Dephosphorylation of Histone γ-H2AX during Repair of DNA Double-Strand Breaks in Mammalian Cells and its Inhibition by Calyculin A

The language of covalent histone modifications

2000 • 8,260 citations

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly

2002 • 1,088 citations

Protein phosphatase 1 – targeted in many directions

2002 • 911 citations

Histone H2A variants H2AX and H2AZ

2002 • 749 citations

Kinetics of Core Histones in Living Human Cells

2001 • 669 citations

A role for Saccharomyces cerevisiae histone H2A in DNA repair

2000 • 647 citations

Dynamic binding of histone H1 to chromatin in living cells

2000 • 606 citations

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

2002 • 529 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

2000 • 459 citations

Rapid exchange of histone H1.1 on chromatin in living human cells

2000 • 405 citations

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

2001 • 392 citations

Reversible histone modification and the chromosome cell cycle

1992 • 357 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

25 years after the nucleosome model: chromatin modifications

2000 • 338 citations

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

1997 • 297 citations

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

1999 • 295 citations

Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

2001 • 275 citations

Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation

2001 • 246 citations

Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells

2002 • 236 citations

Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

2001 • 214 citations

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

2001 • 204 citations

Initial Steps of Ferulic Acid Polymerization by Lignin Peroxidase

2001 • 199 citations

Recruitment of Phosphorylated Chromatin Assembly Factor 1 to Chromatin after UV Irradiation of Human Cells

1998 • 178 citations

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1998 • 160 citations

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells

2001 • 160 citations

Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity

2001 • 157 citations

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens

2000 • 139 citations

Securing genome stability by orchestrating DNA repair: removal of radiation‐induced clustered lesions in DNA

2001 • 107 citations

Reversible Protein Phosphorylation Modulates Nucleotide Excision Repair of Damaged DNA by Human Cell Extracts

1996 • 87 citations

Accessing DNA damage in chromatin: Insights from transcription

1999 • 64 citations

Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus

2002 • 57 citations

Ionizing Radiation Activates Nuclear Protein Phosphatase-1 by ATM-dependent Dephosphorylation

2002 • 53 citations

SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells

1997 • 51 citations

Requirement of Cyclin/Cdk2 and Protein Phosphatase 1 Activity for Chromatin Assembly Factor 1-dependent Chromatin Assembly during DNA Synthesis

2000 • 44 citations

Visualization of Focal Nuclear Sites of DNA Repair Synthesis Induced by Bleomycin in Human Cells

2001 • 43 citations

Phosphatase Inhibitors and Premature Chromosome Condensation in Human Peripheral Lymphocytes at Different Cell-Cycle Phases

1999 • 38 citations

In Vitro Studies on the Maintenance of Transcription-induced Stress by Histones and Polyamines

2000 • 31 citations

Abnormal pattern of post-γ-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome

1995 • 27 citations

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication

2000 • 25 citations

Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor calyculin A.

1994 • 16 citations

Factors influencing the removal of thymine glycol from DNA in γ-irradiated human cells

2001 • 12 citations