Recommendations for Advancing Development of Acute Stroke Therapies

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

2001 • 5,358 citations

Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest

2002 • 5,064 citations

Intra-arterial Prourokinase for Acute Ischemic Stroke

1999 • 3,037 citations

The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials

2001 • 2,522 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke

1997 • 1,840 citations

Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug Development

1999 • 1,203 citations

Group Sequential Methods with Applications to Clinical Trials

1999 • 1,177 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Clinical Trials : A Methodologic Perspective

1997 • 807 citations

Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging

2000 • 683 citations

Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke

2000 • 665 citations

The ischemic penumbra

1999 • 648 citations

Combined Intravenous and Intra-Arterial r-TPA Versus Intra-Arterial Therapy of Acute Ischemic Stroke

1999 • 638 citations

Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imaging

1997 • 578 citations

Magnetic Resonance Imaging of Acute Stroke

1998 • 550 citations

Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients

2002 • 534 citations

Public Perception of Stroke Warning Signs and Knowledge of Potential Risk Factors

1998 • 515 citations

Combating Hyperthermia in Acute Stroke

1998 • 489 citations

Outcome Measures in Acute Stroke Trials

2000 • 482 citations

Progressive Derangement of Periinfarct Viable Tissue in Ischemic Stroke

1992 • 423 citations

Identifying Stroke in the Field

2000 • 408 citations

Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

2000 • 337 citations

Stroke Patients’ Knowledge of Stroke

1997 • 323 citations

Prolonged Persistence of Substantial Volumes of Potentially Viable Brain Tissue After Stroke

1996 • 318 citations

Prehospital and Emergency Department Delays After Acute Stroke

2000 • 315 citations

Quantitative Assessment of the Ischemic Brain by Means of Perfusion-Related Parameters Derived From Perfusion CT

2001 • 269 citations

Abciximab in Acute Ischemic Stroke

2000 • 265 citations

Trends in Acute Ischemic Stroke Trials Through the 20th Century

2001 • 258 citations

Improving Delivery of Acute Stroke Therapy

2002 • 252 citations

Effects of public and professional education on reducing the delay in presentation and referral of stroke patients.

1992 • 249 citations

Recommendations for Clinical Trial Evaluation of Acute Stroke Therapies

2001 • 234 citations

Randomized Controlled Trial of a Comprehensive Stroke Education Program for Patients and Caregivers

1999 • 228 citations

Effect of citicoline on ischemic lesions as measured by diffusion‐weighted magnetic resonance imaging

2000 • 215 citations

Ischemic Core and Penumbra in Human Stroke

1999 • 205 citations

Group Sequential Methods

1999 • 196 citations

Early Stroke Recognition: Developing an Out‐of‐hospital NIH Stroke Scale

1997 • 182 citations

Duration of Glutamate Release After Acute Ischemic Stroke

1997 • 179 citations

Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging

2000 • 175 citations

Applications of diffusion–perfusion magnetic resonance imaging in acute ischemic stroke

1999 • 157 citations

Delayed Hospital Arrival for Acute Stroke: The Minnesota Stroke Survey

1998 • 154 citations

Factors determining the therapeutic window for stroke

1998 • 145 citations

Which Targets Are Relevant for Therapy of Acute Ischemic Stroke?

1999 • 138 citations

The 2 × 2 factorial design: Its application to a randomized trial of aspirin and U.S. physicians

1985 • 120 citations

An Overview of Acute Stroke Therapy

2000 • 112 citations

Time to Treatment Influences the Impact of ST-Segment Resolution on One-Year Prognosis

2001 • 107 citations

Community Education for Stroke Awareness

1999 • 102 citations

Microplasmin: A Novel Thrombolytic That Improves Behavioral Outcome After Embolic Strokes in Rabbits

2002 • 102 citations

HU-211, a Novel Noncompetitive N -Methyl- <scp>d-</scp> Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat

1995 • 97 citations

Multiparametric MRI Tissue Characterization in Clinical Stroke With Correlation to Clinical Outcome

2001 • 96 citations

Further Evolution Toward Effective Therapy for Acute Ischemic Stroke

1998 • 91 citations

The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator–treated stroke (CLASS-T)

2001 • 86 citations

Heterogeneity of Stroke Pathophysiology and Neuroprotective Clinical Trial Design

2002 • 82 citations

Combination Therapy Stroke Trial: Recombinant Tissue-Type Plasminogen Activator with/without Lubeluzole

2001 • 69 citations

Thrombolytic stroke therapy

1999 • 68 citations

Neuroprotective FK506 Does Not Alter In Vivo Nitric Oxide Production During Ischemia and Early Reperfusion in Rats

1999 • 60 citations

Neuroprotection as Initial Therapy in Acute Stroke

1998 • 59 citations

Comparison of TNK With Wild-Type Tissue Plasminogen Activator in a Rabbit Embolic Stroke Model

2001 • 50 citations

Have Randomized Controlled Trials of Neuroprotective Drugs Been Underpowered?

2001 • 50 citations

Metal ion chelation in neurodegenerative disorders

2002 • 42 citations

Usefulness of postischemic thrombolysis with or without neuroprotection in a focal embolic model of cerebral ischemia

2000 • 42 citations

Cerebrovascular Diseases: Nineteenth Princeton Stroke Conference

1995 • 33 citations

Advances in neuroimaging of acute stroke

2000 • 33 citations

The therapeutic window in ischemic brain injury

1995 • 30 citations

Neuroprotection of Acute Ischemic Stroke: Where are We?

1999 • 25 citations

Pharmacological approach to functional reorganization: the role of norepinephrine.

1999 • 23 citations

The Concept of the Therapeutic Window: A Synthesis of Critical Issues**Our studies are supported by USPHS Grant NS05820. Ms. Helen Valkowitz helped to prepare the typescript.

1995 • 22 citations

Effect of Abciximab on Prothrombin Activation and Thrombin Generation in Acute Coronary Syndromes Without ST-Segment Elevation

2002 • 19 citations

Stroke-related knowledge among patients with access to medical care in the stroke belt

1999 • 15 citations

Mechanical thrombolysis in acute stroke

2003 • 14 citations

Echoplanar magnetic resonance imaging in acute stroke

2000 • 14 citations

Stroke Therapy Academic Industry Roundtable. Recommendations for clinical trial evaluation of acute stroke therapies.

2001 • 10 citations

Recruitment of the Ischemic Penumbra into the Necrotic Core

1997 • 9 citations

What Questions Can Large, Simple Trials Answer?

1998 • 8 citations

Reliable computer assisted measurement of stroke lesion volumes

2002 • 7 citations

The new magnetic resonance techniques of diffusion and perfusion imaging.

1997 • 3 citations

Outcomes of ancrod in acute ischemic stroke

2000 • 3 citations