Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

1979 • 1,595 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Isolation of a human prostate carcinoma cell line (DU 145)

1978 • 1,176 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Cancer statistics, 1990

1990 • 818 citations

Mendelian inheritance of familial prostate cancer.

1992 • 803 citations

Tumor suppressor genes

1991 • 775 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

The prostate: An increasing medical problem

1990 • 356 citations

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

1990 • 342 citations

Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder.

1990 • 252 citations

Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.

1989 • 237 citations

ras gene mutations in human prostate cancer.

1990 • 202 citations

Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.

1991 • 194 citations

Genetic Alterations During Colorectal-Tumor Development

1989 • 187 citations

Frequency and pattern of karyotypic abnormalities in human prostate cancer.

1990 • 172 citations

Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.

1992 • 162 citations

Regulation of prostate growth

1991 • 159 citations

Mutations in Human Breast Cancer: An Overview

1989 • 155 citations

Chromosome study of five cancers of the prostate

1985 • 152 citations

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

1991 • 150 citations

Epidemiologic evidence regarding predisposing factors to prostate cancer

1990 • 149 citations

Growth factors and oncogenes in prostate cancer.

1990 • 115 citations

Alterations of The P53 Gene Are Associated With The Progression Of A Human Prostate Carcinoma

1992 • 107 citations

Wild type human p53 is antiproliferative in SV40-transformed hamster cells.

1990 • 97 citations

P53 and Ki‐67 Immunoreactivity in Human Prostate Cancer and Benign Hyperplasia

1992 • 61 citations

Use of labeled primers in polymerase chain reaction (LP-PCR) for a rapid detection of the product

1989 • 57 citations

Tumor suppressor genes: Possible functions in the negative regulation of cell proliferation

1990 • 47 citations

Recessive Genetic Mechanisms in the Oncogenesis of Prostatic Carcinoma

1991 • 10 citations

A Pulmonary Large Cell Carcinoma Cell Line Expressing Neuroendocrine Cell Markers and Human Chorionic Gonadotropin α‐Subunit

1991 • 7 citations

[International comparison of prostatic cancer].

1989 • 2 citations