Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

Cellular forms and functions of brain microglia

1994 • 349 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Monoclonal antibodies that define canine homologues of human CD antigens: Summary of the First International Canine Leukocyte Antigen Workshop (CLAW)

1994 • 247 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

Functional roles of microglia in the brain

1993 • 209 citations

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

1990 • 207 citations

Microglia: Immune Network in the CNS

1990 • 200 citations

Surveillance, Intervention and Cytotoxicity: Is There a Protective Role of Microglia?

1994 • 185 citations

Inflammatory cytokines in the brain: Does the CNS shape immune responses?

1994 • 180 citations

Astrocytes of the brain synthesize interleukin 3-like factors.

1985 • 177 citations

Experimental models of virus‐induced demyelination of the central nervous system

1982 • 174 citations

Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study

1990 • 145 citations

The regulation of expression of major histocompatibility complex products.

1986 • 144 citations

Observations on viral demyelinating encephalomyelitis. Canine distemper.

1972 • 125 citations

Absence of MHC class ii molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy

1994 • 112 citations

Effects of canine distemper virus infection on lymphoid function in vitro and in vivo

1975 • 107 citations

Preparation and Characterization of Monoclonal Antibodies Directed against Four Structural Components of Canine Distemper Virus

1985 • 89 citations

The nature of inflammatory components during demyelination in multiple sclerosis

1988 • 85 citations

The glial reaction in the course of axon regeneration: A stereological study of the rat hypoglossal nucleus

1984 • 82 citations

Expression of Adhesion Molecules and Histocompatibility Antigens at the Blood‐Brain Barrier

1991 • 80 citations

On the development of CNS lesions in natural canine distemper encephalomyelitis

1976 • 79 citations

Immunopathology of the lesion in chronic relapsing experimental autoimmune encephalomyelitis in the mouse

1986 • 79 citations

Canine distemper virus clearance in chronic inflammatory demyelination

1986 • 78 citations

Spread and distribution of viral antigen in nervous canine distemper

1985 • 76 citations

Detection of T lymphocytes in canine tissue embedded in paraffin wax by means of antibody to CD3 antigen

1992 • 75 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination

1989 • 69 citations

Studies on canine distemper virus persistence in the central nervous system

1995 • 68 citations

POSSIBLE INITIATION OF VIRAL ENCEPHALOMYELITIS IN DOGS BY MIGRATING LYMPHOCYTES INFECTED WITH DISTEMPER VIRUS

1978 • 63 citations

Microglia Present Myelin Antigens to T Cells after Phagocytosis of Oligodendrocytes

1993 • 60 citations

Immunocytochemical and electron-microscopic characterization of macrophage/microglia cells and expression of class II major histocompatibility complex in the pineal gland of the rat

1993 • 59 citations

Effect of Measles Virus Infection on MHC Class II Expression and antigen Presentation in Human Monocytes

1993 • 55 citations

Studies on the intrathecal humoral immune response in canine distemper encephalitis

1986 • 53 citations

Restricted expression of viral surface proteins in canine distemper encephalitis

1993 • 53 citations

On classification of post-mortem multiple sclerosis plaques for neuroscientists

1993 • 47 citations

Demyelination in canine distemper encephalomyelitis: An ultrastructural analysis

1987 • 40 citations

Demonstration of α, β, and γ Interferon in Active Chronic Multiple Sclerosis Lesionsa

1988 • 39 citations

Canine distemper virus: the early blood-brain barrier lesion

1987 • 36 citations

The Immunopathology of Acute Experimental Allergic Encephalomyelitis. IV. An Ultrastructural Immunocytochemical Study of Class II Major Histocompatibility Complex Molecule (Ia) Expression

1987 • 36 citations

Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions☆

1983 • 33 citations

A CD3+CD8+ T Cell Population Lacking CD5 Antigen Expression Is Expanded in Peripheral Blood of Human Immunodeficiency Virus-Infected Patients

1995 • 30 citations

Induction of MHC class II antigen expression on murine microglia by interleukin-3

1994 • 29 citations

Evidence of oligodendrocyte infection and degeneration in canine distemper encephalomyelitis

1989 • 25 citations

Measles Virus-Induced Autoimmune Reactions against Brain Antigen

1993 • 17 citations

Measles Virus Infection Causes Expression of Class I and Class II MHC Antigens in Rat Brain

1988 • 5 citations