Microdialysis sampling in tumor and muscle: Study of the disposition of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (SR 4233)

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors.

1990 • 184 citations

Microdialysis calibration using retrodialysis and zero-net flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus.

1993 • 175 citations

Sampling living systems using microdialysis probes

1991 • 151 citations

Drug distribution studies with microdialysis III: Extracellular concentration of caffeine in adipose tissue in man

1991 • 124 citations

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

1981 • 110 citations

In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol.

1993 • 106 citations

Intravenous microdialysis sampling in awake, freely-moving rats

1992 • 104 citations

The effect of hypoxia on the growth and radiation response of mammalian cells in culture

1974 • 101 citations

Therapeutic Advantage of Hypoxic Cells in Tumors: A Theoretical Study

1991 • 91 citations

The comparative enzymology and cell origin of rat hepatomas. I. Deoxycytidylate deaminase and thymine degradation.

1960 • 72 citations

Enzymology of the reductive bioactivation of SR 4233

1990 • 69 citations

Muscle Microdialysis as a Model Study to Relate the Drug Concentration in Tissue Interstitial Fluid and Dialysate.

1991 • 50 citations

In vivo microdialysis sampling coupled to liquid chromatography for the study of acetaminophen metabolism

1990 • 46 citations

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.

1993 • 33 citations

Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: Pharmacology and activity in vitro and in vivo

1992 • 26 citations

Microdialysis-perfusion sampling for the investigation of phenol metabolism

1989 • 20 citations

Effect of isoflurane anesthesia on antipyrine pharmacokinetics in the rat.

1992 • 3 citations