Gene Dosage Compensation in Drosophila Melanogaster

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME

1972 • 609 citations

Further studies on the nature and causes of gene mutations.

1932 • 524 citations

Enhancers and eukaryotic gene transcription

1985 • 515 citations

Transformation of white locus DNA in Drosophila: Dosage compensation, zeste interaction, and position effects

1984 • 388 citations

The effect of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene

1983 • 368 citations

AUTOREGULATORY FUNCTIONING OF A DROSOPHILA GENE PRODUCT THAT ESTABLISHES AND MAINTAINS THE SEXUALLY DETERMINED STATE

1984 • 269 citations

SELECTED TOPICS IN CHROMATIN STRUCTURE

1985 • 253 citations

Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line

1983 • 248 citations

TWO CLOSELY LINKED MUTATIONS IN DROSOPHILA MELANOGASTER THAT ARE LETHAL TO OPPOSITE SEXES AND INTERACT WITH DAUGHTERLESS

1978 • 248 citations

SEX DETERMINATION AND DOSAGE COMPENSATION IN DROSOPHILA MELANOGASTER

1983 • 235 citations

Molecular structure of the bilin binding protein (BBP) from Pieris brassicae after refinement at 2.0 Å resolution

1987 • 228 citations

Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene

1986 • 223 citations

The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the drosophila genome

1983 • 202 citations

Synthesis of Ribonucleic Acid by the X-Chromosomes of Drosophila melanogaster and the Problem of Dosage Compensation

1965 • 196 citations

Multiple upstream regulatory elements control the expression of the Drosophila white gene.

1985 • 187 citations

Control of X chromosome transcription by the maleless gene in Drosophila

1980 • 187 citations

MALE-SPECIFIC LETHAL MUTATIONS OF DROSOPHILA MELANOGASTER

1980 • 175 citations

An expandable gene that encodes a Drosophila glue protein is not expressed in variants lacking remote upstream sequences

1982 • 165 citations

Differentiation in the salivary glands of Drosophila melanogaster: Characterizaion of the glue proteins and their developmental appearance

1976 • 162 citations

A GENE IN DROSOPHILA MELANOGASTER THAT TRANSFORMS FEMALES INTO MALES

1945 • 160 citations

(dC-dA)n.(dG-dT)n sequences have evolutionarily conserved chromosomal locations in Drosophila with implications for roles in chromosome structure and function.

1987 • 158 citations

Chromosome puff activity and protein synthesis in larval salivary glands of Drosophila melanogaster.

1975 • 155 citations

DOUBLESEX, A RECESSIVE GENE THAT TRANFORMS BOTH MALES AND FEMALES OF DROSOPHILA INTO INTERSEXES

1965 • 153 citations

NORMAL FEMALE GERM CELL DIFFERENTIATION REQUIRES THE FEMALE X CHROMOSOME TO AUTOSOME RATIO AND EXPRESSION OF SEX-LETHAL IN DROSOPHILA MELANOGASTER

1985 • 149 citations

The link between dosage compensation and sex differentiation in Drosophila melanogaster

1981 • 145 citations

Is sex determination in germ line and soma controlled by separate genetic mechanisms?

1978 • 139 citations

Separable cis-acting control elements for expression of the white gene of Drosophila.

1985 • 123 citations

Autosomal mutations that interfere with sex determination in somatic cells of Drosophila have no direct effect on the germline

1982 • 122 citations

The interaction between daughterless and sex-lethal in triploids: A lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogaster

1983 • 110 citations

A FEMALE-SPECIFIC LETHAL LESION IN AN X-LINKED POSITIVE REGULATOR OF THE DROSOPHILA SEX DETERMINATION GENE, SEX-LETHAL

1986 • 105 citations

Sex determination and dosage compensation in Drosophila melanogaster : production of male clones in XX females

1983 • 102 citations

Direct correlation between a chromosome puff and the synthesis of a larval saliva protein in Drosophila melanogaster

1977 • 98 citations

Autosomal dosage compensation Drosophila melanogaster strains trisomic for the left arm of chromosome 2.

