The Four R's of Radiotherapy

Radiation Response of Mammalian Cells Grown in Culture I. Repair of X-Ray Damage in Surviving Chinese Hamster Cells

2012 • 728 citations

Variations in Several Responses of HeLa Cells to X-Irradiation during the Division Cycle

1963 • 592 citations

Radiation Response of Mammalian Cells Grown in Culture: I. Repair of X-Ray Damage in Surviving Chinese Hamster Cells

1960 • 542 citations

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

1972 • 296 citations

Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation

1969 • 274 citations

Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays

1970 • 260 citations

Changes in the rate of repopulation during multifraction irradiation of mouse skin

1973 • 247 citations

Cellular Radiation Biology

1965 • 234 citations

Radiosensitivity and Fractionation Response of Crypt Cells of Mouse Jejunum

1969 • 232 citations

Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy

1960 • 222 citations

Radiation Survival and Regeneration Characteristics of Spermatogenic Stem Cells of Mouse Testis

1974 • 192 citations

Rates of Growth of Pulmonary Metastases and Host Survival

1964 • 188 citations

An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C₃H mouse mammary tumours

1969 • 183 citations

Radiosensitivity of capillary endothelium

1973 • 164 citations

The Effect of Divided Doses of 15 MeV Electrons on the Skin Response of Mice

1965 • 147 citations

Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle

1974 • 144 citations

Recovery and Repopulation in Vivo by Mouse Skin Epithelial Cells during Fractionated Irradiation

1967 • 144 citations

Cellular recovery in human skin reactions: Application to dose fraction number overall time relationship in radiotherapy

1973 • 127 citations

A pH-Induced Structural Change in Bromegrass Mosaic Virus

1964 • 123 citations

The kinetics of recovery in irradiated colonic mucosa of the mouse

1974 • 123 citations

Survival of Mouse Skin Epithelial Cells Following Single and Divided Doses of X-Rays

1970 • 115 citations

REPAIR PROCESSES IN IRRADIATED MOUSE HEMATOPOIETIC TISSUE*

1964 • 88 citations

Dose-Survival Characteristics of Epithelial Cells of Mouse Intestinal Mucosa

1968 • 78 citations

Recovery and repopulation in mouse skin as a function of time after x-irradiation.

1969 • 77 citations

The relative effects of fast neutrons and X rays on tumour and normal tissue in the rat. Part II. Fractionation: recovery and reoxygenation

1968 • 70 citations

Cell Survival and Radiation Damage in Growth Cartilage

1967 • 70 citations

Cell Proliferation Studies in the Intestinal Epithelium of the Rat: Response to Continuous Irradiation

1967 • 68 citations

Preferential Radiosensitization of Mouse Sarcoma Relative to Normal Skin by Chronic Intra-Arterial Infusion of Halogenated Pyrimidine Analogs<xref ref-type="fn" rid="FN2">2</xref>

1971 • 63 citations

Recovery and Repopulation in Mouse Skin as a Function of Time after X-Irradiation

1969 • 60 citations

The Age Sensitivity of Epithelial Cells of Mouse Small Intestine

1970 • 56 citations

Some Physical Aspects of Relative Biological Efficiency

1957 • 54 citations

Repair of Sublethal Radiation Injury in Hypoxic Cells of a C 3 H Mouse Mammary Carcinoma

1969 • 53 citations

Effect of Fractionation of Radiation Dose on Callus Formation at Site of Fracture

1971 • 49 citations

A Quantitative Technique for Measuring Renal Damage After Irradiation

1973 • 49 citations

The effect of acute x-irradiation on the cell proliferation kinetics of induced carcinomas and their normal counterpart.

1970 • 46 citations

Survival Characteristics of Stem Cells of Gastric Mucosa in C₃H Mice Subjected to Localized Gamma Irradiation

1972 • 43 citations

The effect of hypoxia during irradiation on four-day death in mice given single and split doses of electrons

1968 • 38 citations

The Effect of Acute X-Irradiation on the Cell Proliferation Kinetics of Induced Carcinomas and Their Normal Counterpart

1970 • 36 citations

Radiation Dose Fractionation and Tumor Control Probability

1966 • 32 citations

AGE RESPONSE TO X-RADIATION OF MURINE LYMPHOMA CELLS SYNCHRONIZED in vivo

1969 • 31 citations

Dose-Effect Relationships for Radiation Damage to Organized Tissues

1963 • 31 citations

Effect of Fractionation of Radiation Dose on Skin Contraction and Skin Reaction of Swiss Mice

1972 • 30 citations

Macro-colony Assay for Measurement of Reparative Angiogenesis after X-irradiation

1972 • 26 citations

Normal Tissue Damage and Tumor Cure Probability for Irradiation Given Under Different Conditions of Tissue Oxygenation in Hybrid Mice

1967 • 26 citations

On the relative importance of hypoxic cells for the radiotherapy of human tumours

1974 • 25 citations

Effect of Dose Size on Rate of Recovery from Radiation Damage in Mice

1961 • 25 citations

Split-Dose Recovery in Euoxic and Hypoxic Normal and Tumor Cells

1972 • 24 citations

Cell Renewal System Concepts and the Radiation Response

2015 • 23 citations

The proliferation and spread of neoplastic cells

1966 • 23 citations

Radiation depigmentation of mouse hair: split-dose experiments and melanocyte precursors (amelanotic melanoblasts) in the resting hair follicle.

1970 • 18 citations

The Effect of Dose-rate and Fractionation on Acute Mortality in X-irradiated Mice. Part II

1962 • 18 citations

Cell population kinetics in radiation therapy: Optimization of tumor dosage

1973 • 17 citations

Intracellular Repair and the Oxygen Effect in Radiobiology and Radiotherapy

2015 • 17 citations

Correspondence

1967 • 15 citations

Radiation Depigmentation of Mouse Hair: Split-Dose Experiments and Melanocyte Precursors (Amelanotic Melanoblasts) in the Resting Hair Follicle

1970 • 14 citations

Proliferation and Differentiation of Gastrointestinal Cells in Relation to Therapy

1971 • 13 citations

Theoretical Considerations of Dose Rate Factors Influencing Radiation Strategy

1974 • 11 citations

Poor man's neutrons?

1971 • 8 citations

X-Irradiation of the Hematopoietic Stem Cell Compartment1

2015 • 7 citations

Altered split-dose recovery in mice irradiated under hypoxic conditions.

1969 • 6 citations

Altered Split-Dose Recovery in Mice Irradiated under Hypoxic Conditions

1969 • 6 citations

The Radiation Sensitivity of Normal and Polyoma-Transformed Rat Embryo Cells

1966 • 4 citations