Adenovirus-mediated over-expression of Interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.

1986 • 496 citations

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

1995 • 477 citations

Neurotoxicity ofN-methyl-d-aspartate is markedly enhanced in developing rat central nervous system

1988 • 465 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 • 450 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.

1992 • 319 citations

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

1992 • 302 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

1995 • 282 citations

Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 • 245 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain

1995 • 217 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

The Interleukin-1 Receptor Antagonist (rhIL-1ra) Protects against Cerebral Infarction in a Rat Model of Hypoxia-Ischemia

1994 • 161 citations

Convulsants induce interleukin-1β messenger RNA in rat brain

1990 • 158 citations

Interleukins and Tumor Necrosis Factor in Inflammation

1990 • 129 citations

Quantitative assessment of neuroprotection against NMDA-induced brain injury

1989 • 102 citations

Central endotoxin induces different patterns of interleukin (IL)-1 beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery.

1995 • 94 citations

Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector

1995 • 93 citations

Endotoxin-stimulated production of rat hypothalamic interleukin-1β in vivo and in vitro, measured by specific immunoradiometric assay

1993 • 86 citations

Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats

1995 • 78 citations

Adenovirus vectors enter the brain

1993 • 60 citations

Interleukin-1 Receptor Antagonist

2006 • 57 citations

The severity of excitotoxic brain injury is dependent on brain temperature in immature rat

1991 • 51 citations

Central endotoxin induces different patterns of interleukin (IL)-1 beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery

1995 • 51 citations

Blocking of Interleukin-1 Activity is a Beneficial Approach to Ischemia Brain Edema Formation

1994 • 26 citations

Interleukin-1β Induces Cytosolic Phospholipase A2 Gene in Rat C6 Glioma Cell Line

1994 • 18 citations

Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.

1990 • 14 citations