The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

1983 • 618 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+.

1988 • 566 citations

[72] Identification of regulatory elements of cloned genes with functional assays

1987 • 477 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

1991 • 401 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 371 citations

Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA.

1991 • 334 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element

1989 • 311 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.

1985 • 298 citations

Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

1992 • 285 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

5-Methyl-urapidil discriminates between subtypes of the α1-adrenoceptor

1988 • 208 citations

Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression.

1988 • 185 citations

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors

1989 • 173 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene

1991 • 161 citations

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

1992 • 157 citations

Alpha 1‐adrenergic effects on intracellular pH and calcium and on myofilaments in single rat cardiac cells.

1992 • 130 citations

The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways

1991 • 125 citations

Function of myocardial α-adrenoceptors

1990 • 119 citations

The gene for rat atrial natriuretic factor.

1985 • 113 citations

Pharmacologic characterization of cloned α1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype

1992 • 107 citations

Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity.

1990 • 80 citations

Molecular Advances in Cardiovascular Biology

1993 • 71 citations

Guanine nucleotide-dependent inositol trisphosphate formation in chick heart cells.

1988 • 64 citations

?1B- but not ?1A-adrenoceptors mediate inositol phosphate generation

1990 • 59 citations

Different pathways of [3H]inositol phosphate formation mediated by alpha 1a- and alpha 1b-adrenergic receptors.

1990 • 59 citations

Alpha 1-adrenergic receptor subtypes and formation of inositol phosphates in dispersed hepatocytes and renal cells.

1990 • 52 citations

Adrenergic regulation of glucose metabolism in rat heart. A calcium-dependent mechanism mediated by both alpha- and beta-adrenergic receptors.

1984 • 45 citations

Nucleotide sequence of full length cDNAs encoding rat cardiac myosin light chain-2

1988 • 39 citations

Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures.

1990 • 39 citations

Demonstration of α1A-and α1B-adrenoceptor binding sites in human brain tissue

1989 • 37 citations

Identification and structural characterization of alpha 1-adrenergic receptor subtypes.

1990 • 34 citations

Cardiac α1-adrenoceptors mediate positive inotropy via myofibrillar sensitization

1992 • 24 citations

?1A and ?1B-adrenoceptors enhance inositol phosphate generation in rat renal cortex

1993 • 22 citations

The effect of reserpine, desipramine and thyroid hormone on alpha 1a‐ and alpha 1b‐adrenoceptor binding sites: evidence for a subtype‐ specific regulation.

1990 • 21 citations

α‐ and β‐Adrenoceptors in Hypertension: Molecular Biology and Pharmacological Studies

1992 • 21 citations