2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: Partial antagonism and mechanistic studies

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions

1980 • 827 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

1974 • 326 citations

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 251 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Interaction of the Ah and hr loci

1982 • 156 citations

Immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in strains of mice with different susceptibility to induction of aryl hydrocarbon hydroxylase

1983 • 143 citations

Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness

1980 • 104 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Induction

1974 • 103 citations

Liquid-chromatographic analysis for urinary porphyrins.

1981 • 85 citations

Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse.

1973 • 79 citations

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.

1988 • 73 citations

Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448

1984 • 70 citations

Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in mice

1984 • 68 citations

Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins

1981 • 64 citations

Immunoreactive uroporphyrinogen decarboxylase is unchanged in porphyria caused by TCDD and hexachlorobenzene

1982 • 62 citations

Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria

1983 • 60 citations

6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice

1989 • 57 citations

Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide

1986 • 55 citations

Tissue porphyrin pattern determination by high-speed high-performance liquid chromatography

1986 • 51 citations

Hepatic toxicity and uroporphyrinogen decarboxylase activity following a single dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin to mice

1981 • 48 citations

Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1982 • 47 citations

Porphyrogenic effect of chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats. Dose-effect relationship following urinary excretion of porphyrins

1981 • 45 citations

Association between induction of aryl hydrocarbon hydroxylase and depression of uroporphyrinogen decarboxylase activity.

1977 • 34 citations

The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation

1979 • 31 citations

Studies on porphyrin metabolism in the kidney. Effects of trace metals and glutathione on renal uroporphyrinogen decarboxylase.

1984 • 29 citations

Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds

1988 • 19 citations

Continued depression of hepatic uroporphyrinogen decarboxylase activity caused by hexachlorobenzene or 2,3,7,8-tetrachlorodibenzo-p-dioxin despite regeneration after partial hepatectomy

1985 • 8 citations

Role of inhibition of uroporphyrinogen decarboxylase in PCB-induced porphyria in mice

1987 • 7 citations