The Multiple cpb Cysteine Proteinase Genes ofLeishmania mexicana Encode Isoenzymes That Differ in Their Stage Regulation and Substrate Preferences

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1995 • 387 citations

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1993 • 383 citations

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

1996 • 379 citations

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1992 • 372 citations

Coupling of poly(A) site selection and trans-splicing in Leishmania.

1993 • 345 citations

Structure and expression of two genes that encode distinct drought-inducible cysteine proteinases in Arabidopsis thaliana

1993 • 298 citations

The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.

1992 • 294 citations

The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease

1995 • 264 citations

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

1996 • 221 citations

Molecular cloning and gibberellin-induced expression of multiple cysteine proteinases of rice seeds (oryzains).

1991 • 215 citations

A shuttle vector which facilitates the expression of transfected genes inTrypanosoma cruzi and Leishmania

1992 • 214 citations

Potency and Selectivity of the Cathepsin L Propeptide as an Inhibitor of Cysteine Proteases

1996 • 193 citations

Axenic cultivation and characterization ofLeishmania mexicanaamastigote-like forms

1992 • 187 citations

Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes.

1994 • 173 citations

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes

1992 • 166 citations

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1994 • 139 citations

Expression of the Collagenolytic and Ras-Induced Cysteine Proteinase Cathepsin L and Proliferation-Associated Oncogenes in Synovial Cells of MRL/I Mice and Patients with Rheumatoid Arthritis

1990 • 134 citations

A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C‐terminal extension

1989 • 131 citations

Participation of cathepsin L on bone resorption

1993 • 130 citations

Three distinct RNAs for the surface protease gp63 are differentially expressed during development of Leishmania donovani chagasi promastigotes to an infectious form.

1992 • 129 citations

Characterization of a multi‐copy gene for a major stage‐specific cysteine proteinase of Leishmania mexicana

1992 • 106 citations

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1986 • 105 citations

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Leishmania major:Comparison of the Cathepsin L- and B-like Cysteine Protease Genes with Those of Other Trypanosomatids

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Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction

1993 • 76 citations

A developmentally regulated cysteine proteinase gene of Leishmania mexicana

1992 • 74 citations

Amino acid and carbohydrate composition of a lysosomal cysteine proteinase from Trypanosoma cruzi. Absence of phosphorylated mannose residues

1990 • 71 citations

The C-terminal extension of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi

1991 • 70 citations

Intergenic Regions between Tandem gp63 Genes Influence the Differential Expression of gp63 RNAs in Leishmania chagasi Promastigotes

1995 • 70 citations

A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle.

1993 • 65 citations

Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana

1990 • 65 citations

Stage-regulated expression of cruzipain, the major cysteine protease of Trypanosoma cruzi is independent of the level of RNA

1996 • 65 citations

Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana

1994 • 63 citations

Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.

1994 • 61 citations

Trypanosomiasis and leishmaniasis: Biology and control

1997 • 59 citations

Developmentally Regulated Expression of a Novel 59-kDa Product of the Major Surface Protease (Msp or gp63) Gene Family of Leishmania Chagasi

1995 • 49 citations

Distribution of parasite cysteine proteinases in lesions of mice infected with Leishmania mexicana amastigotes

1994 • 40 citations

Parasite cysteine proteinases

1996 • 38 citations

Stage-specific proteinases ofLeishmania mexicana mexicanapromastigotes

1992 • 36 citations

Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array

1994 • 34 citations

Expression and deletion analysis of the Trypanosoma brucei rhodesiense cysteine protease in Escherichia coli

1991 • 30 citations

On the post-translational modificationa at the C-terminal domain of the major cysteine proteinase (cruzipain) fromTrypanosoma cruzi

1992 • 26 citations

Cloning and sequencing of the cysteine protease cDNA fromTrypanosoma brucei rhodesiense

1990 • 25 citations

Expression of Cysteine Proteinases by Metacyclic Promastigotes of Leishmania mexicana

1994 • 23 citations

Cysteine proteases of parasites: A remarkable diversity of function

1995 • 17 citations