Second messenger role for NO widens to nervous and immunesystem

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

1986 • 272 citations