1982 • 96 citations

Glucose-6-Phosphate Dehydrogenase in Drosophila : X-Linked Electrophoretic Variants

1964 • 94 citations

A SEX-SPECIFIC, TEMPERATURE-SENSITIVE MATERNAL EFFECT OF THE DAUGHTERLESS MUTATION OF DROSOPHILA MELANOGASTER

1976 • 83 citations

X-Linked 6-Phosphogluconate Dehydrogenase in Drosophila : Subunit Associations

1965 • 81 citations

Remote regulatory sequences of the Drosophila glue gene sgs3 as revealed by P-element transformation

1985 • 79 citations

The X-chromosome in the larval salivary glands of hybrids Drosophila insularis � Drosophila tropicalis

1956 • 74 citations

Sex-lethal, A Link between Sex Determination and Sexual Differentiation in Drosophila melanogaster

1985 • 74 citations

Regulation of gene function: A comparison of enzyme activity levels in relation to gene dosage in diploids and triploids of Drosophila melanogaster

1973 • 72 citations

The Sex-lethal gene of drosophila: DNA alterations associated with sex-specific lethal mutations

1985 • 71 citations

DOSAGE COMPENSATION FOR ENZYME ACTIVITIES IN Drosophila melanogaster

1969 • 71 citations

DNA sequence changes in an upstream DNase I-hypersensitive region are correlated with reduced gene expression.

1983 • 71 citations

Dosage compensation in Drosophila melanogaster triploids

1973 • 70 citations

MALELESS, A RECESSIVE AUTOSOMAL MUTANT OF DROSOPHILA MELANOGASTER THAT SPECIFICALLY KILLS MALE ZYGOTES

1975 • 69 citations

Cloning and characterization of a dispersed, multicopy, X chromosome sequence in Drosophila melanogaster.

1987 • 68 citations

Studies on the genetic control of tryptophan pyrrolase in Drosophila Melanogaster

1971 • 66 citations

X-Linked Electrophoretic Variation in 6-phosphogluconate dehydrogenase

1966 • 64 citations

THE FIFTH HUSKINS MEMORIAL LECTUREDosage Compensation—Development of a Concept and New Facts

1960 • 63 citations

Chromosomal basis of dosage compensation inDrosophila: I. Cellular autonomy of hyperactivity of the maleX-chromosome in salivary glands and sex differentiation

1969 • 60 citations

SEGMENTAL ANEUPLOIDY AND ENZYME ACTIVITY AS A METHOD FOR CYTOGENETIC LOCALIZATION IN DROSOPHILA MELANOGASTER

1974 • 58 citations

Clonal analysis ofsex-lethal, a gene needed for female sexual development inDrosophila melanogaster

1982 • 55 citations

Cis-acting sequences which regulate expression of the Sgs-4 glue protein gene of Drosophila.

1986 • 51 citations

Branched chromosomes as symmetrical duplications

1936 • 50 citations

Studies on the sex-specific lethals of Drosophila melanogaster. III. A third chromosome male-specific lethal mutant.

1981 • 48 citations

The X-linked α-chain gene of Drosophila LSP-1 does not show dosage compensation

1979 • 47 citations

A NOTE ON THE MATERNAL EFFECT MUTANTS DAUGHTERLESS AND ABNORMAL OOCYTE IN DROSOPHILA MELANOGASTER

1973 • 47 citations

Molecular genetic aspects of sex determination in Drosophila

1987 • 47 citations

Mutations affecting dosage compensation in Drosophila melanogaster: Effects in the germline

1986 • 46 citations

Gene dosage compensation in metafemales (3X; 2A) of Drosophila

1974 • 44 citations

Sex determination: a hypothesis based on noncoding DNA.

1985 • 43 citations

Genetic analysis of the larval secretion gene Sgs-4 and its regulatory chromosome sites in Drosophila melanogaster

1981 • 43 citations

The Dosage compensation ofDrosophilaand mammals as showing the accuracy of the normal type

1966 • 42 citations

THE ROLE OF SEXUALITY IN DOSAGE COMPENSATION IN DROSOPHILA

1969 • 41 citations

INTERACTIONS BETWEEN SEX-TRANSFORMATION MUTANTS OF DROSOPHILA MELANOGASTER. I. HEMOLYMPH VITELLOGENINS AND GONAD MORPHOLOGY

1981 • 41 citations

Gene modulation in Drosophila: Dosage compensation and relocated v + genes

1971 • 39 citations

Transformation of salivary gland secretion protein gene Sgs-4 in Drosophila: stage- and tissue-specific regulation, dosage compensation, and position effect.

