Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1

Present Knowledge in Nutrition.

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Hepatic Vitamin A Depletion in Alcoholic Liver Injury

1982 • 343 citations

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

1989 • 320 citations

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1998 • 319 citations

Ethanol-, fasting-, and aceton-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies

1988 • 316 citations

Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.

1999 • 234 citations

Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease

1993 • 232 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

1993 • 216 citations

Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome

1996 • 189 citations

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

1989 • 181 citations

Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation

1996 • 177 citations

Catalytic Efficiency of Human Alcohol Dehydrogenases for Retinol Oxidation and Retinal Reduction

1994 • 172 citations

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

1988 • 170 citations

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors

1995 • 164 citations

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

1992 • 161 citations

Retinoic acid metabolism by a system reconstituted with cytochrome P-450

1984 • 154 citations

Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver

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1979 • 129 citations

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1991 • 129 citations

Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver

1979 • 126 citations

Respective Roles of Human Cytochrome P‐4502E1, 1A2, and 3A4 in the Hepatic Microsomal Ethanol Oxidizing System

1998 • 125 citations

Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract

1990 • 118 citations

Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats

1991 • 118 citations

The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina

1971 • 113 citations

Alcohol and Cancer

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Regulation of Metabolism by Retinoic Acid and its Nuclear Receptors

1996 • 106 citations

β-Oxidation in Rabbit Liver in Vitro and in the Perfused Ferret Liver Contributes to Retinoic Acid Biosynthesis from β-Apocarotenoic Acids

1996 • 105 citations

Cellular Retinol-binding Protein-supported Retinoic Acid Synthesis

1996 • 103 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA,

1993 • 94 citations

Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans

1997 • 94 citations

Contribution to first‐pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family

1998 • 94 citations

Vitamin A and zinc metabolism in alcoholism

1980 • 93 citations

Hydroxyl-radical production and ethanol oxidation by liver microsomes isolated from ethanol-treated rats

1986 • 88 citations

Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver

1994 • 85 citations

Increased metabolism of retinoic acid after chronic ethanol consumption in rat liver microsomes

1982 • 84 citations

Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.

1992 • 82 citations

Participation of P450 3A Enzymes in Rat Hepatic Microsomal Retinoic Acid 4-Hydroxylation

1993 • 72 citations

Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver.

1994 • 68 citations

Increased Vitamin A in Esophagus and Other Extrahepatic Tissues after Chronic Ethanol Consumption in the Rat

1986 • 64 citations

Chronic Alcohol Intake Interferes with Retinoid Metabolism and Signaling

2009 • 57 citations

DNA cleavage during ethanol metabolism: Role of superoxide radicals and catalytic iron

1990 • 50 citations

Age-Related Effects of Chronic Ethanol Intake on Vitamin A Status in Fisher 344 Rats

1991 • 41 citations

Free Radical Formation in Livers of Rats Treated Acutely and Chronically with Alcohol

1997 • 39 citations

Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid

1994 • 36 citations

Retinoic Acid Regulates Retinol Metabolism via Feedback Inhibition of Retinol Oxidation and Stimulation of Retinol Esterification in Ferret Liver

1993 • 35 citations

Effect of ethanol on nitrosamine metabolism and distribution

1987 • 35 citations

CYP2C7 expression in rat liver and hepatocytes: regulation by retinoids

1997 • 32 citations

IDentification of a microsomal retinoic acid synthase as a microsomal cytochrome P-450-linked monooxygenase system

1993 • 24 citations

Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes.

1993 • 22 citations

Retinoids in cancer prevention

1993 • 21 citations