Transgenic Expression of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Purification and Characterization of the Recombinant Enzyme

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection

1988 • 537 citations

Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.

1984 • 387 citations

Coronary Thrombolysis with Tissue-Type Plasminogen Activator in Patients with Evolving Myocardial Infarction

1984 • 362 citations

Tissue Plasminogen Activator: Chemical and Physiological Aspects

1984 • 210 citations

Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk

1987 • 194 citations

A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.

1988 • 177 citations

Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep

1989 • 168 citations

Purification and Characterization of a Melanoma Cell Plasminogen Activator

1983 • 155 citations

Use of N-glycanase to release asparagine-linked oligosaccharides for structural analysis

1987 • 138 citations

Quantitation of picomole levels of N-acetyl- and N-glycolylneuraminic acids by a HPLC-adaptation of the thiobarbituric acid assay

1986 • 85 citations

Analysis of glycoprotein-derived oligosaccharides by high-pH anion-exchange chromatography

1990 • 84 citations

Isolation of two variants of native one‐chain tissue plasminogen activator

1982 • 78 citations

Spontaneous fibrinolysis in whole human plasma. Identification of tissue activator-related protein as the major plasminogen activator causing spontaneous activity in vitro.

1985 • 73 citations

Large-scale purification of human tissue-type plasminogen activator using monoclonal antibodies

1985 • 59 citations

A Modified Human Tissue Plasminogen Activator with Extended Half–Life In Vivo

1987 • 55 citations

Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells

1989 • 45 citations

Characterization Studies of Human Tissue-type Plasminogen Activator Produced by Recombinant DNA Technology

1986 • 38 citations

On the Composition and Function of the Carbohydrate Moiety of Tissue-Type Plasminogen Activator from Human Melanoma Cells

1985 • 33 citations

Thrombolytic reperfusion of acute myocardial infarction: Resolved and unresolved issues

1988 • 31 citations

Fibrin-specific thrombolytic therapy

1988 • 10 citations