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Chemokines and leukocyte traffic

1998 • 2,755 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Human Chemokines: An Update

1997 • 2,235 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Chemokines

1997 • 1,926 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3

1998 • 857 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 • 722 citations

Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.

1992 • 683 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

Structure and Chromosomal Localization of the Human Stromal Cell-Derived Factor 1 (SDF1) Gene

1995 • 629 citations

A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells

1997 • 532 citations

Human Macrophage–derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells

1997 • 486 citations

Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells

1998 • 479 citations

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

1990 • 470 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Platelet factor 4 is chemotactic for neutrophils and monocytes.

1981 • 444 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3

1996 • 412 citations

Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7

1997 • 405 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

1992 • 365 citations

Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.

1995 • 351 citations

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

1999 • 348 citations

Chemokine receptors: Structure, function and role in microbial pathogenesis

1996 • 329 citations

Monocyte Chemoattractant Protein-1

1999 • 328 citations

Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.

1997 • 318 citations

Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3.

1996 • 314 citations

Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector

1996 • 304 citations

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

1990 • 302 citations

TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development

1997 • 292 citations

Identification of three related human GRO genes encoding cytokine functions.

1990 • 287 citations

B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement

1998 • 276 citations

Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1

1997 • 276 citations

Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability

1995 • 274 citations

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.

1993 • 273 citations

Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13

1997 • 260 citations

Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response

1996 • 260 citations

A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.

1997 • 256 citations

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

1998 • 249 citations

Molecular and Functional Characterization of Two Novel Human C-C Chemokines as Inhibitors of Two Distinct Classes of Myeloid Progenitors

1997 • 239 citations

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells

1990 • 236 citations

Molecular cloning and functional characterization of human lymphotactin.

1995 • 223 citations

Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression

1997 • 208 citations

The α-Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion

1998 • 206 citations

Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung.

1995 • 204 citations

Novel lymphocyte-specific CC chemokines and their receptors

1997 • 199 citations

The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia

1998 • 195 citations

Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac−/− Mice

1998 • 181 citations

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

1992 • 178 citations

Cloning and Characterization of Exodus, a Novel β-Chemokine

1997 • 176 citations

Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines

1998 • 169 citations

Eotaxin: Cloning of an Eosinophil Chemoattractant Cytokine and Increased mRNA Expression in Allergen-Challenged Guinea-Pig Lungs

1994 • 156 citations

Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease

1997 • 153 citations

Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages

1994 • 152 citations

Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells

1998 • 151 citations

Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide.

1989 • 147 citations

Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.

1997 • 142 citations

HCC-1, a novel chemokine from human plasma.

1996 • 136 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 136 citations

The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease

1997 • 129 citations

Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue.

1996 • 124 citations

Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3.

1997 • 123 citations

A cDNA Clone Used to Study mRNA Inducible in Human Tonsillar Lymphocytes by a Tumor Promoter1

1986 • 122 citations

Chemokine regulation of human megakaryocytopoiesis

1995 • 119 citations

Structures of human genes coding for cytokine LD78 and their expression.

1990 • 118 citations

Mobilization of early hematopoietic progenitor cells with BB-10010: a genetically engineered variant of human macrophage inflammatory protein- 1 alpha

1995 • 117 citations

Platelet factor 4 inhibits human megakaryocytopoiesis in vitro

1990 • 115 citations

CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.

1998 • 115 citations

Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells.

1989 • 114 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 114 citations

A novel polypeptide secreted by activated human T lymphocytes.

1989 • 112 citations

Effects of CC, CXC, C, and CX₃C Chemokines on Proliferation of Myeloid Progenitor Cells, and Insights into SDF‐1‐Induced Chemotaxis of Progenitors^a

1999 • 110 citations

Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2.

1996 • 110 citations

Human interferon-inducible protein 10: expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors.

1993 • 107 citations

Human Dermal Fibroblasts Express Eotaxin: Molecular Cloning, mRNA Expression, and Identification of Eotaxin Sequence Variants

1996 • 105 citations

Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage

1997 • 102 citations

Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes

1997 • 102 citations

Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum.

1993 • 101 citations

CKβ-11/Macrophage Inflammatory Protein-3β/EBI1-Ligand Chemokine Is an Efficacious Chemoattractant for T and B Cells

1998 • 101 citations

Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis

1997 • 101 citations

Dominant Myelopoietic Effector Functions Mediated by Chemokine Receptor CCR1

1999 • 98 citations

HCC-2, a human chemokine: Gene structure, expression pattern, and biological activity

1998 • 96 citations

Molecular cloning of a novel C or γ type chemokine, SCM‐1

1995 • 92 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 92 citations

Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth

1994 • 91 citations

Identification, cloning, and characterization of an immune activation gene.

1988 • 88 citations

Platelet Factor 4 and Other CXC Chemokines Support the Survival of Normal Hematopoietic Cells and Reduce the Chemosensitivity of Cells to Cytotoxic Agents

1997 • 87 citations

Cloning of ATAC, an activation‐induced, chemokine‐related molecule exclusively expressed in CD8+ T lymphocytes

1995 • 84 citations

Differential effects of the hematopoietic inhibitors MIP-1 alpha, TGF-beta, and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver.

1995 • 83 citations

Myelosuppressive effects in vivo of purified recombinant murine macrophage inflammatory protein-1 alpha.

1992 • 80 citations

Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes.

1991 • 76 citations

MCP-1, not MIP-1α, Is the Endogenous Chemokine That Cooperates With TGF-β to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures

1998 • 75 citations

SLC/Exodus2/6Ckine/TCA4 induces chemotaxis of hematopoietic progenitor cells: differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis vs. suppression of progenitor proliferation

1999 • 74 citations

Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth.

