Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders.

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Codon usage and tRNA content in unicellular and multicellular organisms.

1985 • 1,724 citations

A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.

1985 • 1,064 citations

Estimation of evolutionary distance between nucleotide sequences.

1984 • 945 citations

Evidence for higher rates of nucleotide substitution in rodents than in man.

1985 • 933 citations

An evolutionary perspective on synonymous codon usage in unicellular organisms

1986 • 874 citations

Rates of DNA Sequence Evolution Differ Between Taxonomic Groups

1986 • 793 citations

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution

1977 • 666 citations

Mutation rates differ among regions of the mammalian genome

1989 • 593 citations

"Silent" sites in Drosophila genes are not neutral: evidence of selection among synonymous codons.

1988 • 535 citations

An evaluation of the molecular clock hypothesis using mammalian DNA sequences

1987 • 453 citations

The molecular clock runs more slowly in man than in apes and monkeys

1987 • 383 citations

Variances of the average numbers of nucleotide substitutions within and between populations.

1989 • 332 citations

Methods for computing the standard errors of branching points in an evolutionary tree and their application to molecular data from humans and apes.

1985 • 316 citations

On the rate of DNA sequence evolution inDrosophila

1989 • 300 citations

Male-driven Molecular Evolution: A Model and Nucleotide Sequence Analysis

1987 • 293 citations

Molecular phylogeny of Rodentia, Lagomorpha, Primates, Artiodactyla, and Carnivora and molecular clocks.

1990 • 253 citations

Nucleotide sequence divergence and functional constraint in mRNA evolution.

1980 • 249 citations

Phylogeny of the major tetrapod groups: Morphological data and divergence dates

1990 • 239 citations

Primate η-globin DNA sequences and man's place among the great apes

1986 • 224 citations

The molecular clock may be an episodic clock.

1984 • 222 citations

Molecular evolutionary clock and the neutral theory

1987 • 177 citations

A statistical test of phylogenies estimated from sequence data.

1989 • 107 citations

VARIABILITY OF EVOLUTIONARY RATES OF DNA

1986 • 91 citations

The compositional distribution of coding sequences and DNA molecules in humans and murids

1988 • 89 citations

Inferring the number of evolutionary events from DNA coding sequence differences.

1989 • 87 citations

The pattern of mammalian evolution and the relative rate of molecular evolution.

1990 • 85 citations

Estimating the variability of substitution rates.

1989 • 69 citations

DNA microenvironments and the molecular clock

1989 • 62 citations

Rate constancy of globin gene evolution in placental mammals.

1988 • 42 citations