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Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction

Data up to Jan 2025

Published1994
Citations34
References31

Total Citations Per Year

Abstract

References (31)

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain

1986 • 312 citations

Nicotinic and muscarinic subtypes in the human brain: Changes with aging and dementia

1992 • 269 citations

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol

1992 • 177 citations

Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

1991 • 145 citations

Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes

1991 • 96 citations

Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?

1990 • 88 citations

Muscarinic receptor compensation in hippocampus of Alzheimer patients

1983 • 85 citations

Impaired phosphoinositide hydrolysis in Alzheimer's disease brain

1994 • 74 citations

Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors

1993 • 67 citations

Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease

1991 • 65 citations

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

1987 • 64 citations

Cholinergic therapy in dementia

2009 • 64 citations

Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease

1993 • 62 citations

Vagal and sympathetic components of conditioned cardioacceleration in the pigeon

1968 • 61 citations

Transmembrane signaling through phospholipase C in human cortical membranes

1993 • 60 citations

Hyperactivation of Signal Transduction Systems in Alzheimer's Diseasea

1993 • 59 citations

Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats

1986 • 58 citations

Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry

1991 • 53 citations

Decrement of muscarinic receptor-stimulated low-KMGTPase in striatum and hippocampus from the aged rat

1992 • 50 citations

Muscarinic acetylcholine receptor subtype mRNA expression and ligand binding in the aged rat forebrain

1991 • 34 citations

Differential coupling between muscarinic receptors and G-proteins in regions of the rat brain

1990 • 23 citations

Characterization of Low Km GTPase Activity in Rat Brain: Comparison of Opioid and Muscarinic Receptor Stimulation

1988 • 20 citations

Changes in signal transduction in Alzheimer’s disease

1990 • 19 citations

Altered post-receptorial signal transduction mechanism under various stimulation in polymorphonuclear granulocytes of Alzheimer's disease

1990 • 12 citations

Oxidative Stress and the Loss of Muscarinic and Dopaminergic Responsiveness in Senescence

1992 • 2 citations

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