Genetic Variations in Esophageal Cancer Risk and Prognosis

Population Attributable Risks of Esophageal and Gastric Cancers

2003 • 768 citations

Incidence of Adenocarcinoma of the Esophagus Among White Americans by Sex, Stage, and Age

2008 • 683 citations

A Prospective Study of Tobacco, Alcohol, and the Risk of Esophageal and Gastric Cancer Subtypes

2007 • 406 citations

The Incidence of Esophageal Cancer and High-Grade Dysplasia in Barrett's Esophagus: A Systematic Review and Meta-Analysis

2008 • 401 citations

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm

2007 • 347 citations

Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines.

2003 • 313 citations

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States).

2001 • 306 citations

Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics

2001 • 259 citations

Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver

2008 • 240 citations

Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer

2007 • 238 citations

Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer

2005 • 231 citations

Alcohol, ALDH2, and Esophageal Cancer: A Meta-analysis Which Illustrates the Potentials and Limitations of a Mendelian Randomization Approach

2005 • 225 citations

Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.

2001 • 223 citations

Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma

2004 • 220 citations

TP53 family members and human cancers

2003 • 210 citations

Genetic polymorphisms and esophageal cancer risk

2007 • 208 citations

Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis

2008 • 205 citations

Polymorphisms of Death Pathway Genes FAS and FASL in Esophageal Squamous-Cell Carcinoma

2004 • 199 citations

Population Substructure and Control Selection in Genome-Wide Association Studies

2008 • 199 citations

Functional Haplotypes in the Promoter of Matrix Metalloproteinase-2 Predict Risk of the Occurrence and Metastasis of Esophageal Cancer

2004 • 195 citations

Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: A meta-analysis

2006 • 183 citations

The Role ofP53andMDM2Polymorphisms in the Risk of Esophageal Squamous Cell Carcinoma

2005 • 177 citations

Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: Current and developing technologies

2008 • 174 citations

SNP-SNP interactions in breast cancer susceptibility

2006 • 170 citations

Genetic Variations in Radiation and Chemotherapy Drug Action Pathways Predict Clinical Outcomes in Esophageal Cancer

2006 • 170 citations

Chemoradiation in the Management of Esophageal Cancer

2007 • 166 citations

Pharmacogenetics for individualized cancer chemotherapy

2005 • 159 citations

Ser326Cys polymorphism inhOGG1 gene and risk of esophageal cancer in a Chinese population

2001 • 153 citations

Nucleotide Excision Repair Pathways Involved in Cisplatin Resistance in Non-Small-Cell Lung Cancer

2003 • 150 citations

Cancer genomics and genetics of FGFR2 (Review)

1992 • 148 citations

Cancer Pharmacogenomics: Powerful Tools in Cancer Chemotherapy and Drug Development

2005 • 129 citations

Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.

1999 • 128 citations

Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer

2001 • 127 citations

Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China.

2003 • 124 citations

Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population

2002 • 122 citations

The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma

2005 • 122 citations

Pharmacogenetics in Cancer Treatment

2003 • 118 citations

Genetic Polymorphisms of Tobacco- and Alcohol-Related Metabolizing Enzymes and Human Esophageal Squamous Cell Carcinoma Susceptibility

1997 • 118 citations

Single nucleotide polymorphism array analysis of cancer

2006 • 117 citations

Familiality in Barrett's Esophagus, Adenocarcinoma of the Esophagus, and Adenocarcinoma of the Gastroesophageal Junction

2006 • 116 citations

Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid

2007 • 112 citations

Genome-Wide Association Study in Esophageal Cancer Using GeneChip Mapping 10K Array

2005 • 111 citations

Elevated tumour interleukin-1β is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer

2006 • 105 citations

GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: Different pattern of squamous cell carcinoma and adenocarcinoma

2004 • 102 citations

Genetic polymorphisms ofp53 andGSTP1,but notNAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus

2000 • 101 citations

Dietary Patterns and Risk of Squamous-Cell Carcinoma and Adenocarcinoma of the Esophagus and Adenocarcinoma of the Gastric Cardia: A Population-Based Case-Control Study in Sweden

2006 • 96 citations

Gene-environment interaction in tobacco-related cancers

2008 • 92 citations

Environmental exposures and gene regulation in disease etiology

2008 • 91 citations

Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population

2003 • 90 citations

The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer.

2001 • 90 citations

Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks

2006 • 89 citations

A Functional Epidermal Growth Factor (EGF) Polymorphism, EGF Serum Levels, and Esophageal Adenocarcinoma Risk and Outcome

2008 • 89 citations

Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran

2006 • 86 citations

Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma

2005 • 83 citations

Sporadic colorectal cancer and individual susceptibility: A review of the association studies investigating the role of DNA repair genetic polymorphisms

2007 • 83 citations

CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus

1997 • 82 citations

LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China

2005 • 82 citations

Microarray Technology and Applications in the Arena of Genome-Wide Association

2008 • 81 citations

Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk

2008 • 79 citations

Incidence of esophageal and gastric cancers among Hispanics, non-Hispanic whites and non-Hispanic blacks in the United States: subsite and histology differences

2007 • 78 citations

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in Esophageal Squamous Cell Carcinoma

