Rare cancer-specific mutations in PIK3CA show gain of function
Data up to Jan 2025
Total Citations Per Year
Abstract
References (32)
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 • 29,943 citations
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 • 3,304 citations
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 • 3,099 citations
Current development of mTOR inhibitors as anticancer agents
2006 • 970 citations
Mutation of the PIK3CA Gene in Ovarian and Breast Cancer
2004 • 898 citations
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005 • 873 citations
PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
2005 • 831 citations
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
2005 • 813 citations
Oncogenic PI3K deregulates transcription and translation
2005 • 768 citations
The PIK3CA gene is mutated with high frequency in human breast cancers
2004 • 654 citations
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
2006 • 587 citations
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
2004 • 510 citations
Oncogenic Mutations of PIK3CA in Human Cancers
2004 • 502 citations
Mutation of the PIK3CA oncogene in human cancers
2006 • 478 citations
Structural insights into phosphoinositide 3-kinase catalysis and signalling
1999 • 478 citations
Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells
2005 • 469 citations
mTOR and cancer therapy
2006 • 460 citations
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
2005 • 412 citations
Cancer-specific mutations in PIK3CA are oncogenic in vivo
2006 • 409 citations
Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer
2005 • 367 citations
Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas
2004 • 340 citations
The prevalence of PIK3CA mutations in gastric and colon cancer
2005 • 333 citations
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
2005 • 315 citations
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
2005 • 227 citations
Characteristics of two new avian tumor virus subgroups
1969 • 227 citations
Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.
1990 • 175 citations
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.
1991 • 123 citations
Phosphoinositide 3-kinases as drug targets in cancer
2005 • 105 citations
Telomerase RNA Mutated in Autosomal Dyskeratosis Congenita Reconstitutes a Weakly Active Telomerase Enzyme Defective in Telomere Elongation
2005 • 87 citations
The Catalytic Subunit of Phosphoinositide 3-Kinase: Requirements for Oncogenicity
2000 • 85 citations
Mutated PI 3-Kinases: Cancer Targets on a Silver Platter
2005 • 62 citations
Human Tumor Mutants in PI3K p110α Subunit
2006 • 46 citations
Cited By (0)
No citing papers found in database