Antagonistic Effects of an Alternative Splice Variant of Human IL-4, IL-4δ2, on IL-4 Activities in Human Monocytes and B Cells

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

1997 • 743 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

1984 • 392 citations

Defining protective responses to pathogens: cytokine profiles in leprosy lesions

1991 • 375 citations

Functions of IL-4 and Control of Its Expression

2017 • 337 citations

Functions of IL-4 and Control of Its Expression

1997 • 290 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.

1992 • 176 citations

Three-Dimensional Solution Structure of Human Interleukin-4 by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy

1992 • 165 citations

Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils

1997 • 156 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gamma.

1988 • 139 citations

Crystal structure of recombinant human interleukin-4.

1992 • 132 citations

Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils

1997 • 131 citations

An alternative splice variant of human IL-4, IL-4 delta 2, inhibits IL-4-stimulated T cell proliferation.

1996 • 128 citations

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1990 • 119 citations

Crystal structure of human recombinant interleukin‐4 at 2.25 Å resolution

1992 • 118 citations

Crystal structure of recombinant human interleukin-4.

1992 • 113 citations

Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4

1995 • 105 citations

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients

1996 • 102 citations

Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.

1996 • 78 citations

IL-10 inhibits prostaglandin E₂ production by lipopolysaccharide-stimulated monocytes

1994 • 77 citations

High affinity binding of human interleukin 4 to cell lines

1987 • 70 citations

The IL-4 receptor alpha-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression.

1997 • 69 citations

Use of avidin-biotin complex in an ELISA system: a quantitative comparison with two other immunoperoxidase detection systems using keratin antisera.

1983 • 65 citations

A recombinant extracellular domain of the human interleukin 4 receptor inhibits the biological effects of interleukin 4 on T and B lymphocytes

1991 • 63 citations

Generation of a variant of human interleukin-4 by alternative splicing

1996 • 61 citations

Activation of STAT5 by Lipopolysaccharide Through Granulocyte-Macrophage Colony-Stimulating Factor Production in Human Monocytes

1998 • 57 citations

Site‐directed mutagenesis reveals the importance of disulfide bridges and aromatic residues for structure and proliferative activity of human Interleukin‐4

1991 • 57 citations

Identification and Characterization of Two Alternative Splice Variants of Human Interleukin-2

1996 • 51 citations

Homodimerization of the human interleukin 4 receptor α chain induces Cɛ germline transcripts in B cells in the absence of the interleukin 2 receptor γ chain

1997 • 49 citations

An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4

1997 • 48 citations

Impaired Balance of Interleukin‐4 and Interferon‐y Production in Infections with Schistosoma mansoni and Intestinal Nematodes

1991 • 44 citations

Disulfide assignments in recombinant mouse and human interleukin 4

1991 • 42 citations

Identification of an alternatively spliced transcript of human interleukin-4 lacking the sequence encoded by exon 2.

1993 • 36 citations

Experimental and theoretical studies of the three‐dimensional structure of human interleukin‐4

1991 • 36 citations

Alternative splice variants of cytokines: Making a list

1997 • 34 citations

IL-4: Structure and Function

1992 • 33 citations