions of muscle acetylcholine receptor

1991 • 94 citations

Neuronal α-Bungarotoxin Receptors Differ Structurally from Other Nicotinic Acetylcholine Receptors

1997 • 90 citations

The Role of the Cystine Loop in Acetylcholine Receptor Assembly

1997 • 87 citations

Role of the Endoplasmic Reticulum Chaperone Calnexin in Subunit Folding and Assembly of Nicotinic Acetylcholine Receptors

1995 • 81 citations

Mutation causing congenital myasthenia reveals acetylcholine receptor β/δ subunit interaction essential for assembly

1999 • 81 citations

Assembly and N-glycosylation of all ACh receptor subunits are required for their efficient insertion into plasma membranes

1989 • 79 citations

Calnexin-dependent Enhancement of Nicotinic Acetylcholine Receptor Assembly and Surface Expression

1997 • 78 citations

Adjacent Basic Amino Acid Residues Recognized by the COP I Complex and Ubiquitination Govern Endoplasmic Reticulum to Cell Surface Trafficking of the Nicotinic Acetylcholine Receptor α-Subunit

2001 • 75 citations

Acetylcholine receptor assembly is stimulated by phosphorylation of its γ subunit

1991 • 75 citations

Identification of two amino acid residues in the ϵ subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells

1991 • 75 citations

Efficiency of acetylcholine receptor subunit assembly and its regulation by cAMP.

1991 • 74 citations

Fibroblasts transfected with Torpedo acetylcholine receptor beta-, gamma-, and delta-subunit cDNAs express functional receptors when infected with a retroviral alpha recombinant.

1989 • 72 citations

Assembly of Torpedo acetylcholine receptors in Xenopus oocytes.

1991 • 71 citations

Cell-free expression of functional Shaker potassium channels

1992 • 65 citations

Involvement of the Chaperone Protein Calnexin and the Acetylcholine Receptor β-Subunit in the Assembly and Cell Surface Expression of the Receptor

1996 • 62 citations

A Role of the Ubiquitin–Proteasome System in Neuropathic Pain

2002 • 58 citations

BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells

1992 • 58 citations

Acetylcholine receptor in a C2 muscle cell variant is retained in the endoplasmic reticulum.

1989 • 55 citations

An Oxysterol-derived Positive Signal for 3-Hydroxy- 3-methylglutaryl-CoA Reductase Degradation in Yeast

2001 • 54 citations

Analysis of early events in acetylcholine receptor assembly.

1991 • 53 citations

Formation of the Nicotinic Acetylcholine Receptor Binding Sites

1998 • 46 citations

cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.

1991 • 46 citations

The Reported cDNA Sequence for Phospholipase Cα Encodes Protein Disulfide Isomerase, Isozyme Q-2 and Not Phospholipase C

1993 • 45 citations

Host Cell‐Specific Folding of the Neuronal Nicotinic Receptor α8 Subunit

1998 • 41 citations

Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties.

1983 • 39 citations

Blue Native Page as a Useful Method for the Analysis of the Assembly of Distinct Combinations of Nicotinic Acetylcholine Receptor Subunits

1999 • 36 citations

Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line

1996 • 35 citations

The amino acid residues 1–128 in the α subunit of the nicotinic acetylcholine receptor contain assembly signals

1994 • 25 citations

Nicotinic Receptor Assembly Requires Multiple Regions throughout the γ Subunit

1999 • 22 citations

Rearrangement of Nicotinic Receptor α Subunits during Formation of the Ligand Binding Sites

2001 • 18 citations