High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restrictedMycobacterium tuberculosis epitope inM. tuberculosis-infected subjects without disease

Global Burden of Tuberculosis

1999 • 3,009 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination

1997 • 1,028 citations

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

1998 • 844 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Rapid Effector Function in CD8+ Memory T Cells

1997 • 652 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG

1996 • 459 citations

Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.

1998 • 431 citations

Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis

1999 • 361 citations

Human T Cell Responses to the ESAT‐6 Antigen fromMycobacterium tuberculosis

1999 • 301 citations

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

1987 • 287 citations

Protection againstMycobacterium tuberculosisInfection by CD8⁺T Cells Requires the Production of Gamma Interferon

1998 • 229 citations

Adoptive protection of the Mycobacterium tuberculosis-infected lung

1984 • 229 citations

Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC‐Pf7, a Pox‐Vectored, Multiantigen, Multistage Vaccine Candidate forPlasmodium falciparumMalaria

1998 • 225 citations

Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis.

1996 • 215 citations

Sequestration From Immune CD4 ⁺ T Cells of Mycobacteria Growing in Human Macrophages

1993 • 194 citations

Differential T cell responses toMycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors

1998 • 172 citations

Attenuation of HLA-DR Expression by Mononuclear Phagocytes Infected withMycobacterium tuberculosisIs Related to Intracellular Sequestration of Immature Class II Heterodimers

1998 • 169 citations

Immunogenicity of DNA Vaccines Expressing Tuberculosis Proteins Fused to Tissue Plasminogen Activator Signal Sequences

1999 • 161 citations

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.

1996 • 156 citations

Potent Induction of Focused Th1‐Type Cellular and Humoral Immune Responses by RTS,S/SBAS2, a RecombinantPlasmodium falciparumMalaria Vaccine

1999 • 155 citations

Genetic polymorphism within HLA‐A*02: significant allelic variation revealed in different populations

1995 • 149 citations

Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria

1995 • 147 citations

Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.

1997 • 133 citations

CTL Response toMycobacterium tuberculosis: Identification of an Immunogenic Epitope in the 19-kDa Lipoprotein

1998 • 116 citations

Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.

1999 • 102 citations

ELISPOT Assay to Detect Cytokine‐Secreting Murine and Human Cells

2008 • 100 citations

Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.

1994 • 94 citations

Host response to intracellular pathogens

1997 • 93 citations

Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors

1997 • 73 citations

38 000 MW antigen‐specific major histocompatibility complex class I restricted interferon‐γ‐secreting CD8⁺ T cells in healthy contacts of tuberculosis

1998 • 26 citations

Distinct regulation of HLA class II and class I cell surface expression in the THP-1 macrophage cell line after bacterial phagocytosis

1999 • 21 citations