A Novel Bcl-x Isoform Connected to the T Cell Receptor Regulates Apoptosis in T Cells

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

1996 • 930 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.

1985 • 818 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Chapter 9 The End of the (Cell) Line: Methods for the Study of Apoptosis in Vitro

1995 • 569 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

1995 • 289 citations

Bclx regulates the survival of double-positive thymocytes.

1995 • 249 citations

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.

1992 • 234 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Increased membrane permeability of apoptotic thymocytes: A flow cytometric study

1993 • 200 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

[1] Isolation and utilization of epidermal keratinocytes for oncogene research

1995 • 158 citations

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

1995 • 134 citations

Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.

1994 • 133 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

bcl‐2, a novel reguator of cell death

1995 • 128 citations

The thermal stability of oligonucleotide duplexes is sequence independent in tetraalkylammonium salt solutions: application to identifying recombinant DNA clones

1988 • 120 citations

Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli.

1995 • 115 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition

1994 • 105 citations

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

1993 • 87 citations

The effects of chronic infection with a superantigen-producing virus.

1992 • 83 citations

Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein.

1993 • 68 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Developmental regulation of bcl-2 expression in the thymus.

1994 • 51 citations

Receptor diversity of insulin-specific T cell lines from C57BL (H-2b) mice.

1987 • 50 citations

Role of infused CD8+ cells in the induction of peripheral tolerance.

1994 • 47 citations

A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death

1995 • 38 citations

CD44 and Other Cell Interaction Molecules Contributing to B Lymphopoiesis

1993 • 32 citations

Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen.

1994 • 15 citations

Measurement of apoptosis in heterogenous cell populations

1997 • 15 citations

[23] Antisense techniques

1995 • 14 citations

Alloreactivity of an OVA-specific T-cell clone

1987 • 13 citations

Overexpressed Bcl-xL prevents bacterial superantigen-induced apoptosis of thymocytes in vitro

1997 • 6 citations

The Raising of a Polyclonal Antiserum to a Protein

2003 • 5 citations

Influence of H-2 isoantibody on electrophoretic behavior of EL4 lymphoma cells.

1965 • 5 citations

The nature of topogenic sequences determines the transport competence of topological mutants of neutral endopeptidase-24.11

1995 • 3 citations