Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic Neuropathy

1992 • 1,097 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood

1987 • 695 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Amitriptyline versus placebo in postherpetic neuralgia

1982 • 563 citations

MEXILETINE FOR TREATMENT OF CHRONIC PAINFUL DIABETIC NEUROPATHY

1988 • 535 citations

The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

1990 • 455 citations

Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction

1992 • 452 citations

Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain

1993 • 447 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Desipramine relieves postherpetic neuralgia

1990 • 270 citations

Imipramine Treatment of Painful Diabetic Neuropathy

1984 • 259 citations

High Doses of Spinal Morphine Produce a Nonopiate Receptormediated Hyperesthesia

1986 • 256 citations

Association of pain relief with drug side effects in postherpetic neuralgia: A single-dose study of clonidine, codeine, ibuprofen, and placebo

1988 • 251 citations

Capillary number and percentage closed in human diabetic sural nerve.

1985 • 216 citations

Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat

1992 • 209 citations

Mechanism of pain in diabetic peripheral neuropathy

1984 • 206 citations

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

1990 • 206 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

Narcotics and diabetes. I. The effects of streptozotocin-induced diabetes on the antinociceptive potency of morphine.

1981 • 156 citations

Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double‐blind cross‐over study.

1990 • 138 citations

Double blind study of the effects of diphenylhydantoin sodium on diabetic neuropathy.

1978 • 135 citations

Peripheral Diabetic Neuropathy Treated With Amitriptyline and Fluphenazine

1977 • 132 citations

Severe Early-Onset Polyneuropathy in Insulin-Dependent Diabetes Mellitus

1992 • 130 citations

Alterations in Physiologic Functions and in Brain Monoamine Content in Streptozocin-Diabetic Rats

1986 • 130 citations

Diabetes-induced alteration in brain monoamine metabolism in rats.

1986 • 123 citations

Treatment of Painful Diabetic Neuropathy with Topical Capsaicin

1989 • 108 citations

Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by μ-opioid agonists, but not by δ- and κ-opioid agonists

1992 • 107 citations

Effect of Hyperglycemia on Pain Perception and on Efficacy of Morphine Analgesia in Rats

1988 • 102 citations

Transdermal clonidine versus placebo in painful diabetic neuropathy

1992 • 98 citations

Hyperalgesia in spontaneous and experimental animal models of diabetic neuropathy

1987 • 93 citations

Streptozocin Diabetes Alters Immunoreactive β-Endorphin Levels and Pain Perception After 8 wk in Female Rats

1986 • 85 citations

A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial

1992 • 84 citations

Treatment of chronic painful diabetic neuropathy with intravenous lidocaine infusion.

1986 • 83 citations

Behavioural evidence that systemic morphine may modulate a phasic pain-related behaviour in a rat model of peripheral mononeuropathy

1991 • 82 citations

Pain Relief in Diabetic Neuropathy: The Effectiveness of Imipramine and Related Drugs

1985 • 82 citations

Streptozotocin‐Induced Diabetes Reduces Brain Serotonin Synthesis in Rats

1986 • 80 citations

Glycemic control of pain threshold in diabetic and control rats

1990 • 62 citations

Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli

1991 • 60 citations

Effect of hyperglycemia on pain threshold in alloxan-diabetic rats

1990 • 59 citations

Can opiates relieve neuropathic pain?

1988 • 58 citations

Narcotics and diabetes. II. Streptozotocin-induced diabetes selectively alters the potency of certain narcotic analgesics. Mechanism of diabetes: morphine interaction.

1981 • 58 citations

Streptozotocin and alloxan produce alterations in rat brain monoamines independently of pancreatic beta cells destruction

1990 • 56 citations

A Trial of Amitriptyline and Fluphenazine in the Treatment of Painful Diabetic Neuropathy

1986 • 52 citations

Streptozocin diabetes alters immunoreactive beta-endorphin levels and pain perception after 8 wk in female rats

1986 • 52 citations

Peripheral Diabetic Neuropathy

1988 • 51 citations

Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats

1986 • 50 citations

Imipramine treatment of painful diabetic neuropathy

1984 • 45 citations

Effect of hyperglycemia on pain perception and on efficacy of morphine analgesia in rats

1988 • 43 citations

Altered Behavior and Neurochemistry During Short-Term Insulin Withdrawal in Streptozocin-Induced Diabetic Rats

1991 • 40 citations

Zur natur der antiketogenen wirkung von glycerin und fructose

1962 • 39 citations

Morphine dependence and diabetes. I. The development of morphine dependence in streptozotocin-diabetic rats and spontaneously diabetic C57BL/KsJ mice.

1986 • 28 citations

Relief of Diabetic Neuropathy with Fluoxetine

1989 • 23 citations

Reply to Howard L. Fields on ‘Can opiates relieve neuropathic pain?’

1988 • 22 citations

Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading

1987 • 21 citations

Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine

1977 • 21 citations

Altered behavior and neurochemistry during short-term insulin withdrawal in streptozocin-induced diabetic rats

1991 • 16 citations

A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy

1986 • 7 citations