Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Immunoglobulin class switching

1996 • 446 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1999 • 372 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

Revising B Cell Receptors

2000 • 261 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

Editing Disease-Associated Autoantibodies

1997 • 217 citations

Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter

1999 • 209 citations

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1999 • 167 citations

Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B Lymphocytes

2000 • 159 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2

1999 • 145 citations

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

1995 • 143 citations

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

1998 • 138 citations

Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production

2000 • 135 citations

Locus-specific somatic hypermutation in germinal centre T cells

1994 • 134 citations

RAG Reexpression and DNA Recombination at T Cell Receptor Loci in Peripheral CD4+ T Cells

1998 • 124 citations

Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

2000 • 122 citations

Changes in Locus-specific V(D)J Recombinase Activity Induced by Immunoglobulin Gene Products during B Cell Development

1997 • 116 citations

Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation

1998 • 104 citations

Distinctive characteristics of germinal center B cells

1997 • 96 citations

B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection

2000 • 79 citations

Positive selection of thymocytes: the long and winding road

1999 • 71 citations

The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci

1999 • 60 citations

RAG2is regulated differentially in B and T cells by elements 5′ of the promoter

1999 • 53 citations

Receptor Revision in Peripheral T Cells Creates a Diverse Vβ Repertoire

2000 • 51 citations

V(D)J hypermutation and receptor revision: coloring outside the lines

1999 • 49 citations

Chronic Modulation of the TCR Repertoire in the Lymphoid Periphery

1999 • 46 citations

The induction of peripheral tolerance by the chronic activation and deletion of CD4+V beta 5+ cells.

1994 • 45 citations

Cutting Edge: Recombinase-Activating Gene Expression and V(D)J Recombination in CD4+CD3low Mature T Lymphocytes

2000 • 44 citations

Somatic hypermutation of the T cell receptor Vβ gene in microdissected splenic white pulps from HIV-1-positive patients

1998 • 36 citations

Role of the T cell receptor α-chain in superantigen recognition

1996 • 23 citations

Thymic selection events mediated by the pre-TCR do not depend upon a limiting ligand

1995 • 18 citations