Alcohol and hepatocellular carcinoma

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

2004 • 1,201 citations

Risk Factors for Hepatocellular Carcinoma among Patients with Chronic Liver Disease

1993 • 1,118 citations

Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus

2002 • 751 citations

Alcohol and Hepatocellular Carcinoma: The Effect of Lifetime Intake and Hepatitis Virus Infections in Men and Women

2002 • 662 citations

A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis

1993 • 618 citations

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

2001 • 567 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

2001 • 436 citations

Risk Factors for the Rising Rates of Primary Liver Cancer in the United States

2000 • 425 citations

Alcohol and the Liver

1992 • 421 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Prevalence of DSM-IV Alcohol Abuse and Dependence: United States, 1992.

1994 • 290 citations

Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study

1999 • 250 citations

Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma

1991 • 235 citations

Incidence and Cofactors of Hepatitis C Virus-related Hepatocellular Carcinoma: A Prospective Study of 12,008 Men in Taiwan

2003 • 235 citations

Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: A case-control study in Italy

1997 • 232 citations

Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Livers:A Clinico-Histopathologic Study of 804 North American Patients

1996 • 228 citations

Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population.

1991 • 199 citations

The effect of chronic habitual alcohol intake on the development of liver cirrhosis and hepatocellular carcinoma: Relation to hepatitis B surface antigen carriage

1982 • 153 citations

Cocarcinogenic effects of alcohol in hepatocarcinogenesis

2002 • 153 citations

Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: The role of HCV genotypes and the synergism with hepatitis B virus and alcohol

1999 • 150 citations

Prospective Study of Hepatitis B and C Viral Infections, Cigarette Smoking, Alcohol Consumption, and Other Factors Associated with Hepatocellular Carcinoma Risk in Japan

2000 • 144 citations

Association between hepatitis C virus antibodies and hepatocellular carcinoma in Taiwan.

1991 • 139 citations

Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver

1998 • 134 citations

Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis

1996 • 130 citations

Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1

2001 • 129 citations

Pathogenic factors in cirrhosis with and without hepatocellular carcinoma: A multicenter Italian study

1994 • 122 citations

Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma

2001 • 111 citations

Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C

2000 • 107 citations

Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption

1997 • 107 citations

Pathogenic Factors in Cirrhosis With and Without Hepatocellular Carcinoma: A Multicenter Italian Study

1994 • 105 citations

Follow‐up study of hbs ag‐positive blood donors with special reference to effect of drinking and smoking on development of liver cancer

1984 • 103 citations

Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

1996 • 93 citations

Restoration of retinoic acid concentration supresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver

2001 • 89 citations

Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver

1999 • 88 citations

Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease

1991 • 83 citations

Etiology of hepatocellular carcinoma in Italian patients with and without cirrhosis.

2000 • 81 citations

Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping

2002 • 70 citations

HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma

2002 • 64 citations

Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation

2000 • 60 citations

Alcohol consumption as A risk factor for hepatocellular carcinoma in urban Southern African blacks

1992 • 58 citations

Binge drinking on rise in UK and elsewhere

2003 • 56 citations

RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.

1996 • 55 citations

Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking.

1994 • 53 citations

High malignancy of hepatocellular carcinoma in alcoholic patients with hepatitis C virus

1997 • 48 citations

Genetic Polymorphisms of Aldehyde Dehydrogenase 2, Cytochrome p450 2E1 for Liver Cancer Risk in HCV Antibody-Positive Japanese Patients and the Variations of CYP2E1 mRNA Expression Levels in the Liver due to its Polymorphism

2003 • 45 citations

Hepatocellular Carcinoma in Liver Cirrhosis: A Prospective Study

1993 • 40 citations

Hepatocellular Carcinoma in Southern Germany: Epidemiological and Clinicopathological Characteristics and Risk Factors

2001 • 39 citations

Alcohol and Other Chemicals in the Development of Hepatocellular Carcinoma

1996 • 33 citations

Minor Role of Hepatitis B and C Virus Infection in the Etiology of Hepatocellular Carcinoma in a Low-Endemic Area

1996 • 30 citations

Korean Status of Alcoholics and Alcohol‐Related Health Problems

1998 • 25 citations

A COMPARATIVE STUDY OF ALCOHOLIC PATIENTS IN JOS, NIGERIA, AND IN CASTROP-RAUXEL, GERMANY

1994 • 23 citations

Korean Status of Alcoholics and Alcohol-Related Health Problems

1998 • 21 citations

Effect of Heavy Alcohol Intake on Long‐term Results after Curative Resection of Hepatitis C Virus‐related Hepatocellular Carcinoma

1996 • 20 citations

N -Acetyltransferase 2 Polymorphism Is Not Related to the Risk of Advanced Alcoholic Liver Disease

2002 • 15 citations

Alcoholic liver disease in Japanese patients: A comparison with Caucasians

1991 • 13 citations

Clinical Characteristics of Patients in Their 40s With HCV Antibody‐Positive Hepatocellular Carcinoma

2000 • 12 citations

The effect of ethanol intake on the development of hepatocellular carcinoma in HBsAg carriers.

1994 • 11 citations