1985 • 39 citations

DOSAGE COMPENSATION IN DROSOPHILA MELANOGASTER TRIPLOIDS. II. GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY

1973 • 39 citations

Dosage compensation in Drosophila

1986 • 38 citations

MALE-SPECIFIC LETHAL MUTATIONS OF DROSOPHILA MELANOGASTER. II. PARAMETERS OF GENE ACTION DURING MALE DEVELOPMENT

1983 • 37 citations

Transcription rates of individual polytene chromosome bands: effects of gene dose and sex in Drosophila

1972 • 36 citations

REGULATION OF GENE ACTIVITY BY DOSAGE COMPENSATION AT THE CHROMOSOMAL LEVEL IN DROSOPHILA

1975 • 35 citations

ANALYSIS OF THE DOSAGE COMPENSATION OF A SPECIFIC TRANSCRIPT IN DROSOPHILA MELANOGASTER

1986 • 34 citations

Isolation and characterization of the glucose-6-phosphate dehydrogenase gene of Drosophila melanogaster

1985 • 34 citations

Studies on the sex-specific lethals of Drosophila melanogaster. VII. Sex-specific lethals that do not affect dosage compensation.

1984 • 31 citations

Developmental control of transduced dopa decarboxylase genes in D. melanogaster

1985 • 29 citations

Gene modulation in Drosophila: Dosage compensation of Pgd + and Zw + genes

1973 • 29 citations

Dosiskompensation und Dosiseffekt f�r RNS-Synthese in Chromosomen-Puffs von Drosophila melanogaster

1970 • 28 citations

X-Linked gene activity in metamales (XY; 3A) of Drosophila

1977 • 28 citations

X-chromosome transcription in Drosophila

1980 • 28 citations

STUDIES ON THE SEX-SPECIFIC LETHALS OF DROSOPHILA MELANOGASTER. II. FURTHER STUDIES ON A MALE-SPECIFIC LETHAL GENE, MALELESS

1976 • 27 citations

REGULATION OF GENE FUNCTION: A COMPARISON OF X-LINKED ENZYME ACTIVITY LEVELS IN NORMAL AND INTERSEXUAL TRIPLOIDS OF DROSOPHILA MELANOGASTER

1973 • 27 citations

Intersexuality resulting from the interaction of sex-specific lethal mutations in Drosophila melanogaster

1982 • 27 citations

Dosage Compensation and Effect for RNA Synthesis in Chromosome Puffs of Drosophila melanogaster

1970 • 26 citations

EFFECT OF SEX TRANSFORMATION GENES ON GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY IN DROSOPHILA MELANOGASTER

1966 • 25 citations

Dosage compensation of sex-linked genes in Drosophila melanogaster

1973 • 25 citations

DOSAGE COMPENSATION IN DROSOPHILA: NADP-ENZYME ACTIVITIES AND CROSS-REACTING MATERIAL

1983 • 24 citations

Dosage compensation of X-linked heat-shock puffs in Drophila pseudoobscura

1980 • 23 citations

A small region on the X chromosome of Drosophila regulates a key gene that controls sex determination and dosage compensation

1985 • 23 citations

STUDIES ON THE SEX-SPECIFIC LETHALS OF DROSOPHILA MELANOGASTER. V. SEX TRANSFORMATION CAUSED BY INTERACTIONS BETWEEN A FEMALE-SPECIFIC LETHAL, Sxl f#1, AND THE MALE-SPECIFIC LETHALS mle(3)132, msl-2 27, AND mle

1982 • 22 citations

The role of genetic balance in control of transcription rate in the X-chromosome of Drosophila melanogaster

