Metallothionein Inhibits Peroxynitrite-induced DNA and Lipoprotein Damage

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future

2000 • 1,008 citations

Role of reactive oxygen species in apoptosis: implications for cancer therapy

2000 • 756 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Metallothioneins: new functional and structural insights

2000 • 401 citations

Endothelial Nitric Oxide Synthase-Dependent Superoxide Generation from Adriamycin

1997 • 360 citations

Cytochrome c Nitration by Peroxynitrite

2000 • 348 citations

Review: Oxidative Stress and Disease

2000 • 230 citations

Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice.

2000 • 224 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

[27] Syntheses of peroxynitrite: To go with the flow or on solid grounds?

1996 • 206 citations

Metallothionein in radiation exposure: its induction and protective role

1999 • 198 citations

Cloning of Trp1β isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein

1999 • 188 citations

The Antioxidant Function of Metallothionein in the Heart

1999 • 184 citations

Direct Reaction of H2O2with Sulfhydryl Groups in HL-60 Cells: Zinc-Metallothionein and Other Sites

1996 • 139 citations

Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein

1996 • 138 citations

Activation pattern of mitogen‐activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation

1999 • 126 citations

Mitogen-Activated Protein Kinase Pathway Mediates Peroxynitrite-Induced Apoptosis in Human Dopaminergic Neuroblastoma SH-SY5Y Cells

1999 • 124 citations

Ca2+-Independent Permeabilization of the Inner Mitochondrial Membrane by Peroxynitrite Is Mediated by Membrane Protein Thiol Cross-Linking and Lipid Peroxidation

1997 • 121 citations

Antioxidant activity of metallothionein compared with reduced glutathione

1997 • 118 citations

Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca2+-induced inhibition of substrate oxidation

1999 • 116 citations

Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro

1995 • 100 citations

Peroxynitrite Modulates the Activation of p38 and Extracellular Regulated Kinases in PC12 Cells

2000 • 78 citations

Scavenging of peroxynitrite by a phenolic/peroxidase system prevents oxidative damage to DNA¹

1998 • 70 citations

Salicylate inhibits LDL oxidation initiated by superoxide/nitric oxide radicals

1999 • 54 citations