ω- and (ω − 1) -hydroxylation of arachidonic acid, lauric acid and prostaglandin A1 by multiple forms of cytochrome P-450 purified from rat hepatic microsomes

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.

1982 • 251 citations

Sex difference of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats

1983 • 233 citations

Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls

1982 • 217 citations

Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase

1989 • 164 citations

The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid.

1982 • 161 citations

Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography

1985 • 156 citations

Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid

1982 • 147 citations

Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5

1983 • 132 citations

Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats

1987 • 107 citations

A prostaglandin omega-hydroxylase cytochrome P-450 (P-450PG-omega) purified from lungs of pregnant rabbits.

1984 • 102 citations

Biosynthesis of 19‐Hydroxy‐Prostaglandin A₁

1969 • 99 citations

cDNA cloning and inducible expression during pregnancy of the mRNA for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome P-450p-2).

1987 • 92 citations

Structure of the major urinary metabolite of prostaglandin E2 in man

1969 • 91 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

Purification and characterization of a new form (RLM2) of liver microsomal cytochrome P-450 from untreated rat.

1985 • 85 citations

The omega- and (omega-1)-hydroxylase activities of prostaglandins A1 and E1 and lauric acid by pig kidney microsomes and a purified kidney cytochrome P-450.

1981 • 74 citations

Constitutive Testosterone 6β-Hydroxylase in Rat Liver

1988 • 73 citations

Formation of n-hexanedioic acid from hexadecanoic acid by an initial ω oxidation in ketotic rats

1972 • 66 citations

Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography

1988 • 56 citations

Purification and characterization of two constitutive cytochromes P-450 (F-1 and F-2) from adult female rats: identification of P-450F-1 as the phenobarbital-inducible cytochrome P-450 in male rat liver

1987 • 52 citations

Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450

1985 • 49 citations

Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats

1988 • 39 citations

Purification and Characterization of Six Cytochromes P-450 from Hepatic Microsomes of Immature Female Rats

1987 • 35 citations

A fatty acid gamma-hydroxylation system solubilized from porcine kidney cortex microsomes.

1971 • 33 citations

A fatty acid ω-hydroxylation system solubilized from porcine kidney cortex microsomes

1971 • 32 citations

On the rate-limiting step in ω-hydroxylation of lauric acid

1972 • 29 citations

A Reevaluation of the Role of Cytochrome P-4S0 as the Terminal Oxidase in Hepatic Microsomal Mixed Function Oxidase Catalyzed Reactions

1979 • 28 citations

Regioselective hydroxylation of prostaglandins by constitutive forms of cytochrome P-450 from rat liver: Formation of a novel metabolite by a female-specific P-450

1988 • 24 citations

Hydroxylation of Prostaglandin A1 by the Microsomes of Rabbit Intestinal Mucosa1

1984 • 24 citations

Isolation by ion-exchange high performance liquid chromatography of rabbit liver cytochrome P-450 with regioselectivity for omega-hydroxylation of prostaglandins.

1985 • 24 citations