1991 • 71 citations

BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties

1995 • 71 citations

A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors.

1995 • 71 citations

Characterization of CKβ8 and CKβ8-1: Two Alternatively Spliced Forms of Human β-Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1

1998 • 70 citations

Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.

1993 • 68 citations

High Activity Suppression of Myeloid Progenitor Proliferation by Chimeric Mutants of Interleukin 8 and Platelet Factor 4

1995 • 68 citations

Characterization of CKβ8 and CKβ8-1: Two Alternatively Spliced Forms of Human β-Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1

1998 • 67 citations

Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice

1995 • 67 citations

Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells.

1998 • 64 citations

Cloning and expression of a γ-interferon-inducible gene in monocytes: a new member of a cytokine gene family

1989 • 64 citations

Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2

1999 • 63 citations

Characterization of a Novel CC Chemokine, HCC-4, Whose Expression Is Increased by Interleukin-10

1998 • 61 citations

Macrophage-Inflammatory Protein-3β/EBI1-Ligand Chemokine/CKβ-11, a CC Chemokine, Is a Chemoattractant with a Specificity for Macrophage Progenitors Among Myeloid Progenitor Cells

1998 • 59 citations

Eotaxin Modulates Myelopoiesis and Mast Cell Development From Embryonic Hematopoietic Progenitors

1998 • 57 citations

A New Year Greeting From a New Editor

1998 • 57 citations

Selective induction of the beta chemokine C10 by IL-4 in mouse macrophages.

1994 • 56 citations

Bovine granulocyte chemotactic protein-2 is secreted by the endometrium in response to interferon-tau (IFN-τ)

1997 • 56 citations

Myelosuppressive effects in vivo with very low dosages of monomeric recombinant murine macrophage inflammatory protein-1 alpha.

1994 • 55 citations

Mast cells produce ENA-78, which can function as a potent neutrophil chemoattractant during allergic airway inflammation

1998 • 55 citations

Induction of synthesis and release of interleukin‐8 from human articular chondrocytes and cartilage explants

1992 • 54 citations

CKβ8, a novel CC chemokine that predominantly acts on monocytes

1997 • 53 citations

Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer.

1993 • 50 citations

Ex Vivo Culture of CD34+/Lin−/DR− Cells in Stroma-Derived Soluble Factors, Interleukin-3, and Macrophage Inflammatory Protein-1α Maintains Not Only Myeloid But Also Lymphoid Progenitors in a Novel Switch Culture Assay

1998 • 50 citations

Activation of the Megakaryocyte-specific Gene Platelet Basic Protein (PBP) by the Ets Family Factor PU.1

1997 • 49 citations

Isolation and Characterization of LMC, a Novel Lymphocyte and Monocyte Chemoattractant Human CC Chemokine, with Myelosuppressive Activity

1998 • 48 citations

Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.

1997 • 48 citations

Biological and structural properties of MIP-1$alpha; expressed in yeast

1992 • 47 citations

Myeloid Progenitor Cell Proliferation and Mobilization Effects of BB10010, a Genetically Engineered Variant of Human Macrophage Inflammatory Protein-1α, in a Phase I Clinical Trial in Patients with Relapsed/Refractory Breast Cancer

1998 • 46 citations

Steel Factor Enhances Integrin-Mediated Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK) and Paxillin

1997 • 44 citations

Regulation of I‐309 gene expression in human monocytes by endogenous interleukin‐1

1997 • 42 citations

CD34+/CD33- cells reselected from macrophage inflammatory protein 1 alpha+interleukin-3--supplemented "stroma-noncontact" cultures are highly enriched for long-term bone marrow culture initiating cells

1994 • 41 citations

Characterization of GRO α, β and γ expression in human colonic tumours: potential significance of cytokine involvement

1992 • 40 citations

H-Ras Is Involved in the Inside-out Signaling Pathway of Interleukin-3–Induced Integrin Activation

1999 • 37 citations

CXC Chemokines Suppress Proliferation of Myeloid Progenitor Cells by Activation of the CXC Chemokine Receptor 2

1998 • 36 citations

Signal Sequence Trap: Expression Cloning Method for Secreted Proteins and Type 1 Membrane Proteins

2003 • 35 citations

Purification and Biochemical Characterisation of Human and Murine Stem Cell Inhibitors (SCI)

1992 • 33 citations

Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family

1996 • 32 citations

Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC

1998 • 32 citations

A Randomized Phase-II Study of BB-10010 (Macrophage Inflammatory Protein- 1) in Patients With Advanced Breast Cancer Receiving 5-Fluorouracil, Adriamycin, and Cyclophosphamide Chemotherapy

1998 • 28 citations

Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.

1995 • 26 citations

Suppressive effects of recombinant human monokine induced by IFN-gamma (rHuMig) chemokine on the number of committed and primitive hemopoietic progenitors in liquid cultures of CD34+ human bone marrow cells.

1997 • 26 citations

Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells

1997 • 26 citations

GRO: A Novel Chemotactic Cytokine

1991 • 23 citations

Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1α (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010

1998 • 17 citations

Cell type specific expression of members of the IL-8/NAP-1 gene family

1993 • 17 citations

A randomized phase II study of BB‐10010: a variant of human macrophage inflammatory protein‐1α for patients receiving high‐dose etoposide and cyclophosphamide for malignant lymphoma and breast cancer

1997 • 14 citations

Mob-1 expression in IL-2-induced ARDS: regulation by TNF-alpha

1995 • 14 citations

mob-1 EXPRESSION IN IL-2-INDUCED ARDS.

1996 • 1 citations