1974 • 22 citations

STUDIES ON THE SEX-SPECIFIC LETHALS OF DROSOPHILA MELANOGASTER. IV. GYNANDROMORPH ANALYSIS OF THREE MALE-SPECIFIC LETHALS, mle, msl-2 27 AND mle(3)132

1982 • 21 citations

Chromosomal basis of dosage compensation in Drosophila: II. The DNA replication patterns of the male X-chromosome in an autosome—X insertion in D. melanogaster

1970 • 20 citations

INTERACTION OF POLY-<scp>L</scp>-LYSINE WITH CHROMATIN

1973 • 19 citations

Chromosomal basis of dosage compensation in Drosophila

1971 • 19 citations

LACK OF DOSAGE COMPENSATION FOR AN AUTOSOMAL GENE RELOCATED TO THE X CHROMOSOME IN DROSOPHILA MELANOGASTER

1977 • 18 citations

DOSAGE COMPENSATION OF SERINE-4 TRANSFER RNA IN DROSOPHILA MELANOGASTER

1982 • 18 citations

Dosage compensation at the sgs4 locus of Drosophila melanogaster

1986 • 17 citations

Location and regulation of Drosophila fumarase

1977 • 17 citations

Pigmentation Mosaicism in Intersexes of Drosophila

1966 • 17 citations

The relationship between gene dosage, gene expression, and sex in Drosophila

1982 • 16 citations

Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster

1974 • 16 citations

Dosage compensation is transcriptionally regulated in autosomal trisomies of Drosophila

1984 • 16 citations

Binding of thymus histone F1 and E. coli RNA polymerase to DNA of Polytene Chromosomes of Drosophila

1973 • 15 citations

Chromosomal basis of dosage compensation in Drosophila. X. Assessment of hyperactivity of the male X in situ

1981 • 15 citations

RNA SYNTHESIS BY EXOGENOUS RNA POLYMERASE ON CYTOLOGICAL PREPARATIONS OF CHROMOSOMES

1973 • 15 citations

Genetic analysis of the mutationFemale-lethalinDrosophila melanogaster

1978 • 14 citations

THE APPLICATION OF THE MAIZE-DERIVED GENE COMPETITION MODEL TO THE PROBLEM OF DOSAGE COMPENSATION IN DROSOPHILA

1973 • 13 citations

Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila

1976 • 11 citations

In situ transcription analysis of chromatin template activity of the X-chromosome of Drosophila following high molar NaCl treatment

1981 • 10 citations

Gene dosage compensation in trisomies of Drosophila melanogaster

1985 • 10 citations

Genetics and physiological expression of ?-hydroxy acid dehydrogenase in Drosophila

1978 • 10 citations

The LSP1-? gene is not dosage compensated in the Drosophila melanogaster species subgroup

1982 • 9 citations

RNA synthesis in Drosophila melanogaster polytene chromosomes indications of simultaneous dosage compensation and dosage effect in X chromosomes

1974 • 9 citations

An X chromosome locus in Drosophila melanogaster that enhances survival of the triplo‐lethal genotype, Dp‐(Tpl)

1981 • 9 citations

Regulation of dosage compensation in X-chromosomal trisomies of Drosophila melanogaster

1985 • 8 citations

Ontogenetic expression of fumarase activity in Drosophila melanogaster

1972 • 7 citations

Studies on the sex-specific lethals of Drosophila melanogaster. VIII. Enhancement and suppression of Sxl expression by mle(3)132.

1984 • 7 citations

Chromatin structure and transcriptional activity of an X-linked heat shock gene in drosophila pseudoobscura.

1983 • 6 citations

Dosage compensation and template organisation in Drosophila: In situ transcriptional analysis of the chromatin template activity of the X and autosomes of D. melanogaster strains trisomic for the left arm of the second and third chromosomes

1986 • 4 citations

A different level ofX-chromosomal transcription in an In(1)BM²(reinverted) strain and in its hyperploid derivatives resolves anX-coded regulatory activity for dosage compensation inDrosophila

1986 • 4 citations

Phenogenetics of triploid intersexes inDrosophila melanogaster

1985 • 3 citations

A genetic and biochemical study of a temperature-sensitive vermilion mutation in Drosophila melanogaster

1974 • 1 citations