Neurogenetic Studies of Ion Channels in Drosophila

Diversity and ubiquity of K channels

1988 • 1,342 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

New insights into the behavior of muscle during active lengthening

1990 • 725 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus

1991 • 629 citations

The effect of temperature on the electrical activity of the giant axon of the squid

1949 • 555 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Molecular analysis of the para locus, a sodium channel gene in Drosophila

1989 • 501 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes

1990 • 461 citations

Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

1988 • 443 citations

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel

1987 • 412 citations

Identification of an Intracellular Peptide Segment Involved in Sodium Channel Inactivation

1988 • 382 citations

Morphological plasticity of motor axons in Drosophila mutants with altered excitability

1990 • 381 citations

A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus

1991 • 361 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

1989 • 351 citations

Genetic Dissection of Behavior

1973 • 327 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

K ⁺ Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse

1990 • 323 citations

THE BEHAVIOR OF FOUR NEUROLOGICAL MUTANTS OF DROSOPHILA

1969 • 306 citations

The maleless protein associates with the X chromosome to regulate dosage compensation in drosophila

1991 • 293 citations

Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel

1991 • 286 citations

Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade

1992 • 270 citations

1990: Annus Mirabilis of Potassium Channels

1991 • 261 citations

Two Mutations of synaptic transmission in Drosophila

1977 • 246 citations

Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.

1976 • 246 citations

Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila

1987 • 244 citations

A Drosophila mutation that eliminates a calcium-dependent potassium current.

1986 • 244 citations

Temperature-Sensitive Mutations in Drosophila melanogaster , VII. A Mutation ( para ^ts ) Causing Reversible Adult Paralysis

1971 • 234 citations

Genetic modification of potassium channels in Drosophila Shaker mutants

1981 • 225 citations

A-type potassium channels expressed from Shaker locus cDNA.

1988 • 225 citations

Genetic manipulation of ion channels: A new approach to structure and mechanism

1989 • 223 citations

Potassium Currents in Drosophila : Different Components Affected by Mutations of Two Genes

1983 • 201 citations

Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alteration of potassium currents in Shaker mutants

1985 • 194 citations

Control of X chromosome transcription by the maleless gene in Drosophila

1980 • 187 citations

Neurogenetic Analysis of Potassium Currents in Drosophila: Synergistic Effects on Neuromuscular Transmission in Double Mutants

1983 • 185 citations

Calcium Coordination and the Calmodulin Fold: Divergent versus Convergent Evolution

1987 • 184 citations

A Drosophila mutant with a temperature-sensitive block in nerve conduction.

1978 • 180 citations

Abnormal action potentials associated with the Shaker complex locus of Drosophila

1981 • 179 citations

Protein Kinase Activity Closely Associated with a Reconstituted Calcium-Activated Potassium Channel

1991 • 178 citations

Genetics of the nervous system inDrosophila

1982 • 178 citations

Modulation of ION Channels in Neurons and Other Cells

1988 • 176 citations

MALE-SPECIFIC LETHAL MUTATIONS OF DROSOPHILA MELANOGASTER

1980 • 175 citations

Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes

1988 • 174 citations

GENETICS OF ACETYLCHOLINESTERASE IN DROSOPHILA MELANOGASTER

1976 • 163 citations

Dissociated neurons from normal and mutant Drosophila larval central nervous system in cell culture

1983 • 161 citations

Single-Channel and Genetic Analyses Reveal Two Distinct A-Type Potassium Channels in Drosophila

1987 • 156 citations

Effects of transposable element insertions on RNA encoded by the white gene of Drosophila

1984 • 147 citations

Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster

1980 • 146 citations

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in shaker K+ channels

1991 • 145 citations

Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing.

1982 • 141 citations

Expression of ion channels and mutational effects in giant Drosophila neurons differentiated from cell division-arrested embryonic neuroblasts

1991 • 137 citations

Gene Dosage Compensation in Drosophila Melanogaster

1987 • 134 citations

Similarities in Amino Acid Sequences of Drosophila eag and Cyclic Nucleotide-Gated Channels

1991 • 133 citations

Sodium-activated potassium current in cultured avian neurones

1985 • 126 citations

Alteration of Four Identified K ⁺ Currents in Drosophila Muscle by Mutations in eag

1991 • 126 citations

Ionic currents of Drosophila neurons in embryonic cultures

1988 • 121 citations

Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster

1987 • 119 citations

napts, a Mutation affecting sodium channel activity in Drosophila, Is an allele of mle a regulator of X chromosome transcription

1991 • 119 citations

Complete separation of four potassium currents in drosophila

1989 • 107 citations

The role of the divergent amino and carboxyl domains on the inactivation properties of potassium channels derived from the Shaker gene of Drosophila

1990 • 104 citations

Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster

1984 • 104 citations

A Na+‐activated K+ current in cultured brain stem neurones from chicks.

1989 • 102 citations

NEUROGENETICS OF MEMBRANE EXCITABILITY IN DROSOPHILA

1986 • 101 citations

Two sodium-channel genes in Drosophila: implications for channel diversity.

