Signal transduction pathways that regulate skeletal muscle gene expression.

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

1987 • 480 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Hormones, Growth Factors, and Myogenic Differentiation

1991 • 399 citations

Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

1989 • 349 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.

1990 • 316 citations

Myogenin and MyoD join a family of skeletal muscle genes regulated by electrical activity.

1991 • 314 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

Helix-loop-helix proteins as regulators of muscle-specific transcription.

1993 • 293 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

Effect of a tumour promoter on myogenesis

1977 • 259 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Insulin-like Growth Factors (IGF) in Muscle Development

1989 • 228 citations

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

1987 • 221 citations

Fibroblast Growth Factor and Transforming Growth Factor β Repress Transcription of the Myogenic Regulatory Gene MyoD1

1989 • 212 citations

Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.

1986 • 196 citations

Effect of oncogenic virus on muscle differentiation.

1975 • 182 citations

Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation.

1989 • 174 citations

Temperature-sensitive expression of differentiation in transformed myoblasts

1975 • 172 citations

Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding.

1991 • 167 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

Distinctive effects of the viral oncogenes myc, erb, fps, and src on the differentiation program of quail myogenic cells.

1985 • 141 citations

Regulation of muscle AChR α subunit gene expression by electrical activity: Involvement of protein kinase C and Ca 2+

1989 • 140 citations

Spatial restriction of AChR gene expression to subsynaptic nuclei

1992 • 122 citations

Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene.

1989 • 110 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

cAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD

1993 • 98 citations

Cyclic AMP-Dependent Protein Kinase Inhibits the Activity of Myogenic Helix-Loop-Helix Proteins

1992 • 95 citations

Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T.

1990 • 92 citations

Protein kinase C couples membrane excitation to acetylcholine receptor gene inactivation in chick skeletal muscle

1992 • 88 citations

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.

1992 • 88 citations

Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins.

1991 • 82 citations

Influence of innervation of myogenic factors and acetylcholine receptor α-subunit mRNAs

1991 • 77 citations

Mapping of myogenin transcription during embryogenesis using transgenes linked to the myogenin control region.

1992 • 76 citations

Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes.

1988 • 72 citations

Response of myogenic determination factors to cessation and resumption of electrical activity in skeletal muscle: A possible role for myogenin in denervation supersensitivity

1992 • 71 citations

Neural regulation of gene expression by an acetylcholine receptor promoter in muscle of transgenic mice

1989 • 69 citations

Protein kinase C as a transducer of nuclear signals.

1993 • 68 citations

Myogenin and acetylcholine receptor alpha gene promoters mediate transcriptional regulation in response to motor innervation.

1994 • 68 citations

Mitogenic repression of myogenin autoregulation.

1991 • 64 citations

Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels.

1989 • 52 citations

Regulation of differentiation of the BC3H1 muscle cell line through cAMP-dependent and -independent pathways.

1988 • 49 citations

Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C.

1991 • 48 citations

Oncogenes and muscle differentiation: multiple mechanisms of interference.

1994 • 43 citations

Transcription of muscle-specific genes is repressed by reactivation of pp60v-src in postmitotic quail myotubes.

1991 • 43 citations

Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization.

1991 • 41 citations

Role of cell division in differentiation of myoblasts infected with a temperature-sensitive mutant of Rous sarcoma virus.

1984 • 33 citations

Development of the neuromuscular synapse

1993 • 29 citations

Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells.

1991 • 25 citations

Selective effect of Rous sarcoma virus src gene expression on contractile protein synthesis in chick embryo myotubes.

1983 • 21 citations

Differential Effects of Fibroblast Growth Factor on Insulin Receptor and Muscle Specific Protein Gene Expression in BC3H-1 Myocytes

1990 • 18 citations

Transcription Factors Controlling Muscle-Specific Gene Expression

1993 • 5 citations