Gliotoxic Action of Glutamate on Cultured Astrocytes

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

1996 • 1,088 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples

1990 • 901 citations

Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle

1998 • 696 citations

Lactate-Supported Synaptic Function in the Rat Hippocampal Slice Preparation

1988 • 543 citations

Exchange of cystine and glutamate across plasma membrane of human fibroblasts.

1986 • 499 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

1980 • 409 citations

Energy-requiring cell functions in the ischemic brain

1982 • 408 citations

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats

1997 • 285 citations

Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation

1997 • 258 citations

The high affinity uptake system for excitatory amino acids in the brain

1994 • 257 citations

Lactate release from cultured astrocytes and neurons: A comparison

1988 • 253 citations

Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.

1990 • 239 citations

The elusive transporters with a high affinity for glutamate

1993 • 195 citations

PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS OF ASTROCYTIC SWELLING

1986 • 193 citations

Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux

1986 • 187 citations

Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain

1999 • 179 citations

Regulation of Energy Metabolism in Synaptic Terminals and Cultured Rat Brain Astrocytes: Differences Revealed Using Aminooxyacetate

1993 • 170 citations

The Early Reactions of Non-Neuronal Cells to Brain Injury

1994 • 167 citations

Astrocytic Swelling Due to Hypotonic or High K⁺Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release

1995 • 161 citations

Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.

2000 • 137 citations

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1992 • 135 citations

Glutamate-evoked release of arachidonic acid from mouse brain astrocytes

1994 • 129 citations

Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons

1996 • 121 citations

Astrocytes in glutamate neurotransmission

1995 • 121 citations

Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain

1991 • 112 citations

Mechanisms of glial swelling induced by glutamate

1992 • 101 citations

Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures

1995 • 95 citations

Ionic mechanisms in glutamate-induced astrocyte swelling: Role of K+ influx

1998 • 94 citations

Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.

1994 • 88 citations

Sodium‐dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat

1995 • 74 citations

Electrophysiological properties of glial cells: comparison of brain slices with primary cultures

1988 • 66 citations

Reactive oxygen species involved in the glutamate toxicity of C6 glioma cells via XC¯ antiporter system

1996 • 59 citations

Gliotoxic actions of excitatory amino acids

1992 • 48 citations

Glial changes in the progress of a chemical lesion. An electron microscopic study

1976 • 38 citations

Extracellular Intermediates of Glucose Metabolism: Fluxes of Endogenous Lactate and Alanine Through Extracellular Pools in Embryonic Sympathetic Ganglia

1992 • 23 citations