Evidence for an Altered Protein Kinase C (PKC) Signaling Pathways in Psoriasis

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Biology of interleukin 1

1988 • 1,547 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis

1987 • 668 citations

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

1990 • 609 citations

Molecular Cloning, Occurrence, and Expression of a Novel Partially Secreted Protein “Psoriasin” That Is Highly Up-Regulated in Psoriatic Skin

1991 • 410 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Molecular Cloning and Expression of a Novel Keratinocyte Protein (Psoriasis-associated fatty acid-binding protein [PA-FABP]) that Is Highly Up-Regulated in Psoriatic Skin and that Shares Similarity to Fatty Acid-Binding Proteins

1992 • 257 citations

The pathophysiology of psoriasis

1991 • 239 citations

Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.

1988 • 224 citations

Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.

1991 • 212 citations

The immunology of psoriasis

1992 • 193 citations

Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues

1988 • 188 citations

Comprehensive two‐dimensional gel protein databases offer a global approach to the analysis of human cells: The transformed amnion cells (AMA) master database and its link to genome DNA sequence data

1990 • 158 citations

Interleukin-1 Receptor antagonist Production by Human Keratinocytes

1992 • 152 citations

IL-1 activity is reduced in psoriatic skin. Decreased IL-1 alpha and increased nonfunctional IL-1 beta.

1990 • 140 citations

Interleukin-1 receptor antagonist in normal and psoriatic epidermis.

1992 • 126 citations

The human keratinocyte two‐dimensional gel protein database (update 1992): Towards an integrated approach to the study of cell proliferation, differentiation and skin diseases

1992 • 125 citations

Decreased Protein Kinase C Activity in Psoriatic Versus Normal Epidermis

1987 • 123 citations

Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo

1992 • 121 citations

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

1988 • 121 citations

A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases

1989 • 120 citations

lonomycin-regulated phosphorylation of the myeloid calcium-binding protein p14

1989 • 118 citations

Transcripts encoding protein kinase C‐α, ‐ϵ, ‐ζ, and ‐ζ are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells

1992 • 111 citations

The Leucocyte L1 Protein: Identity with the Cystic Fibrosis Antigen and the Calcium‐Binding MRP‐8 and MRP‐14 Macrophage Components

1988 • 109 citations

Psoriasis: Cell proliferation

1984 • 104 citations

Sphingosine Inhibits Phorbol Ester-Induced Inflammation, Ornithine Decarboxylase Activity, and Activation of Protein Kinase C in Mouse Skin

1988 • 99 citations

Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes.

1987 • 91 citations

Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.

1991 • 75 citations

The interleukin 1 receptor

1989 • 72 citations

Microsequencing of proteins recorded in human two‐dimensional gel protein databases

1991 • 63 citations

Interleukin-1 in Human Skin: Dysregulation in Psoriasis

1990 • 61 citations

Increased Phospholipase C-Catalyzed Hydrolysis of Phosphatidylinositol-4,5-Bisphosphate and 1,2-sn-Diacylglycerol Content in Psoriatic Involved Compared to Uninvolved and Normal Epidermis

1990 • 54 citations

Identification of a group of proteins that are strongly up‐regulated in total epidermal keratinocytes from psoriatic skin

1990 • 53 citations

A comprehensive two‐dimensional gel protein database of noncultured unfractionated normal human epidermal keratinocytes: Towards an integrated approach to the study of cell proliferation, differentiation and skin diseases

1991 • 47 citations

Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine

1992 • 35 citations

Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells.

1990 • 25 citations

The antipsoriatic drug, anthralin, inhibits protein kinase C — implications for its mechanism of action

1992 • 22 citations

Increased Protein Kinase C Activity in Fibroblast Membranes From Psoriatic Patients

1988 • 20 citations

Anti-proliferative effects of protein kinase C inhibitors in human keratinocytes

1992 • 15 citations

Protein kinase C activity in normal and psoriatic cells: cultures of fibroblasts and lymphocytes

1991 • 14 citations

Psoriatic skin reveals the in vivo presence of an epidermal IL-1 inhibitor

1992 • 7 citations