Molecular basis for sequence-specific DNA alkylation by CC-1065

Design of Sequence-Specific DNA-Binding Molecules

1986 • 840 citations

The molecular origin of DNA-drug specificity in netropsin and distamycin.

1985 • 800 citations

Structure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution

1986 • 492 citations

CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.

1978 • 267 citations

On the source of intramolecular and enzymatic reactivity

1985 • 266 citations

DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards

1986 • 233 citations

Interactions between functional groups in protein-nucleic acid associations

1982 • 218 citations

DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting

1984 • 205 citations

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1985 • 202 citations

Reaction of the Antitumor Antibiotic CC-1065 with DNA: Structure of a DNA Adduct with DNA Sequence Specificity

1984 • 200 citations

Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity

1986 • 188 citations

Origins of netropsin binding affinity and specificity: correlations of thermodynamic and structural data.

1987 • 185 citations

Methidiumpropyl-EDTA-Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA

1983 • 175 citations

Preliminary toxicity studies with the DNA-binding antibiotic, CC-1065.

1984 • 144 citations

CC-1065(NSC 298223), a potent new antitumor agent. Improved production and isolation, characterization and antitumor activity.

1981 • 137 citations

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

1988 • 129 citations

Covalent binding of antitumor antibiotics in the minor groove of DNA. Mechanism of action of CC-1065 and the pyrrolo(1,4)benzodiazepines

1986 • 124 citations

Sequence specificity in aflatoxin B1--DNA interactions.

1983 • 121 citations

The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.

1986 • 116 citations

Some Pertinent Aspects of Mechanism as Determined with Small Molecules

1976 • 99 citations

Structure of CC-1065 (NSC-298223), a new antitumor antibiotic.

1980 • 94 citations

DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

1986 • 94 citations

CC-1065 (NSC 298223), a most potent antitumor agent: kinetics of inhibition of growth, DNA synthesis, and cell survival.

1982 • 80 citations

Total synthesis of U- 71,184, s potent new antitumor agent modeled on cc-1065

1986 • 47 citations

Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogs

1987 • 45 citations

Binding of CC‐1065 to poly‐ and oligonucleotides

1985 • 36 citations

Antitumor activity and biochemistry of novel analogs of the antibiotic, CC-1065

1986 • 35 citations

Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1.

1987 • 32 citations

Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin

1985 • 31 citations

Structure and activity relationship of several novel CC-1065 analogs

1987 • 30 citations

A Theoretical Investigation of the Sequence Specificity in the Binding of the Antitumor Drug Anthramycin to DNA

1986 • 22 citations

Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment

1986 • 18 citations

Bis-des-hydroxy, bis-des-methoxy cc-1065. Synthesis, DNA binding, andbiological activity.

1988 • 16 citations

A circular dichroism study of the binding of CC-1065 to B and Z form poly(dl-5BrdC)·poly(dl-5BrdC)

1987 • 14 citations