Use of Antisense Oligodeoxynucleotides to Study the Physiological Functions of Neuropeptide Y

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides

1993 • 528 citations

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

1988 • 510 citations

Anatomy and physiology of the neuroendocrine arcuate nucleus

1985 • 306 citations

Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action

1985 • 281 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

Life without neuropeptide Y.

1998 • 244 citations

Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology.

1992 • 231 citations

Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists

1997 • 210 citations

Nutritional Infertility: The Role of the Interconnected Hypothalamic Neuropeptide Y–Galanin–Opioid Network

1996 • 207 citations

Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue.

1987 • 203 citations

Neuropeptide Y feeding receptors: are multiple subtypes involved?

1999 • 200 citations

Increased Neuropeptide Y Concentrations in Specific Hypothalamic Regions of Streptozocin-Induced Diabetic Rats

1989 • 186 citations

Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.

1993 • 185 citations

Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding

1995 • 182 citations

Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion

1994 • 180 citations

Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides

1997 • 176 citations

Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat.

1993 • 174 citations

Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior

1988 • 172 citations

Neuropeptide-Y Concentration in Microdissected Hypothalamic Regions andin VitroRelease from the Medial Basal Hypothalamus-Preoptic Area of Streptozotocin-Diabetic Rats with and without Insulin Substitution Therapy*

1990 • 128 citations

Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokinin

1988 • 106 citations

Neuropeptide Y is a neuromodulator of pulsatile luteinizing hormone-releasing hormone release in the gonadectomized rhesus monkey.

1992 • 94 citations

Morphological evidence for neuronal regulation of luteinizing hormone-releasing hormone-containing neurons by neuropeptide Y in the rat septo-preoptic area

1990 • 92 citations

Short-term behavioral effects of posterior pituitary peptides in mice

1981 • 78 citations

Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats

1996 • 77 citations

Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain

1997 • 72 citations

ICV administration of anti-NPY antisense oligonucleotide: effects on feeding behavior, body weight, peptide content and peptide release

1995 • 66 citations

Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen

1992 • 64 citations

Expression of Neuropeptide Y Precursor-Immunoreactivity in the Hypothalamic Dopaminergic Tubero-Infundibular System during Lactation in Rodents*

1991 • 63 citations

Central administration of antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release

1995 • 63 citations

Hypothalamic neuropeptide-Y gene expression increases before the onset of the ovarian steroid-induced luteinizing hormone surge.

1994 • 63 citations

Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y

1998 • 61 citations

Dynamic Changes in Neuropeptide Y Concentrations in the Median Eminence in Association with Preovulatory Luteinizing Hormone Release in the Rat

1989 • 57 citations

Evidence that Hypothalamic Neuropeptide Y Gene Expression Increases Before the Onset of the Preovulatory LH Surge*

1995 • 51 citations

An interactive physiological role of neuropeptide Y and galanin in pulsatile pituitary luteinizing hormone secretion.

1996 • 43 citations

Human neuropeptide Y Y1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction

1993 • 27 citations

Disinhibition from opioid influence augments hypothalamic neuropeptide Y (NPY) gene expression and pituitary luteinizing hormone release: effects of NPY messenger ribonucleic acid antisense oligodeoxynucleotides.

1996 • 27 citations

Neuropeptide Y Y1 receptor antisense oligodeoxynucleotides enhance food intake in energy-deprived rats

1998 • 25 citations

Simultaneous Induction of Neuropeptide Y and Gonadotropin-Releasing Hormone Release in the Rabbit Hypothalamus

1989 • 22 citations

The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus

1998 • 20 citations

Antisense Oligonucleotides: New Tools for the Study of Brain Function

1996 • 16 citations