The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

2001 • 1,180 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

2001 • 1,153 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

2001 • 931 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

2004 • 898 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma

2005 • 831 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Oncogenic PI3K deregulates transcription and translation

2005 • 768 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

The PIK3CA gene is mutated with high frequency in human breast cancers

2004 • 654 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas

2004 • 510 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells

2005 • 469 citations

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

2001 • 457 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers

2005 • 412 citations

Cancer-specific mutations in PIK3CA are oncogenic in vivo

2006 • 409 citations

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

2007 • 389 citations

Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer

2005 • 367 citations

Akt-Dependent Phosphorylation of p21^Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells

2001 • 357 citations

Rare cancer-specific mutations in PIK3CA show gain of function

2007 • 352 citations

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

2004 • 340 citations

The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

2005 • 315 citations

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1998 • 265 citations

Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas

2003 • 233 citations

Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21

2000 • 188 citations

Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase

1998 • 174 citations

Cancer-specific mutations in phosphatidylinositol 3-kinase

2007 • 138 citations

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

1996 • 129 citations

Chemically targeting the PI3K family

2007 • 127 citations

Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

2002 • 125 citations

PIK3CA mutations in advanced ovarian carcinomas

2005 • 119 citations

Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit

2005 • 84 citations

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

1993 • 52 citations

Genetic polymorphisms in the transforming growth factor beta-induced gene associated with BMI

2005 • 16 citations