The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Induction of Immunological Tolerance by Porcine Liver Allografts

1969 • 826 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

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1996 • 780 citations

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

1996 • 669 citations

Hepatic T cells and liver tolerance

2003 • 650 citations

Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection

2002 • 644 citations

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration

1995 • 539 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Sustained Dysfunction of Antiviral CD8⁺T Lymphocytes after Infection with Hepatitis C Virus

2001 • 496 citations

Murine liver allograft transplantation: Tolerance and donor cell chimerism

1994 • 459 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence

1999 • 419 citations

Bone marrow as a priming site for T-cell responses to blood-borne antigen

2003 • 343 citations

Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction.

1997 • 307 citations

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

1994 • 291 citations

Pancreatic Lymph Nodes Are Required for Priming of β Cell Reactive T Cells in NOD Mice

2002 • 290 citations

Selective Retention of Activated CD8+ T Cells by the Normal Liver

1999 • 256 citations

Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival

1998 • 225 citations

Differentiating between Memory and Effector Cd8 T Cells by Altered Expression of Cell Surface O-Glycans

2000 • 207 citations

Antigen-Specific Primary Activation of CD8+ T Cells Within the Liver

2001 • 204 citations

FULLY ALLOGENEIC LIVER GRAFTING IN RATS INDUCES A STATE OF SYSTEMIC NONREACTIVITY TO DONOR TRANSPLANTATION ANTIGENS

1980 • 177 citations

Mechanisms of L-selectin regulation by activated T cells.

1997 • 174 citations

DELETION OF SPONTANEOUS RAT LIVER ALLOGRAFT ACCEPTANCE BY DONOR IRRADIATION

1995 • 173 citations

The lymphoid liver: Considerations on pathways to autoimmune injury

2001 • 158 citations

Role of primary intrahepatic T‐cell activation in the ‘liver tolerance effect’

2002 • 149 citations

Peripheral deletion of autoreactive CD8⁺ T cells in transgenic mice expressing H‐2K^b in the liver

1995 • 138 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment

1998 • 131 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

CTL access to tissue antigen is restricted in vivo.

1994 • 120 citations

Activation induces rapid and profound alterations in the trafficking of T cells

2000 • 112 citations

EVIDENCE THAT APOPTOSIS OF ACTIVATED T CELLS OCCURS IN SPONTANEOUS TOLERANCE OF LIVER ALLOGRAFTS AND IS BLOCKED BY MANIPULATIONS WHICH BREAK TOLERANCE1

1999 • 105 citations

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

1989 • 104 citations

High-Dose/Activation-Associated Tolerance

1997 • 98 citations

Immunomodulatory Effects of the Liver: Deletion of Activated CD4+ Effector Cells and Suppression of IFN-γ-Producing Cells After Intravenous Protein Immunization

2002 • 98 citations

Death by neglect as a deletional mechanism of peripheral tolerance

1999 • 98 citations

Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking.

1997 • 94 citations

The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding

1989 • 90 citations

Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow–derived cells

2002 • 82 citations

Carboxyfluorescein diacetate succinimidyl ester and the virgin lymphocyte: A marriage made in heaven

1999 • 61 citations

Recirculation, phenotype and functions of lymphocytes in mice treated with monoclonal antibody MEL‐14

1994 • 58 citations

Survival Surgery: Removal of the Spleen or Thymus

1992 • 45 citations

Hepatic inflammation and immunity: A summary of a conference on the function of the immune system within the liver

2000 • 38 citations

The monoclonal antibody MEL‐14 can block lymphocyte migration into a site ofchronic inflammation

1992 • 38 citations

HCV immunology–Death and the maiden T cell

2003 • 33 citations

Regulation of Activator Protein-1 and NF-κB in CD8+ T Cells Exposed To Peripheral Self-Antigens

2001 • 21 citations

IMMUNE DISORDERS OF THE LIVER AND BILE DUCT

1992 • 18 citations

Subverting lymph node trafficking by treatment with the Mel-14 monoclonal antibody to L-selectin does not prevent an effective host response to Sendai virus.

1995 • 15 citations