Pharmacokinetic and Metabolism Studies Using Microdialysis Sampling

Microdialysis—Theory and application

1990 • 651 citations

A microdialysis method allowing characterization of intercellular water space in humans

1987 • 649 citations

Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

1990 • 501 citations

Determination of Brain Interstitial Concentrations by Microdialysis

1989 • 410 citations

Application of microdialysis in pharmacokinetic studies.

1997 • 300 citations

Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration

1985 • 299 citations

Brain microdialysis and its application for the study of animal behaviour

1995 • 285 citations

In vivo calibration of microdialysis probes for exogenous compounds

1992 • 218 citations

Intracerebral microdialysis: I. Experimental studies of diffusion kinetics

1989 • 218 citations

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

1997 • 215 citations

Continuous in Vivo Monitoring of Amino Acid Neurotransmitters by Microdialysis Sampling with Online Derivatization and Capillary Electrophoresis Separation

1995 • 183 citations

Microdialysis calibration using retrodialysis and zero-net flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus.

1993 • 175 citations

Online Coupling of in vivo Microdialysis Sampling with Capillary Electrophoresis

1994 • 166 citations

A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis

1991 • 161 citations

Intracerebral microdialysis: II. mathematical studies of diffusion kinetics

1989 • 158 citations

The effect of inhibition of synthesis, release, metabolism and uptake on the microdialysis extraction fraction of dopamine

1994 • 151 citations

The spinal loop dialysis catheter: characterization of use in the unanesthetized rat

1995 • 146 citations

Quantitative Microdialysis: Analysis of Transients and Application to Pharmacokinetics in Brain

1991 • 136 citations

Quantitative in Vivo Monitoring of Primary Amines in Rat Caudate Nucleus Using Microdialysis Coupled by a Flow-Gated Interface to Capillary Electrophoresis with Laser-Induced Fluorescence Detection

1996 • 129 citations

The use of an “internal standard” for control of the recovery in microdialysis

1991 • 123 citations

Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans

1996 • 121 citations

On-Line Microdialysis Sample Cleanup for Electrospray Ionization Mass Spectrometry of Nucleic Acid Samples

1996 • 120 citations

In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol.

1993 • 106 citations

Intravenous microdialysis sampling in awake, freely-moving rats

1992 • 104 citations

Quantitative assessment of blood-brain barrier damage during microdialysis.

1996 • 101 citations

Extracellular glutamate: on-line monitoring using microdialysis coupled to enzyme-amperometric analysis

1995 • 101 citations

Microdialysis sampling for determination of plasma protein binding of drugs.

1990 • 95 citations

Specific molecular mass detection of endogenously released neuropeptides using in vivo microdialysis/mass spectrometry

1995 • 92 citations

Dermal microdialysis sampling in vivo.

1994 • 90 citations

Concentration of Extracellular <scp>l</scp>-Glutamate Released from Cultured Nerve Cells Measured with a Small-Volume Online Sensor

1996 • 85 citations

Intracerebral Dialysis and the Blood‐Brain Barrier

1995 • 84 citations

Analysis of zidovudine distribution to specific regions in rabbit brain using microdialysis.

1992 • 74 citations

Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis

1996 • 72 citations

Evaluation of capillary electrophoresis with post-column derivatization and laser-induced fluorescence detection for the determination of substance P and its metabolites

1997 • 70 citations

Determination of tryptophan and kynurenine in brain microdialysis samples by capillary electrophoresis with electrochemical detection

1995 • 66 citations

Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline

1991 • 61 citations

Comparison of Plasma and Free Tissue Levels of Ceftriaxone in Rats by Microdialysis

1997 • 61 citations

Regional differences in the effect of the combined treatment of WAY 100635 and fluoxetine: an in vivo microdialysis study

1996 • 59 citations

Antipyrine as a dialyzable reference to correct differences in efficiency among and within sampling devices during in vivo microdialysis

1992 • 58 citations

Microdialysis assessment of microfibrous collagen containing a P-glycoprotein-mediated transport inhibitor, cyclosporine A, for local delivery of etoposide.