1989 • 98 citations

Shaker K+ channel subunits form heteromultimeric channels with novel functional properties

1990 • 97 citations

The drosophila shaker gene codes for a distinctive K+ current in a subset of neurons

1990 • 92 citations

Voltage-gated potassium channels in larval CNS neurons of Drosophila

1988 • 90 citations

Single-channel analysis of four distinct classes of potassium channels in Drosophila muscle

1988 • 86 citations

Voltage-clamp analysis of sodium channels in wild-type and mutant Drosophila neurons

1988 • 84 citations

Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.

1990 • 79 citations

A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila

1990 • 78 citations

GENETIC STUDIES OF MEMBRANE EXCITABILITY IN DROSOPHILA: LETHAL INTERACTION BETWEEN TWO TEMPERATURE-SENSITIVE PARALYTIC MUTATIONS

1984 • 77 citations

A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.

1991 • 71 citations

Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability.

1990 • 70 citations

Properties of potassium currents and their role in membrane excitability inDrosophilalarval muscle fibers

1990 • 69 citations

Genetic and Voltage-clamp Analysis of a Drosophila Potassium Channel

1983 • 69 citations

The roles of potassium currents in Drosophila flight muscles

1988 • 65 citations

Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster.

1991 • 64 citations

The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster.

1989 • 63 citations

Giant Drosophila neurons differentiated from cytokinesis‐arrested embryonic neuroblasts

1990 • 60 citations

Families of potassium channel genes in mammals: Toward an understanding of the molecular basis of potassium channel diversity

1991 • 58 citations

Two distinct calcium-activated potassium currents in larval muscle fibres ofDrosophila melanogaster

1986 • 56 citations

Potentiation of a transient outward current by Na+ influx in crayfish neurones

1985 • 56 citations

Analysis of Repolarization of Presynaptic Motor Terminals in Drosophila Larvae Using Potassium-Channel-Blocking Drugs and Mutations

1992 • 55 citations

Gene dosage and complementation analysis of the Shaker locus in Drosophila

1987 • 54 citations

Genes and membrane excitability in Drosophila

1985 • 53 citations

Nerve Terminal Excitability and Neuromuscular Transmission inT(X;Y)V7andShakerMutants ofDrosophila Melanogaster

1991 • 52 citations

GENETIC APPROACH TO THE STUDY OF THE NERVOUS SYSTEM

1976 • 50 citations

Alterations in the expression and gating of drosophila sodium channels by mutations in the para gene

1989 • 50 citations

THE RESPONSE OF DOPA DECARBOXYLASE ACTIVITY TO VARIATIONS IN GENE DOSAGE IN DROSOPHILA: A POSSIBLE LOCATION OF THE STRUCTURAL GENE

1975 • 50 citations

Differentiation of embryonic Drosophila cells in vitro

1968 • 48 citations

Genetics and Molecular Biology of Ionic Channels in Drosophila

1986 • 48 citations

Mutational and gene dosage analysis of calcium-activated potassium channels in Drosophila: Correlation of micro- and macroscopic currents

1990 • 44 citations

Conduction in the Giant Nerve Fiber Pathway in Temperature-Sensitive Paralytic Mutants of Drosophila

1990 • 43 citations

Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus

1985 • 43 citations

Thetip-EMutation ofDrosophilaDecreases Saxitoxin Binding and Interacts with Other Mutations Affecting Nerve Membrane Excitability

1986 • 41 citations

Ion Channels in Drosophila

1988 • 41 citations

Occult Drosophila Calcium Channels and Twinning of Calcium and Voltage-Activated Potassium Channels

1986 • 38 citations

Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila

1982 • 38 citations

Properties of ShB AType potassium channels expressed in Shaker mutant drosophil by germline transformation

1989 • 36 citations

Neurogenetic Analysis ofDrosophilaMutations Affecting Sodium Channels: Synergistic Effects on Viability and Nerve Conduction in Double Mutants Involvingtip-E

1986 • 34 citations

Alteration of potassium channel gating: Molecular analysis of the drosophila Sh5 mutation

1990 • 31 citations

Actions of dendrotoxin on K+ channels and neuromuscular transmission in Drosophila melanogaster, and its effects in synergy with K+ channel-specific drugs and mutations

1989 • 31 citations

Temperature-sensitive paralytic mutations on the second and third chromosomes ofDrosophila melanogaster

1982 • 27 citations

enhancer of seizure: A New Genetic Locus in Drosophila melanogaster Defined by Interactions With Temperature-Sensitive Paralytic Mutations

1987 • 26 citations

Molecular Neurobiology

1988 • 24 citations

Single-channel K+ currents inDrosophila muscle and their pharmacological block

1991 • 23 citations

Isolation of Drosophila genomic clones homologous to the eel sodium channel gene.

1987 • 20 citations

Cell culture approaches to invertebrate neuroscience

1988 • 18 citations

Pharmacological characterization of sodium channels in the primary culture of individual Drosophila embryos: Neurons of a mutant deficient in a putative sodium channel gene

1989 • 9 citations

Analysis of Mutations Affecting Sodium Channels in Drosophila^a

1986 • 9 citations

Two distinct mechanisms are responsible for single K channel block by internal tetraethylammonium ions

1989 • 8 citations

Characterization of single non-inactivating potassium channels in primary neuronal cultures of Drosophila

1989 • 7 citations

Genetic and Molecular Analysis of a Gene Encoding Sodium Channels in Drosophila

1989 • 5 citations

Genetic analysis of ion channels in Drosophila.

1991 • 2 citations

Deleted Work

1955 • 0 citations