Metal complexing agents as therapies for Alzheimer’s disease

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1999 • 1,787 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

2001 • 1,264 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

1999 • 1,070 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

1999 • 748 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

2001 • 643 citations

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

2000 • 617 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

2002 • 566 citations

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

1999 • 548 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

2000 • 526 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

1999 • 481 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Metal Binding Modes of Alzheimer's Amyloid β-Peptide in Insoluble Aggregates and Soluble Complexes

2000 • 449 citations

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

2002 • 419 citations

GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei

1999 • 411 citations

Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

2000 • 389 citations

Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid

1993 • 383 citations

Redox-active iron mediates amyloid-β toxicity

2001 • 376 citations

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

2002 • 348 citations

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

2000 • 339 citations

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1994 • 329 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

2000 • 321 citations

Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease

1989 • 319 citations

Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

1997 • 307 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

Enzyme Activities in Relation to pH and Lactate in Postmortem Brain in Alzheimer‐Type and Other Dementias

1990 • 252 citations

The βA4 amyloid precursor protein binding to copper

1994 • 244 citations

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

1990 • 243 citations

Metal Chelation as a Potential Therapy for Alzheimer's Disease

2000 • 211 citations

Differential degeneration of the cerebral microvasculature in Alzheimerʼs disease

1995 • 205 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

Role of Free Radicals and Metal Ions in the Pathogenesis of Alzheimer’s Disease

2018 • 180 citations

Evidence for release of copper in the brain: Depolarization‐induced release of newly taken‐up ⁶⁷copper

1988 • 179 citations

Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

2001 • 179 citations

Histochemically Reactive Zinc in Plaques of the Swedish Mutant β-Amyloid Precursor Protein Transgenic Mice

1999 • 132 citations

Changes in uptake of vitamin B12 and trace metals in brains of mice treated with clioquinol

2000 • 125 citations

Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process.

1988 • 123 citations

Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations

1999 • 109 citations

Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67-copper

1988 • 100 citations

Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin.

1983 • 96 citations

Copper catalyzed oxidation of Alzheimer Abeta.

2000 • 89 citations

Role of glycine-33 and methionine-35 in Alzheimer’s amyloid β-peptide 1–42-associated oxidative stress and neurotoxicity

2002 • 83 citations

The Structure of Neuritic Plaques in the Cerebral Cortex of Aged Rats

1981 • 78 citations

5 The Present Status of Chelating Agents in Medicine

1983 • 71 citations

The neurotoxicity of zinc in the rat hippocampus

1990 • 57 citations

Oxidative damage in Alzheimer’s disease

2015 • 56 citations

⁶⁵Zn Uptake from Blood into Brain in the Rat

1991 • 34 citations

The Binding of Receptor-recognized α2-Macroglobulin to the Low Density Lipoprotein Receptor-related Protein and the α2M Signaling Receptor Is Decoupled by Oxidation

1997 • 31 citations

Effects of 2,2′-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function

1980 • 31 citations

Discussion

1999 • 31 citations

65Zinc uptake from blood into brain and other tissues in the rat

1990 • 26 citations

THE EFFECTS OF DISULFIRAM ON EQUINE HEPATIC ALCOHOL DEHYDROGENASE AND ITS EFFICIENCY AGAINST ALCOHOLISM: VINEGAR EFFECT

1996 • 11 citations