Expression de protéines recombinantes dans le lait d'animaux transgéniques

Production of human α-interferon in silkworm using a baculovirus vector

1985 • 475 citations

High Level Expression of Active Human Alpha-1-Antitrypsin in the Milk of Transgenic Sheep

1991 • 349 citations

The Oligosaccharides of Glycoproteins: Bioprocess Factors Affecting Oligosaccharide Structure and their Effect on Glycoprotein Properties

1991 • 296 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

Genomic analysis of the major bovine milk protein genes

1990 • 287 citations

Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice

1987 • 273 citations

Transgenic Production of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Generation of Transgenic Goats and Analysis of Expression

1991 • 270 citations

Generation Of Transgenic Dairy Cattle Using ‘in vitro’ Embryo Production

1991 • 269 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

Environmental Effects on Protein Glycosylation

1990 • 246 citations

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.

1990 • 217 citations

Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk

1987 • 194 citations

Long range restriction analysis of the bovine casein genes

1990 • 192 citations

High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice.

1990 • 179 citations

A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.

1988 • 177 citations

Comparison of the whey acidic protein genra of the rat and mouse

1984 • 176 citations

Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep

1989 • 168 citations

High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C.

1992 • 163 citations

High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine.

1991 • 147 citations

Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

1991 • 143 citations

Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

1991 • 136 citations

Gene Transfer into Sheep

1988 • 136 citations

Production of Functional Human Hemoglobin in Transgenic Swine

1992 • 135 citations

The Safety of Foods Developed by Biotechnology

1992 • 133 citations

The rat casein multigene family. Fine structure and evolution of the beta-casein gene.

1985 • 127 citations

Comparison of the Regulation of the Whey Acidic Protein Gene with that of a Hybrid Gene Containing the Whey Acidic Protein Gene Promoter in Transgenic Mice

1988 • 121 citations

Rabbit β-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits

1990 • 120 citations

Position-independent expression of the ovine β-lactoglobulin gene in transgenic mice

1992 • 120 citations

Characterization of the gene encoding ovine beta-lactoglobulin

1988 • 116 citations

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci

1991 • 116 citations

Bovine AlphaS1-Casein Gene Sequences Direct High Level Expression of Active Human Urokinase in Mouse Milk

1990 • 106 citations

Transgenic Expression of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Purification and Characterization of the Recombinant Enzyme

1991 • 103 citations

Tissue-specific expression of the rat β-casein gene in transgenic mice

1988 • 102 citations

Genomic organisation of the bovine alpha-S1 casein gene

1991 • 100 citations

Organization and sequence of the human α-lactalbumin gene

1987 • 99 citations

Efficient tissue‐specific expression of bovine α‐lactalbumin in transgenic mice

1989 • 96 citations

Tissue-specific, high level expression of the rat whey acidic protien gene in transgenic mice

1990 • 84 citations

Making transgenic livestock: Genetic engineering on a large scale

1992 • 84 citations

A Mammary-Specific Promoter Directs Expression of Growth Hormone not only to the Mammary Gland, but also to Bergman Glia Cells in Transgenic Mice

1991 • 82 citations

High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.

1992 • 78 citations

Human Hemoglobin Switching

1991 • 76 citations

Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype

1991 • 71 citations

Lactogenic Hormone and Cell Type-Specific Control of the Whey Acidic Protein Gene Promoter in Transfected Mouse Cells

1991 • 65 citations

Glycoprotein pharmaceuticals: scientific and regulatory considerations, and the US Orphan Drug Act

1992 • 62 citations

Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.

1991 • 59 citations

Prolactin stimulates milk protein promoter in CHO cells cotransfected with prolactin receptor cDNA

1990 • 58 citations

Production of Cystic Fibrosis Transmembrane Conductance Regulator in the Milk of Transgenic Mice

1992 • 57 citations

Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells.

1990 • 55 citations

High expression of the caprine β‐casein gene in transgenic mice

1992 • 55 citations

Production of the mouse whey acidic protein in transgenic pigs during lactation

1991 • 54 citations

Expression of active recombinant human $alpha;1-antitrypsin in transgenic rabbits

1991 • 53 citations

Expression of the whey acidic protein in transgenic pigs impairs mammary development

1992 • 53 citations

Breast Cancer Protein PS2 Synthesis in Mammary Gland of Transgenic Mice and Secretion into Milk

1989 • 52 citations

A pregnancy-specific mammary nuclear factor involved in the repression of the mouse beta-casein gene transcription by progesterone.

1992 • 49 citations

Rabbit Whey Acidic Protein Concentration in Milk, Serum, Mammary Gland Extract, and Culture Medium

1991 • 48 citations

A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk

1992 • 46 citations

Expression analysis of ruminant α‐lactalbumin in transgenic mice: Developmental regulation and general location of important cis‐regulatory elements

1992 • 41 citations

Hormone responsive elements within the upstream sequences of the rabbit whey acidic protein (WAP) gene direct chloramphenicol acetyl transferase (CAT) reporter gene expression in transfected rabbit mammary cells

1991 • 38 citations

Expression of human growth hormone in the milk of transgenic mice

1991 • 38 citations

Structure of the gene encoding rabbit β-casein

1991 • 36 citations

Isolation of recombinant proteins from milk

1992 • 34 citations

Functional human CD4 protein produced in milk of transgenic mice.

1989 • 31 citations

Wolffish Antifreeze Protein from Transgenic Drosophila

1990 • 30 citations

Structure of the gene encoding rabbit

1992 • 27 citations

Induction of lactogenesis in transgenic virgin pigs: evidence for gene and integration site-specific hormonal regulation.

1992 • 27 citations

The prospects for domesticating milk protein genes

1992 • 27 citations

The bovine α‐lactalbumin promoter directs expression of ovine trophoblast interferon in the mammary gland of transgenic mice

1991 • 26 citations

Mammary development and milk secretion in transgenic mice expressing the sheep β-lactoglobulin gene

1992 • 26 citations

Prospects for the genetic engineering of milk

1992 • 26 citations

Complete sequence of the rabbit whey acidic protein gene

1990 • 25 citations

Gene expression in the mammary gland

1990 • 25 citations

Comparing the glycosylation patterns of recombinant glycoproteins

1992 • 24 citations

A distal region enhances the prolactin induced promoter activity of the rabbit αs1-casein gene

1992 • 16 citations

A Transfected α-Casein Minigene Bypasses Posttranscriptional Control by Hormones, but Retains Cell-Substratum Regulation in Mammary Epithelial Cells

1988 • 13 citations

Oncogene expression in mammary epithelial cells

1992 • 11 citations

Induction of lactogenesis in transgenic virgin pigs: evidence for gene and integration site-specific hormonal regulation

1992 • 11 citations

Production of human α₁‐antitrypsin in the milk of transgenic sheep and mice: Targeting expression of CDNA sequences to the mammary gland

1991 • 9 citations

Transgenics Primed for Research

1990 • 9 citations

Quantitative collection of milk and active recombinant proteins from the mammary glands of transgenic mice

1992 • 9 citations

Les animaux transgéniques

1998 • 6 citations

Transgenic Pharming Advances

1992 • 6 citations

Whole Animals for Wholesale Protein Production

1992 • 4 citations