2008 • 78 citations

Genotyping of theCYP1A1 andGSTM1 genes in esophageal carcinoma patients with special reference to smoking

1997 • 77 citations

The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden

2006 • 76 citations

GSTT1, GSTM1 and GSTP1 genetic polymorphisms and interaction with tobacco, alcohol and occupational exposure in esophageal cancer patients from North India

2005 • 73 citations

Approaches and Resources for Prediction of the Effects of Non-Synonymous Single Nucleotide Polymorphism on Protein Function and Interactions

2008 • 73 citations

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma

2008 • 71 citations

The Application of Single Nucleotide Polymorphism Microarrays in Cancer Research

2007 • 70 citations

Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population

2005 • 67 citations

SULT1A1 polymorphism and esophageal cancer in males

2002 • 67 citations

A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma

2001 • 66 citations

Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk

2008 • 66 citations

Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males

2008 • 65 citations

CYP3A5 genotypes and risk of oesophageal cancer in two South African populations

2004 • 64 citations

Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma

2003 • 63 citations

Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer

2004 • 63 citations

Survival Trends in Patients With Gastric and Esophageal Adenocarcinomas: A Population-Based Study

2008 • 60 citations

Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma

2005 • 60 citations

A Single Nucleotide Polymorphism in the 5′ Untranslated Region of the <i>EGF</i> Gene Is Associated with Occurrence and Malignant Progression of Gastric Cancer

2005 • 60 citations

Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer

2005 • 60 citations

Contribution of p53, p63, and p73 to the developmental diseases and cancer.

2008 • 59 citations

Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma

2006 • 58 citations

A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma

2007 • 55 citations

XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk

2007 • 53 citations

Incidence of esophageal and gastric carcinomas among American Asians/Pacific Islanders, whites, and blacks

2005 • 52 citations

Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males

2005 • 50 citations

Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa

2003 • 50 citations

The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma

2005 • 48 citations

Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma

2004 • 47 citations

Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract

2005 • 46 citations

Genetic Variation in Genes for the Xenobiotic-Metabolizing EnzymesCYP1A1, EPHX1, GSTM1, GSTT1, andGSTP1and Susceptibility to Colorectal Cancer in Lynch Syndrome

2008 • 46 citations

Association of GSTP1 Polymorphism and Survival for Esophageal Cancer

2005 • 45 citations

Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status

2005 • 44 citations

Role of GSTM3 Polymorphism in the Risk of Developing Esophageal Cancer

2007 • 42 citations

Polymorphisms of the DNA repair gene xeroderma pigmentosum groups A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China

2007 • 42 citations

Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population

2004 • 42 citations

Association of the Polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with Risk for Esophageal Squamous Cell Dysplasia and Carcinoma

2008 • 36 citations

Familial Risk for Esophageal Cancer: An Updated Epidemiologic Study From Sweden

2006 • 34 citations

Favorable Genetic Polymorphisms Predictive of Clinical Outcome of Chemoradiotherapy for Stage II/III Esophageal Squamous Cell Carcinoma in Japanese

2007 • 32 citations

Association between p21 codon 31 polymorphism and esophageal cancer risk in a Taiwanese population

2003 • 31 citations

Association of Matrix Metalloproteinases-9 Gene Polymorphisms with Genetic Susceptibility to Esophageal Squamous Cell Carcinoma

2008 • 30 citations

Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 ( ECRG1 ) and its related risk to esophageal squamous cell carcinoma

2005 • 27 citations

Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China

2003 • 27 citations

Short tandem repeat polymorphism in a novel esophageal cancer‐related gene (ECRG2) implicates susceptibility to esophageal cancer in Chinese population

2003 • 26 citations

G>C SNP of Thymidylate Synthase with Respect to Colorectal Cancer

2007 • 26 citations

Loss of Heterozygosity in Endometrial Carcinoma

2008 • 25 citations

Evidence for a familial esophageal cancer susceptibility gene on chromosome 13.

2003 • 23 citations

Polymorphisms of short tandem repeat of genes and breast cancer susceptibility

2007 • 23 citations

The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: Interaction between areca chewing and smoking

2005 • 21 citations

Replication of a genome‐wide case–control study of esophageal squamous cell carcinoma

2008 • 17 citations

Association Between the Length of a CA Dinucleotide Repeat in the EGFR and Risk of Breast Cancer

2008 • 16 citations

L‐myc Restriction Fragment Length Polymorphism in Japanese Patients with Esophageal Cancer

2000 • 15 citations

Interaction of <I>EGFR</I> 497Arg>Lys With <I>EGF</I> +61A>G Polymorphism: Modulation of Risk in Esophageal Cancer

2008 • 15 citations

[Correlations between serine hydroxymethyltransferase1 C1420T polymorphisms and susceptibilities to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].

2006 • 14 citations

Polymorphism at the 3′-UTR of the thymidylate synthase gene: A potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation

2005 • 12 citations

[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer].

2003 • 8 citations

[Polymorphism of NAD(P)H dehydrogenase (quinone) 1 (NQO1) C 609 T and risk of esophageal neoplasm].

2004 • 6 citations