Autophagy in infection

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

2008 • 3,605 citations

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

2007 • 2,035 citations

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

2007 • 1,997 citations

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

2006 • 1,920 citations

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

2008 • 1,899 citations

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

2008 • 1,725 citations

Autophagy Suppresses Tumorigenesis through Elimination of p62

2009 • 1,639 citations

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

2008 • 1,543 citations

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

2008 • 1,424 citations

Autophagic cell death: the story of a misnomer

2008 • 1,373 citations

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

2008 • 1,243 citations

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

2009 • 1,205 citations

Nix is a selective autophagy receptor for mitochondrial clearance

2009 • 1,151 citations

Autophagy Is Required to Maintain Muscle Mass

2009 • 1,148 citations

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

2009 • 1,062 citations

Essential role for Nix in autophagic maturation of erythroid cells

2008 • 1,060 citations

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

2009 • 997 citations

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

2009 • 891 citations

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

2009 • 841 citations

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

2009 • 830 citations

Autophagy, Immunity, and Microbial Adaptations

2009 • 827 citations

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

2009 • 805 citations

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

2009 • 757 citations

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

2009 • 746 citations

Toll-like receptors control autophagy

2008 • 696 citations

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

2008 • 653 citations

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

2009 • 557 citations

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

2009 • 535 citations

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

2008 • 500 citations

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

2009 • 489 citations

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

2008 • 482 citations

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

2009 • 456 citations

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

2009 • 456 citations

Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus

2009 • 449 citations

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

2009 • 438 citations

Listeria monocytogenes ActA-mediated escape from autophagic recognition

2009 • 414 citations

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

2008 • 405 citations

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

2009 • 400 citations

FLIP-mediated autophagy regulation in cell death control

2009 • 390 citations

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

2008 • 370 citations

Autophagic control of listeria through intracellular innate immune recognition in drosophila

2008 • 364 citations

The autophagy geneATG5plays an essential role in B lymphocyte development

2008 • 328 citations

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

2009 • 310 citations

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

2009 • 293 citations

The B Cell Receptor Governs the Subcellular Location of Toll-like Receptor 9 Leading to Hyperresponses to DNA-Containing Antigens

2008 • 265 citations

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

2009 • 257 citations

Enhancing Immunity Through Autophagy

2008 • 256 citations

Autophagy Induction by the Pathogen Receptor CD46

2009 • 239 citations

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

2009 • 223 citations

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

2009 • 220 citations

Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance

2009 • 205 citations

Identification ofAtg5-dependent transcriptional changes and increases in mitochondrial mass inAtg5-deficient T lymphocytes

2009 • 189 citations

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

2008 • 184 citations

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

2009 • 178 citations

Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11

2008 • 155 citations

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

2008 • 150 citations

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

2008 • 143 citations

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

2009 • 136 citations

Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection

2009 • 122 citations

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

2008 • 122 citations

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy

2009 • 120 citations

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death

2008 • 116 citations

Death and Resurrection of the Human IRGM Gene

2009 • 113 citations

Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68

2009 • 80 citations