Architecture of P2Y Nucleotide Receptors: Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2003 • 2,754 citations

SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments

1995 • 1,763 citations

NPS@: Network Protein Sequence Analysis

2000 • 1,666 citations

Stereochemical quality of protein structure coordinates

1992 • 1,503 citations

[32] GOR method for predicting protein secondary structure from amino acid sequence

1996 • 1,239 citations

Department of Computer Science

1993 • 1,162 citations

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

2004 • 813 citations

Derivation of class II force fields. I. Methodology and quantum force field for the alkyl functional group and alkane molecules

1994 • 785 citations

The G protein-coupled receptor repertoires of human and mouse

2003 • 747 citations

Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

2002 • 662 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

2001 • 598 citations

How the protease thrombin talks to cells

1999 • 574 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid

2003 • 523 citations

Molecular dynamics simulation of a bilayer of 200 lipids in the gel and in the liquid crystal phase

1993 • 473 citations

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

2001 • 442 citations

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

2003 • 412 citations

Aquaporin-0 membrane junctions reveal the structure of a closed water pore

2004 • 382 citations

Purine and Pyrimidine (P2) Receptors as Drug Targets

2002 • 338 citations

A G Protein-coupled Receptor for UDP-glucose

2000 • 338 citations

Role of the conserved NPxxY(x) _5,6 F motif in the rhodopsin ground state and during activation

2003 • 337 citations

An algorithm for secondary structure determination in proteins based on sequence similarity

1986 • 305 citations

Derivation of rules for comparative protein modeling from a database of protein structure alignments

1994 • 288 citations

Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1

1984 • 263 citations

Improved performance in protein secondary structure prediction by inhomogeneous score combination.

1999 • 224 citations

The FROG PC series: programs for electron-density and model investigations for proteins

1993 • 213 citations

Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

2003 • 210 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

Molecular bases of defective signal transduction in the platelet P2Y ₁₂ receptor of a patient with congenital bleeding

2003 • 189 citations

Molecular architecture of G protein-coupled receptors

1996 • 178 citations

225th ACS National Meeting

2003 • 141 citations

Human P2Y₁ Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites

1998 • 141 citations

Structural Determinants of A₃ Adenosine Receptor Activation: Nucleoside Ligands at the Agonist/Antagonist Boundary

2002 • 136 citations

Macromolecular interactions: tracing the roots

2000 • 136 citations

The Role of Amino Acids in Extracellular Loops of the Human P2Y1 Receptor in Surface Expression and Activation Processes

1999 • 135 citations

Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y₁ Receptor Ligands

2000 • 125 citations

Role of the Extracellular Loops of G Protein-Coupled Receptors in Ligand Recognition: A Molecular Modeling Study of the Human P2Y₁ Receptor

1999 • 124 citations

A Mutational Analysis of Residues Essential for Ligand Recognition at the Human P2Y₁Receptor

1997 • 123 citations

Studies on the Structure of the G-Protein-Coupled Receptor Rhodopsin Including the Putative G-Protein Binding Site in Unactivated and Activated Forms

2001 • 94 citations

Quantitation of the P2Y₁Receptor with a High Affinity Radiolabeled Antagonist

2002 • 85 citations

Characterization of a Ca²⁺ Response to Both UTP and ATP at Human P2Y₁₁ Receptors: Evidence for Agonist-Specific Signaling

2003 • 83 citations

Modelling the P2Y purinoceptor using rhodopsin as template.

1995 • 76 citations

Acyclic and Cyclopropyl Analogues of Adenosine Bisphosphate Antagonists of the P2Y₁ Receptor: Structure−Activity Relationships and Receptor Docking

2001 • 69 citations

2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior

2002 • 31 citations

Evidence for the recognition of non‐nucleotide antagonists within the transmembrane domains of the human P2Y₁ receptor

2002 • 28 citations

Using genome-wide mapping in the mouse to identify genes that influence drug response

2003 • 18 citations