1996 • 58 citations

On-line coupling of in vivo microdialysis with capillary electrophoresis/electrochemistry

1999 • 56 citations

The use of microdialysis for the determination of plasma protein binding of drugs

1992 • 56 citations

On-line interface between microdialysis and capillary zone electrophoresis

1995 • 56 citations

Vitreous Disposition of Two Acycloguanosine Antivirals in the Albino and Pigmented Rabbit Models: A Novel Ocular Microdialysis Technique

1996 • 55 citations

Intravenous microdialysis in the mouse and the rat: development and pharmacokinetic application of a new probe.

1996 • 53 citations

Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470.

1996 • 52 citations

In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-Bearing rats

1996 • 52 citations

Brain, liver and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: a quantitative microdialysis study.

1995 • 52 citations

Microdialysis sampling in tumor and muscle: Study of the disposition of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (SR 4233)

1994 • 51 citations

Examination of microdialysis sampling in a well-characterized hydrodynamic system

1993 • 51 citations

Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.

1996 • 50 citations

Potential use of microdialysis in pharmacokinetics: a protein binding study.

1992 • 50 citations

Factors That Influence Microdialysis Recovery. Comparison of Experimental and Theoretical Microdialysis Recoveries in Rat Liver

1997 • 48 citations

Online coupling of in vivo microdialysis with tandem mass spectrometry

1992 • 47 citations

Microdialysis sampling coupled on-line to microseparation techniques

1997 • 46 citations

Monitoring of enzymatic hydrolysis of ivory nut mannan using on-line microdialysis sampling and anion-exchange chromatography with integrated pulsed electrochemical detection

1995 • 45 citations

Determination of Free Extracellular Concentrations of Piperacillin by Microdialysis

1996 • 45 citations

Dopamine D2-receptors regulate neurotensin release from nucleus accumbens and striatum as measured by in vivo microdialysis

1996 • 44 citations

Microdialysis sampling for hepatic metabolism studies. Impact of microdialysis probe design and implantation technique on liver tissue.

1995 • 41 citations

A microdialysis fibre based sampler for flow injection analysis: determination of L-lactate in biofluids by an electrochemically synthesised bilayer membrane based biosensor

1996 • 41 citations

Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism

1996 • 41 citations

4-trimethylammonium antipyrine: A quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis

1992 • 38 citations

The binding of cyclosporin A to human plasma: an in vitro microdialysis study.

1996 • 38 citations

Liquid chromatographic determination of tacrine and its metabolites in rat bile microdialysates

1994 • 38 citations

Continuous Monitoring of Blood-Brain Barrier Opening to Cr51-EDTA by Microdialysis Following Probe Injury

1990 • 38 citations

Influence of Estrogenic Status on the Lipolytic Activity of Parametrial Adipose Tissue in Vivo: an in Situ Microdialysis Study*

1997 • 36 citations

SPLANCHNIC HOMEOSTATIS DURING ENDOTOXIN CHALLENGE IN THE PIG AS ASSESSED BY MICRODIALYSIS AND TONOMETRY

1996 • 35 citations

On‐line amperometric assay of glucose, <scp>L</scp>‐glutamate, and acetylcholine using microdialysis probes and immobilized enzyme reactors

1995 • 34 citations

In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique

1993 • 32 citations

Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis.

1994 • 32 citations

On-line Microdialysis Desalting for Electrospray Ionization-Mass Spectrometry of Proteins and Peptides

1996 • 31 citations

On-line quantitation of enzymatic mannan hydrolysates in small-volume bioreactors by microdialysis sampling and column liquid chromatography-integrated pulsed electrochemical detection

1996 • 31 citations

Concentration-dependent plasma protein binding of flurbiprofen in the rat: an in vivo microdialysis study.

