Major histocompatibility complex class II– fetal skin dendritic cells are potent accessory cells of polyclonal T‐cell responses

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Co-stimulation in T cell responses

1997 • 430 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.

1994 • 378 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

The role of B7 co‐stimulation in activation and differentiation ofCD4⁺and CD8⁺T cells

1998 • 306 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Cytokine‐related syndrome following injection of anti‐CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation

1990 • 267 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

1996 • 201 citations

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

1989 • 198 citations

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3.

1987 • 188 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses.

1988 • 172 citations

Role of cytokines in epidermal Langerhans cell migration

1999 • 172 citations

Accessory Cell Signals Involved in T‐Cell Activation

1990 • 160 citations

Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells

1988 • 147 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Mechanisms by which accessory cells contribute in growth of resting T lymphocytes initiated by OKT3 antibody

1985 • 126 citations

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

1995 • 125 citations

The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes

1985 • 120 citations

ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1

1999 • 120 citations

Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells

2000 • 114 citations

An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells.

1989 • 113 citations

Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes.

1984 • 95 citations

T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fc gamma receptors for murine IgG2a and inability to cross-link the T3-Ti complex.

1985 • 90 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Hypothermia and hypoglycemia induced by anti‐CD3 monoclonal antibody in mice: Role of tumor necrosis factor

1990 • 83 citations

The murine IL 2 receptor. III. Cellular requirements for the induction of IL 2 receptor expression on T cell subpopulations.

1985 • 79 citations

B7‐1‐dependent co‐stimulation results in qualitatively and quantitatively different responses by CD4⁺ and CD8⁺ T cells

1997 • 77 citations

Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells.

1985 • 72 citations

A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes.

1989 • 68 citations

Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes.

1989 • 63 citations

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells

1997 • 63 citations

Mitogenic actions of orthoclone OKT3 on human peripheral blood lymphocytes: Effects of monocytes and serum components

1981 • 59 citations

Fetal skin-derived MHC class I+, MHC class II- dendritic cells stimulate MHC class I-restricted responses of unprimed CD8+ T cells.

1994 • 55 citations

Purified MHC Class I and Peptide Complexes Activate Naive CD8+ T Cells Independently of the CD28/B7 and LFA-1/ICAM-1 Costimulatory Interactions

1998 • 50 citations

Role of co-stimulation in CD8+ T cell activation

1998 • 50 citations

Fc receptors on monocytes cause OKT3-treated lymphocytes to internalize T3 and to secrete IL-2

1986 • 48 citations

Mitogenic stimulation of T cells reveals differing contributions for B7‐1 (CD80) and B7‐2 (CD86) costimulation

1997 • 47 citations

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.

1997 • 47 citations

Fc receptor binding of anti‐CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine‐related side effects

1995 • 42 citations

T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor.

1992 • 42 citations

OKT3 F(ABʼ)2 FRAGMENTS—RETENTION OF THE IMMUNOSUPPRESSIVE PROPERTIES OF WHOLE ANTIBODY WITH MARKED REDUCTION IN T CELL ACTIVATION AND LYMPHOKINE RELEASE

1991 • 41 citations

Functional Human Epidermal Langerhans Cells that Lack Birbeck Granules

1994 • 39 citations

Development of ATPase-positive, immature Langerhans cells in the fetal mouse epidermis and their maturation during the early postnatal period

1987 • 35 citations

T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: Evidence for two different modes of activation

1989 • 33 citations

Immunologic function of endothelial cells: guinea pig aortic endothelial cells support mitogen-induced T lymphocyte activation, but do not function as antigen-presenting cells.

1984 • 30 citations

Accessory function and interleukin 1 production by human leukemic cell lines.

1984 • 30 citations

Accessory function of human thymic dendritic cells in Con A-induced proliferation of autologous thymocyte subsets.

1990 • 28 citations

Differences in the stimulating capacity of immobilized anti-CD3 monoclonal antibodies: variable dependence on interleukin-1 as a helper signal for T-cell activation.

1991 • 27 citations

The role of accessory cells in polyclonal T cell activation III. No requirement for recognition of H‐2‐encoded antigens on accessory cells

1984 • 27 citations

Modulation of T cell proliferative responses by accessory cell interactions

1994 • 20 citations

Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant.

1989 • 17 citations

Differential effects of B7-1 and B7-2 on the costimulation of mouse nonspecific cytotoxic T lymphocyte development in response to anti-CD3 antibody

1999 • 10 citations

A polymorphic Fc receptor for mouse IgG2b on human B cells and monocytes.

1991 • 9 citations

T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies.

1991 • 7 citations

Different Requirements of CD3 Cross-Linkage for the Activation of Memory and Naive CD8+ T Cells

1994 • 5 citations

Isolation of T cells from mouse and human skin

1996 • 2 citations

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