Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid.

1983 • 231 citations

Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.

1990 • 194 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Molecular aspects of the metastatic cascade

1989 • 193 citations

Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumours

1991 • 192 citations

Expression and activity of MMPS and their regulators in ovarian cancer

1994 • 168 citations

Human Skin Fibroblast Collagenase: Interaction with Substrate and Inhibitor

1985 • 167 citations

Tumor cell stimulation of collagenase production by fibroblasts

1982 • 166 citations

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

1994 • 162 citations

Expression of MMP‐7(pump‐1) mRNA in human colorectal cancers

1993 • 154 citations

Distribution of Extracellular Matrix Proteins in Pancreatic Ductal Adenocarcinoma and Its Influence on Tumor Cell Proliferation in Vitro

1987 • 138 citations

Expression of gelatinase A and TIMP-2 mRNAs in desmoplastic fibroblasts in both mammary carcinomas and basal cell carcinomas of the skin.

1993 • 136 citations

Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia

1994 • 130 citations

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

1990 • 124 citations

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase

1988 • 120 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity.

1991 • 97 citations

A clinicopathologic study on neural invasion in cancer of the pancreatic head

1992 • 96 citations

Tumour basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance

1986 • 93 citations

Immunohistochemical detection of laminin in 98 human breast carcinomas

1986 • 82 citations

Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor

1993 • 73 citations

The Role of the Matrix Metalloproteinase Stromelysin in the Progression of Squamous Cell Carcinomas

1991 • 72 citations

Correlation between spontaneous metastatic potential and type I collagenolytic activity in a human pancreatic cancer cell line (SUIT-2) and sublines

1992 • 69 citations

Aetiology of pancreatic cancer

1990 • 59 citations

Expression Pattern of Metalloproteinases and Their Inhibitors Changes with the Progression of Human Sporadic Colorectal Neoplasia

1993 • 58 citations

Long-term survival after resection of ampullary carcinoma is associated independently with tumor grade and a new staging classification that assesses local invasiveness

1988 • 57 citations

Extraction of type‐IV collagenase/gelatinase from plasma membranes of human cancer cells

1990 • 51 citations

The spread and prognosis of carcinoma in the region of the pancreatic head

1989 • 46 citations

Surgical resection for cancer of the pancreas

1990 • 44 citations

Carcinoma of the Pancreas: a Clinicopathologic Study of 96 Cases with Immunohistochemical Observations

1989 • 40 citations

Distribution of type IV collagen in pancreatic adenocarcinoma and chronic pancreatitis.

1994 • 35 citations

Transforming growth factor beta 1 regulation of metalloproteinase production in cultured human cervical epithelial cells.

1994 • 35 citations

Interstitial collagenase gene expression in colonic neoplasia.

1993 • 35 citations

Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line.

1990 • 34 citations

Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm?

1991 • 12 citations

Extraction of type IV collagenase/gelatinase from plasma membranes of human pancreatic cancer cells.

1992 • 11 citations