1996 • 30 citations

Topics in Xenobiochemistry – Application of microdialysis techniques in pharmacokinetic studies

1996 • 29 citations

Microdialysis Sampling for Pharmacological Studies: HPLC and CE Analysis

2021 • 29 citations

Evaluation of In-vivo Transdermal Absorption of Cyclosporin with Absorption Enhancer Using Intradermal Microdialysis in Rats

1996 • 29 citations

A new method of in-vivo microdialysis of the human brain

1995 • 28 citations

In vivo continuous monitoring of L-lactate coupling subcutaneous microdialysis and an electrochemical biocell

1995 • 28 citations

Automated analytical systems for drug development studies. II — A system for dissolution testing

1994 • 26 citations

In Vitro Optimisation of a Microdialysis System With Potential for On-line Monitoring of Lactate and Glucose in Biological Samples

1997 • 24 citations

Ischemia/Reperfusion Alters Uric Acid and Ascorbic Acid Levels in Liver

1996 • 24 citations

Glucose-induced decrease in glutamate levels in ischemic human brain by in-vivo microdialysis

1996 • 24 citations

On-line glucose monitoring by using microdialysis sampling and amperometric detection based on ?wired? glucose oxidase in carbon paste

1995 • 23 citations

Automated analytical systems for drug development studies 3. Multivessel dissolution testing system based on microdialysis sampling

1995 • 22 citations

Determination of kynurenic acid by capillary electrophoresis with laser-induced fluorescence detection

1997 • 22 citations

Microdialysis of adipose tissue during surgery: effect of local alpha- and beta-adrenoceptor blockade on blood flow and lipolysis.

1996 • 22 citations

Determination of extracellular methotrexate tissue levels by microdialysis in a rat model

1996 • 21 citations

Pharmaceutical and Biomedical Applications of Liquid Chromatography

1994 • 20 citations

Pharmacokinetics of different doses of methotrexate at steady state by in situ microdialysis in a rat model

1995 • 19 citations

Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes

1997 • 18 citations

Automated analytical systems for drug development studies part IV. A microdialysis system to study the partitioning of lomefloxacin across an erythrocyte membrane in vitro

1995 • 17 citations

Use of Intrauterine Microdialysis to Investigate Methanol-Induced Alterations in Uteroplacental Blood Flow

1996 • 17 citations

Aluminum chelation by 3-hydroxypyridin-4-ones in the rat demonstrated by microdialysis

1996 • 16 citations

Theophylline kinetics in peripheral tissues in vivo in humans

1995 • 16 citations

A Microdialysis Probe Coupled with A Miniaturized Thermal Glucose Sensor for In Vivo Monitoring

1995 • 14 citations

Simultaneous in Vivo Microdialysis in Plasma and Skeletal Muscle: A Study of the Pharmacokinetic Properties of Levodopa by Noncompartmental Analysis

1994 • 14 citations

Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog.

1995 • 14 citations

Automated analytical systems for drug development studies. V. A system for enzyme kinetic studies

1996 • 13 citations

Microdialysis sampling and high performance liquid chromatography with amperometric detection for sugar analysis in milk products

1996 • 13 citations

Effect of Daily Voluntary Running onIn VivoInsulin Action in Rat Skeletal Muscle and Adipose Tissue as Determined by the Microdialysis Technique

1995 • 13 citations

An intravascular microdialysis sampling system suitable for application in continuous biochemical monitoring of glucose and lactate

1996 • 12 citations

In Vivo Microdialysis for Pharmacokinetic Investigations: A Plasma Protein Binding Study of Valproate in Rabbits.

1994 • 12 citations

Dose-dependent delivery of colchicine to the rat hippocampus by microdialysis

1996 • 11 citations

In VivoHydroxylation of the Neurotoxin, 1-Methyl-4-phenylpyridinium, and the Effect of Monoamine Oxidase Inhibitors: Electrospray-MS Analysis of Intra-striatal Microdialysates

1996 • 9 citations

Effect of daily voluntary running on in vivo insulin action in rat skeletal muscle and adipose tissue as determined by the microdialysis technique

1995 • 9 citations

In vivo Microdialysis to Determine the Relative Pharmacokinetics of Drugs.

1996 • 9 citations

Alterations in methotrexate pharmacokinetics by naproxen in the rat as measured by microdialysis

1997 • 8 citations

High-performance liquid chromatographic analysis of (S)-α-amino-5-phosphonomethyl[1,1′-biphenyl]-3-propanoic acid (EAB 515) in brain and blood microdialysate (on-line) and in plasma ultrafiltrate of freely moving rats

1996 • 7 citations

On-Line Microdialysis Sampling

1994 • 4 citations

Measurement of free concentration of SDZ ICM 567 in blood and muscle using microdialysis sampling

1995 • 4 citations